The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Interleukin-7 receptor subunit alpha

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
1 P16871 (/TAS)
Cytokine receptor activity GO:0004896
Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 P16871 (/IDA)
Cytokine receptor activity GO:0004896
Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 P16872 (/ISO)
Interleukin-7 receptor activity GO:0004917
Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
1 P16871 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 P16871 (/IPI)

There are 25 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of DNA recombination GO:0000018
Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents.
1 P16871 (/TAS)
Cell morphogenesis GO:0000902
The developmental process in which the size or shape of a cell is generated and organized.
1 P16872 (/IGI)
Negative regulation of T cell mediated cytotoxicity GO:0001915
Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity.
1 P16872 (/IMP)
Immunoglobulin production GO:0002377
The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
1 P16872 (/IGI)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
1 P16871 (/TAS)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 P16871 (/TAS)
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
1 P16871 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P16871 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P16872 (/ISO)
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
1 P16872 (/IDA)
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
1 P16872 (/IGI)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 P16872 (/IMP)
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
1 P16872 (/IGI)
T cell differentiation GO:0030217
The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex.
1 P16872 (/IMP)
Positive regulation of T cell differentiation in thymus GO:0033089
Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus.
1 P16872 (/IMP)
Interleukin-7-mediated signaling pathway GO:0038111
A series of molecular signals initiated by the binding of interleukin-7 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
1 P16871 (/TAS)
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
1 P16872 (/IGI)
B cell proliferation GO:0042100
The expansion of a B cell population by cell division. Follows B cell activation.
1 P16872 (/IMP)
Lymph node development GO:0048535
The process whose specific outcome is the progression of lymph nodes over time, from their formation to the mature structure. A lymph node is a round, oval, or bean shaped structure localized in clusters along the lymphatic vessels, with a distinct internal structure including specialized vasculature and B- and T-zones for the activation of lymphocytes.
1 P16872 (/IMP)
Homeostasis of number of cells GO:0048872
Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.
1 P16872 (/IGI)
Homeostasis of number of cells GO:0048872
Any biological process involved in the maintenance of the steady-state number of cells within a population of cells.
1 P16872 (/IMP)
Membrane organization GO:0061024
A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins.
1 P16871 (/TAS)
Negative regulation of T cell apoptotic process GO:0070233
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell death by apoptotic process.
1 P16872 (/IMP)
Positive regulation of receptor signaling pathway via STAT GO:1904894
Any process that activates or increases the frequency, rate or extent of receptor signaling pathway via STAT.
1 P16871 (/IDA)
Positive regulation of receptor signaling pathway via STAT GO:1904894
Any process that activates or increases the frequency, rate or extent of receptor signaling pathway via STAT.
1 P16872 (/ISO)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P16871 (/TAS) P16872 (/TAS)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 P16872 (/IDA)
Clathrin-coated vesicle membrane GO:0030665
The lipid bilayer surrounding a clathrin-coated vesicle.
1 P16871 (/TAS)