The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cadherins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Protocadherin alpha 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
22 A0A0A6YW27 (/IPI) A0A2R8RMH2 (/IPI) A9CPE6 (/IPI) F1QGL4 (/IPI) F8W3H1 (/IPI) O14917 (/IPI) O88689 (/IPI) Q6NXW8 (/IPI) Q7TQF1 (/IPI) Q80TE2 (/IPI)
(12 more)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
10 A0A140LG84 (/IDA) A0A2R8QME5 (/IDA) A1L1W7 (/IDA) C4P340 (/IDA) C4P341 (/IDA) F8W3X3 (/IDA) O88689 (/IDA) Q91XZ2 (/IDA) Q91XZ4 (/IDA) Q91Y13 (/IDA)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
10 Q5DRC6 (/ISS) Q5DRC8 (/ISS) Q5DRE5 (/ISS) Q5DRE8 (/ISS) Q767I8 (/ISS) Q767I8 (/ISS) Q9UN66 (/ISS) Q9UN72 (/ISS) Q9UN74 (/ISS) Q9Y5E3 (/ISS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
10 Q5DRC6 (/ISS) Q5DRC8 (/ISS) Q5DRE5 (/ISS) Q5DRE8 (/ISS) Q767I8 (/ISS) Q767I8 (/ISS) Q9UN66 (/ISS) Q9UN72 (/ISS) Q9UN74 (/ISS) Q9Y5E3 (/ISS)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
6 A0A140LG84 (/IDA) A0A2R8QME5 (/IDA) A1L1W7 (/IDA) C4P340 (/IDA) C4P341 (/IDA) F8W3X3 (/IDA)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 O88689 (/IDA) Q91XZ2 (/IDA) Q91XZ4 (/IDA) Q91Y13 (/IDA)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
1 Q9Y5G4 (/HDA)
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
1 O93509 (/IPI)
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
1 Q8VHR0 (/NAS)

There are 54 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
21 Q6ZQD4 (/TAS) Q91Y16 (/TAS) Q9UN71 (/TAS) Q9UN72 (/TAS) Q9UN73 (/TAS) Q9UN74 (/TAS) Q9Y5E3 (/TAS) Q9Y5E5 (/TAS) Q9Y5E6 (/TAS) Q9Y5E7 (/TAS)
(11 more)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
18 Q9UN72 (/TAS) Q9UN73 (/TAS) Q9UN74 (/TAS) Q9Y5E3 (/TAS) Q9Y5E5 (/TAS) Q9Y5E6 (/TAS) Q9Y5E7 (/TAS) Q9Y5E8 (/TAS) Q9Y5F1 (/TAS) Q9Y5F2 (/TAS)
(8 more)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
14 Q91Y03 (/NAS) Q9NRJ7 (/NAS) Q9UN67 (/NAS) Q9UN70 (/NAS) Q9UN71 (/NAS) Q9Y5E1 (/NAS) Q9Y5E3 (/NAS) Q9Y5E4 (/NAS) Q9Y5E5 (/NAS) Q9Y5E6 (/NAS)
(4 more)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
12 Q91Y03 (/TAS) Q9NRJ7 (/TAS) Q9UN67 (/TAS) Q9Y5E1 (/TAS) Q9Y5E3 (/TAS) Q9Y5E4 (/TAS) Q9Y5E5 (/TAS) Q9Y5E6 (/TAS) Q9Y5E7 (/TAS) Q9Y5E9 (/TAS)
(2 more)
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
12 Q91Y03 (/TAS) Q9NRJ7 (/TAS) Q9UN67 (/TAS) Q9Y5E1 (/TAS) Q9Y5E3 (/TAS) Q9Y5E4 (/TAS) Q9Y5E5 (/TAS) Q9Y5E6 (/TAS) Q9Y5E7 (/TAS) Q9Y5E9 (/TAS)
(2 more)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
8 E9PX28 (/IDA) E9PXQ7 (/IDA) Q6P0A6 (/IDA) Q80TE2 (/IDA) Q91XZ4 (/IDA) Q91Y13 (/IDA) Q925I8 (/IDA) Q9Z1B1 (/IDA)
Neural tube formation GO:0001841
The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system.
6 A0A140LG84 (/IMP) A0A2R8QME5 (/IMP) A1L1W7 (/IMP) C4P340 (/IMP) C4P341 (/IMP) F8W3X3 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
6 E9PX28 (/IDA) E9PXQ7 (/IDA) Q6P0A6 (/IDA) Q80TE2 (/IDA) Q925I8 (/IDA) Q9Z1B1 (/IDA)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
6 A0A140LG84 (/IMP) A0A2R8QME5 (/IMP) A1L1W7 (/IMP) C4P340 (/IMP) C4P341 (/IMP) F8W3X3 (/IMP)
Brain morphogenesis GO:0048854
The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
6 A0A140LG84 (/IMP) A0A2R8QME5 (/IMP) A1L1W7 (/IMP) C4P340 (/IMP) C4P341 (/IMP) F8W3X3 (/IMP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
5 I6LBW8 (/NAS) I6LBX8 (/NAS) Q767I2 (/NAS) Q767I4 (/NAS) Q767I9 (/NAS)
Somitogenesis GO:0001756
The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo.
4 A0A0B5JW50 (/IMP) Q6IS19 (/IMP) Q7TSK3 (/IMP) Q805F0 (/IMP)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
4 Q5DRC8 (/ISS) Q5DRE5 (/ISS) Q9UN72 (/ISS) Q9Y5E3 (/ISS)
Cell-cell recognition GO:0009988
Cell recognition between cells. May involve the formation of specialized cell junctions.
4 Q5DRC8 (/ISS) Q5DRE5 (/ISS) Q9UN72 (/ISS) Q9Y5E3 (/ISS)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
4 A0A0B5JFG8 (/IMP) A0A2R8Q566 (/IMP) A9QUV5 (/IMP) F1QRP2 (/IMP)
Cell migration involved in gastrulation GO:0042074
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).
4 A0A0B5JFG8 (/IMP) A0A2R8Q566 (/IMP) A9QUV5 (/IMP) F1QRP2 (/IMP)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
4 A0A2R8RMH2 (/IMP) A9CPE6 (/IMP) F1QGL4 (/IMP) F8W3H1 (/IMP)
Epiboly involved in gastrulation with mouth forming second GO:0055113
The expansion of one cell sheet over other cells involved in deuterostomic gastrulation.
4 A0A0B5JFG8 (/IMP) A0A2R8Q566 (/IMP) A9QUV5 (/IMP) F1QRP2 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
3 A7MB46 (/ISS) Q9HCL0 (/ISS) Q9HCL0 (/ISS)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
3 Q6NXW8 (/ISS) Q91XY7 (/ISS) Q9Z1B0 (/ISS)
Thalamus development GO:0021794
The process in which the thalamus changes over time, from its initial formation to its mature state.
3 A0A0B5JW50 (/IMP) Q6IS19 (/IMP) Q805F0 (/IMP)
Adult behavior GO:0030534
Behavior in a fully developed and mature organism.
3 E9PXF0 (/IMP) Q3UTP0 (/IMP) Q5HZI5 (/IMP)
Odontogenesis GO:0042476
The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food.
3 I6LBW4 (/NAS) Q767I8 (/NAS) Q767I8 (/NAS)
Paraxial mesoderm development GO:0048339
The process whose specific outcome is the progression of the paraxial mesoderm over time, from its formation to the mature structure. The paraxial mesoderm is the mesoderm located bilaterally adjacent to the notochord and neural tube.
3 A0A0B5JW50 (/IMP) Q6IS19 (/IMP) Q805F0 (/IMP)
Negative regulation of synaptic transmission GO:0050805
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse.
3 E9PXF0 (/IMP) Q3UTP0 (/IMP) Q5HZI5 (/IMP)
Synaptic membrane adhesion GO:0099560
The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
3 E9PXF0 (/IDA) Q3UTP0 (/IDA) Q5HZI5 (/IDA)
Synaptic membrane adhesion GO:0099560
The attachment of presynaptic membrane to postsynaptic membrane via adhesion molecules that are at least partially embedded in the plasma membrane.
3 E9PXF0 (/IMP) Q3UTP0 (/IMP) Q5HZI5 (/IMP)
Presynaptic active zone assembly GO:1904071
The aggregation, arrangement and bonding together of a set of components to form a presynaptic active zone. The presynaptic active zone is a specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix.
3 E9PXF0 (/IMP) Q3UTP0 (/IMP) Q5HZI5 (/IMP)
Regulation of synaptic vesicle clustering GO:2000807
Any process that modulates the frequency, rate or extent of synaptic vesicle clustering.
3 E9PXF0 (/IMP) Q3UTP0 (/IMP) Q5HZI5 (/IMP)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
2 O88689 (/IC) Q91XZ2 (/IC)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
2 F1LRA0 (/IEP) I6LBX6 (/IEP)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
2 A0A0B5JFA0 (/IMP) C4P342 (/IMP)
Cell-cell recognition GO:0009988
Cell recognition between cells. May involve the formation of specialized cell junctions.
2 Q91XZ4 (/IDA) Q91Y13 (/IDA)
Axon extension GO:0048675
Long distance growth of a single axon process involved in cellular development.
2 A0A0B5JFA0 (/IMP) C4P342 (/IMP)
Retina development in camera-type eye GO:0060041
The process whose specific outcome is the progression of the retina over time, from its formation to the mature structure. The retina is the innermost layer or coating at the back of the eyeball, which is sensitive to light and in which the optic nerve terminates.
2 A0A0B5JFA0 (/IMP) C4P342 (/IMP)
Camera-type eye photoreceptor cell differentiation GO:0060219
The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell in a camera-type eye.
2 A0A0B5JFA0 (/IMP) C4P342 (/IMP)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
1 Q8VHR0 (/NAS)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
1 Q91XX1 (/TAS)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
1 O95206 (/TAS)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 D3ZE55 (/IDA)
Chemical synaptic transmission GO:0007268
The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
1 Q7TSK3 (/ISO)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 Q8VHR0 (/IEP)
Long-term memory GO:0007616
The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation.
1 D3ZE55 (/TAS)
Endosome to lysosome transport GO:0008333
The directed movement of substances from endosomes to lysosomes.
1 Q91XY5 (/IMP)
Morphogenesis of embryonic epithelium GO:0016331
The process in which the anatomical structures of embryonic epithelia are generated and organized.
1 Q7TSK3 (/IMP)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
1 Q8VHR0 (/ISO)
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339
The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction.
1 Q91XX1 (/TAS)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 D3ZE55 (/EXP)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
1 Q7TSK3 (/ISO)
Synapse organization GO:0050808
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell).
1 Q91XX1 (/IGI)
Lipid tube assembly involved in organelle fusion GO:0060989
The aggregation, arrangement and bonding together of a set of macromolecules to form a macromolecular complex that contains a tube of lipid surrounded by a protein coat involved in membrane shaping of vesicle membranes as organelles fuse.
1 Q91XY5 (/IMP)
Regulation of synaptic membrane adhesion GO:0099179
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
1 D3ZE55 (/IDA)
Regulation of synaptic membrane adhesion GO:0099179
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
1 D3ZE55 (/IMP)
Regulation of synaptic membrane adhesion GO:0099179
Any process that modulates the frequency, rate or extent of adhesion between pre- and post-synaptic membranes.
1 Q7TSK3 (/ISO)

There are 34 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
52 A0A0A6YW27 (/IDA) A0A0A6YXT1 (/IDA) A0A0A6YY44 (/IDA) B9EKB6 (/IDA) O88192 (/IDA) O88193 (/IDA) O88689 (/IDA) O88690 (/IDA) Q5DTQ9 (/IDA) Q641K6 (/IDA)
(42 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
21 O95206 (/TAS) Q767I5 (/TAS) Q91XX1 (/TAS) Q9UN72 (/TAS) Q9UN73 (/TAS) Q9UN74 (/TAS) Q9Y5E3 (/TAS) Q9Y5E5 (/TAS) Q9Y5E6 (/TAS) Q9Y5E7 (/TAS)
(11 more)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
13 A0PJT6 (/ISS) E9PX28 (/ISS) E9PXQ7 (/ISS) Q5DRC8 (/ISS) Q5DRE5 (/ISS) Q6P0A6 (/ISS) Q7TSK3 (/ISS) Q80TE2 (/ISS) Q91Y07 (/ISS) Q925I8 (/ISS)
(3 more)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
12 Q91Y03 (/NAS) Q9NRJ7 (/NAS) Q9UN67 (/NAS) Q9Y5E1 (/NAS) Q9Y5E3 (/NAS) Q9Y5E4 (/NAS) Q9Y5E5 (/NAS) Q9Y5E6 (/NAS) Q9Y5E7 (/NAS) Q9Y5E9 (/NAS)
(2 more)
Endoplasmic reticulum GO:0005783
The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
6 B9EJ92 (/IDA) O88689 (/IDA) Q05C01 (/IDA) Q641K6 (/IDA) Q91Y17 (/IDA) Q91Y21 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
6 A0A140LG84 (/IDA) A0A2R8QME5 (/IDA) A1L1W7 (/IDA) C4P340 (/IDA) C4P341 (/IDA) F8W3X3 (/IDA)
Photoreceptor connecting cilium GO:0032391
The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone.
6 Q14BM8 (/IDA) Q8C8Z3 (/IDA) Q8CB45 (/IDA) Q91XZ8 (/IDA) Q91Y03 (/IDA) Q925L0 (/IDA)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
5 A0PJT6 (/IDA) Q6NXW8 (/IDA) Q91XY7 (/IDA) Q91Y07 (/IDA) Q9Z1B0 (/IDA)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
5 D3ZE55 (/IDA) O88689 (/IDA) Q14BM8 (/IDA) Q8CB45 (/IDA) Q91Y03 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 A0A0B5JFG8 (/IDA) A0A2R8Q566 (/IDA) A9QUV5 (/IDA) F1QRP2 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
4 D3ZE55 (/IDA) E9PXF0 (/IDA) Q3UTP0 (/IDA) Q5HZI5 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
4 D3ZE55 (/IMP) E9PXF0 (/IMP) Q3UTP0 (/IMP) Q5HZI5 (/IMP)
Integral component of postsynaptic membrane GO:0099055
The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 D3ZE55 (/IDA) E9PXF0 (/IDA) Q3UTP0 (/IDA) Q5HZI5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 B9EJ92 (/IDA) Q05C01 (/IDA) Q91Y17 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q6NXW8 (/ISS) Q91XY7 (/ISS) Q9Z1B0 (/ISS)
Postsynaptic membrane GO:0045211
A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane.
3 Q14BM8 (/IDA) Q8CB45 (/IDA) Q91Y03 (/IDA)
Photoreceptor disc membrane GO:0097381
Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.
3 Q14BM8 (/IDA) Q8CB45 (/IDA) Q91Y03 (/IDA)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
3 E9PXF0 (/IDA) Q3UTP0 (/IDA) Q5HZI5 (/IDA)
GABA-ergic synapse GO:0098982
A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory.
3 E9PXF0 (/IMP) Q3UTP0 (/IMP) Q5HZI5 (/IMP)
Integral component of presynaptic membrane GO:0099056
The component of the presynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
3 E9PXF0 (/IDA) Q3UTP0 (/IDA) Q5HZI5 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q91XZ4 (/IDA) Q91Y13 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q9UN70 (/NAS) Q9UN71 (/NAS)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
2 Q7TQF1 (/IDA) Q91XX8 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 Q767I5 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q767I5 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 O95206 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q8VHR0 (/NAS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q91XX1 (/TAS)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 Q7TSK3 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q9Y5G0 (/HDA)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 D3ZE55 (/EXP)
Schaffer collateral - CA1 synapse GO:0098685
A synapse between the Schaffer collateral axon of a CA3 pyramidal cell and a CA1 pyramidal cell.
1 Q7TSK3 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 Q7TSK3 (/ISO)
Integral component of postsynaptic membrane GO:0099055
The component of the postsynaptic membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q7TSK3 (/ISO)