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CATH Superfamily 2.60.40.180

Transthyretin/hydroxyisourate hydrolase domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Transthyretin/hydroxyisourate hydrolase domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Uric acid degradation bifunctional protein TTL

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase. [EC: 4.1.1.97]
5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate = (S)- allantoin + CO(2).
  • This enzyme is part of the pathway from urate to (S)-allantoin, which is present in bacteria, plants and animals (but not in humans).
  • Formerly EC 4.1.1.n1.
 1 Q9LVM5
Hydroxyisourate hydrolase. [EC: 3.5.2.17]
5-hydroxyisourate + H(2)O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro- 1H-imidazole-5-carboxylate.
  • The reaction is the first stage in the conversion of 5-hydroxyisourate into (S)-allantoin.
  • This reaction will also occur spontaneously, but more slowly.
 1 Q9LVM5