The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cadherins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 168: Cadherin-related family member 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q8IGX4 (/IDA) Q9VVG0 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
2 Q9VFH5 (/ISM) Q9VGG5 (/ISM)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 Q8IGX4 (/IPI) Q9VVG0 (/IPI)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q9BYE9 (/IPI)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 Q9BYE9 (/IDA)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 E9Q7P9 (/ISO)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 E9Q7P9 (/ISS)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
4 Q8IGX4 (/ISS) Q9VFH5 (/ISS) Q9VGG5 (/ISS) Q9VVG0 (/ISS)
Cell-cell adhesion mediated by cadherin GO:0044331
The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.
3 Q8IGX4 (/IDA) Q9BYE9 (/IDA) Q9VVG0 (/IDA)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
2 Q8IGX4 (/IDA) Q9VVG0 (/IDA)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
2 Q8IGX4 (/IDA) Q9VVG0 (/IDA)
Cell-cell adhesion mediated by cadherin GO:0044331
The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.
2 Q9VFH5 (/ISM) Q9VGG5 (/ISM)
Dorsal appendage formation GO:0046843
Establishment of the dorsal filaments, elaborate specializations of the chorion that protrude from the anterior end of the egg and facilitate embryonic respiration.
2 Q8IGX4 (/IDA) Q9VVG0 (/IDA)
Open tracheal system development GO:0007424
The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster.
1 Q9VFH5 (/IGI)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
1 Q9BYE9 (/IDA)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
1 E9Q7P9 (/ISO)
Epithelial cell differentiation GO:0030855
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.
1 E9Q7P9 (/ISS)
Regulation of microvillus length GO:0032532
A process that modulates the length of a microvillus.
1 Q9BYE9 (/IMP)
Regulation of microvillus length GO:0032532
A process that modulates the length of a microvillus.
1 E9Q7P9 (/ISO)
Regulation of microvillus length GO:0032532
A process that modulates the length of a microvillus.
1 E9Q7P9 (/ISS)
Cell-cell adhesion mediated by cadherin GO:0044331
The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.
1 E9Q7P9 (/ISO)
Cell-cell adhesion mediated by cadherin GO:0044331
The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains.
1 E9Q7P9 (/ISS)
Negative regulation of cell growth involved in contact inhibition GO:0060243
The negative regulation of cell growth in response to increased cell density.
1 Q9BYE9 (/IDA)
Negative regulation of cell growth involved in contact inhibition GO:0060243
The negative regulation of cell growth in response to increased cell density.
1 E9Q7P9 (/ISO)
Negative regulation of cell growth involved in contact inhibition GO:0060243
The negative regulation of cell growth in response to increased cell density.
1 E9Q7P9 (/ISS)
Intermicrovillar adhesion GO:0090675
The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin.
1 Q9BYE9 (/IMP)
Intermicrovillar adhesion GO:0090675
The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin.
1 E9Q7P9 (/ISO)
Intermicrovillar adhesion GO:0090675
The biological adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin.
1 E9Q7P9 (/ISS)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 Q8IGX4 (/ISS) Q9VFH5 (/ISS) Q9VGG5 (/ISS) Q9VVG0 (/ISS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
3 Q8IGX4 (/IDA) Q9BYE9 (/IDA) Q9VVG0 (/IDA)
Microvillus GO:0005902
Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells.
2 Q8IGX4 (/IDA) Q9VVG0 (/IDA)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
1 Q9BYE9 (/IDA)
Brush border GO:0005903
The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell.
1 E9Q7P9 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 E9Q7P9 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
1 E9Q7P9 (/ISS)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 Q9BYE9 (/IDA)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 E9Q7P9 (/ISO)
Brush border membrane GO:0031526
The portion of the plasma membrane surrounding the brush border.
1 E9Q7P9 (/ISS)
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
1 Q9BYE9 (/IDA)
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
1 E9Q7P9 (/ISO)
Microvillus membrane GO:0031528
The portion of the plasma membrane surrounding a microvillus.
1 E9Q7P9 (/ISS)
Spanning component of plasma membrane GO:0044214
The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.
1 Q9BYE9 (/IDA)
Spanning component of plasma membrane GO:0044214
The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.
1 E9Q7P9 (/ISO)
Spanning component of plasma membrane GO:0044214
The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.
1 E9Q7P9 (/ISS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9BYE9 (/HDA)