The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Na, k-atpase alpha subunit.
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Sodium/potassium-transporting ATPase subunit beta

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
4 P13638 (/IDA) P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
ATPase activator activity GO:0001671
Binds to and increases the ATP hydrolysis activity of an ATPase.
3 P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 P14415 (/IPI) P14415 (/IPI) P14415 (/IPI)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
3 P14415 (/IPI) P14415 (/IPI) P14415 (/IPI)
ATPase activator activity GO:0001671
Binds to and increases the ATP hydrolysis activity of an ATPase.
2 P14231 (/ISO) P14231 (/ISO)
Sodium:potassium-exchanging ATPase activity GO:0005391
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in).
2 P14231 (/ISO) P14231 (/ISO)
ATPase binding GO:0051117
Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
2 P14231 (/ISO) P14231 (/ISO)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
3 P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
Cellular potassium ion homeostasis GO:0030007
Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
3 P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
3 P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
Ion transmembrane transport GO:0034220
A process in which an ion is transported across a membrane.
3 P14415 (/TAS) P14415 (/TAS) P14415 (/TAS)
Sodium ion export across plasma membrane GO:0036376
The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
3 P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
3 P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
3 P14415 (/TAS) P14415 (/TAS) P14415 (/TAS)
Membrane repolarization GO:0086009
The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.
3 P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
Cell communication by electrical coupling involved in cardiac conduction GO:0086064
The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction.
3 P14415 (/TAS) P14415 (/TAS) P14415 (/TAS)
Positive regulation of potassium ion transmembrane transporter activity GO:1901018
Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity.
3 P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
Positive regulation of sodium ion export across plasma membrane GO:1903278
Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.
3 P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
Positive regulation of potassium ion import across plasma membrane GO:1903288
Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane.
3 P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
Regulation of cardiac conduction GO:1903779
Any process that modulates the frequency, rate or extent of cardiac conduction.
3 P14415 (/TAS) P14415 (/TAS) P14415 (/TAS)
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
3 P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
Cellular sodium ion homeostasis GO:0006883
Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell.
2 P14231 (/ISO) P14231 (/ISO)
Cellular potassium ion homeostasis GO:0030007
Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell.
2 P14231 (/ISO) P14231 (/ISO)
Positive regulation of ATPase activity GO:0032781
Any process that activates or increases the rate of ATP hydrolysis by an ATPase.
2 P14231 (/ISO) P14231 (/ISO)
Sodium ion export across plasma membrane GO:0036376
The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.
2 P14231 (/ISO) P14231 (/ISO)
Protein stabilization GO:0050821
Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation.
2 P14231 (/ISO) P14231 (/ISO)
Membrane repolarization GO:0086009
The process in which ions are transported across a membrane such that the membrane potential changes in the repolarizing direction, toward the steady state potential. For example, the repolarization during an action potential is from a positive membrane potential towards a negative resting potential.
2 P14231 (/ISO) P14231 (/ISO)
Positive regulation of potassium ion transmembrane transporter activity GO:1901018
Any process that activates or increases the frequency, rate or extent of potassium ion transmembrane transporter activity.
2 P14231 (/ISO) P14231 (/ISO)
Positive regulation of sodium ion export across plasma membrane GO:1903278
Any process that activates or increases the frequency, rate or extent of sodium ion export across the plasma membrane.
2 P14231 (/ISO) P14231 (/ISO)
Positive regulation of potassium ion import across plasma membrane GO:1903288
Any process that activates or increases the frequency, rate or extent of potassium ion import across the plasma membrane.
2 P14231 (/ISO) P14231 (/ISO)
Potassium ion import across plasma membrane GO:1990573
The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol.
2 P14231 (/ISO) P14231 (/ISO)
Startle response GO:0001964
An action or movement due to the application of a sudden unexpected stimulus.
1 Q90Z34 (/IGI)
Startle response GO:0001964
An action or movement due to the application of a sudden unexpected stimulus.
1 Q90Z34 (/IMP)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q90Z34 (/IGI)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q90Z34 (/IMP)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
1 Q90Z34 (/IGI)
Inner ear morphogenesis GO:0042472
The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively.
1 Q90Z34 (/IMP)
Otolith development GO:0048840
The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure.
1 Q90Z34 (/IGI)
Otolith development GO:0048840
The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure.
1 Q90Z34 (/IMP)
Posterior lateral line neuromast hair cell differentiation GO:0048923
The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons.
1 Q90Z34 (/IGI)
Posterior lateral line neuromast hair cell differentiation GO:0048923
The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons.
1 Q90Z34 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 P14415 (/TAS) P14415 (/TAS) P14415 (/TAS)
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
3 P14415 (/IDA) P14415 (/IDA) P14415 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
3 P13638 (/IDA) P14231 (/IDA) P14231 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P14231 (/IDA) P14231 (/IDA)
Sodium:potassium-exchanging ATPase complex GO:0005890
Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior.
2 P14231 (/ISO) P14231 (/ISO)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 P14231 (/ISO) P14231 (/ISO)