The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
C2 domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
1463
3D
2q3xB00 - 88.5
2
1177
3D
6nytA00 - 93.4
3
986
3D
1v27A00 - 92.7
4
853
3D
4kitB06 - 96.1
5
836
3D
3hn8C02 - 85.7
7
835
3D
5vfgA00 - 89.5
6
830
3D
3fdwB00 - 98.4
8
809
3D
4qj5B04 - 95.1
9
784 - - 86.4
10
759 - - 81.1
11
739
3D
3hn8C01 - 92.7
12
739
3D
4dnlA00 - 84.0
13
698 - - 85.4
14
624 - - 93.5
16
598
3D
5vfeB00 - 90.4
15
590 - - 75.4
17
517 - - 79.0
18
514 - - 90.3
19
492
3D
2ep6A01 - 87.2
20
485 - - 28.6
21
454 - - 70.9
22
444 - - 80.3
23
442
3D
2k3hA00 - 84.8
24
416
3D
3pycA00 - 85.1
25
415
3D
4p42A02 - 93.6
26
393 - - 87.9
27
393
3D
2d8kA00 - 73.3
28
389
3D
3n5aA00 - 84.3
29
381
3D
3jzyA00 - 78.2
30
371
3D
1rlwA00 - 94.9
31
360
3D
2cjtD00 - 79.9
32
359
3D
5lowJ00 - 89.5
33
333 - - 70.6
34
332 - - 90.0
36
325
3D
6bu0C00 - 84.8
35
325 - - 67.1
37
309 - - 74.6
38
308 - - 71.7
41
303
3D
4yknA05 - 85.1
39
302
3D
1w16A00 - 94.4
40
298 - - 84.2
46
288
3D
5dxuA02 - 92.9
43
275 - - 81.0
42
275 - - 94.2
44
265
3D
3l4cB00 - 78.7
45
260 - - 91.3
47
257
3D
2nsqA00 - 76.0
48
256
3D
4kitB12 - 86.8
49
249
3D
1yrkA00 - 90.7
50
245 - - 92.6
51
242
3D
1ugkA00 - 87.1
52
237 - - 54.4
87
236
3D
6c1sA02 - 91.9
53
215
3D
2enpA00 - 85.3
54
209 - - 82.9
61
207
3D
4iqhC00 - 55.7
56
206
3D
2fk9A00 - 89.2
55
205 - - 88.0
59
205
3D
2qz5B00 - 93.3
57
203 - - 53.1
58
202 - - 91.7
60
200 - - 86.3
62
198 - - 87.5
63
190 - - 72.0
64
190 - - 82.2
65
189 - - 96.7
66
189 - - 89.3
68
188 - - 76.4
67
188 - - 84.4
69
182 - - 83.8
70
181 - - 87.3
71
171 - - 71.8
73
170
3D
2yrbA01 - 84.3
72
169 - - 62.2
74
166 - - 73.9
75
163 - - 74.5
76
161 - - 83.8
78
160
3D
2dmgA00 - 74.1
77
160 - - 74.8
84
156
3D
6fjdB00 - 82.5
79
154 - - 75.2
80
151 - - 79.1
82
150 - - 77.3
81
150 - - 50.6
83
148 - - 83.8
85
146 - - 86.2
86
144 - - 64.6
98
144
3D
2isdB04 - 75.6
91
139
3D
4p42A03 - 79.2
89
137 - - 52.3
88
137 - - 84.2
90
135 - - 88.5
92
134
3D
2nq3A00 - 79.7
93
130 - - 95.3
95
129
3D
6eelC00 - 43.2
94
125 - - 74.6
96
124 - - 76.3
99
122 - - 88.1
97
122 - - 56.8
100
121 - - 98.6
101
119 - - 95.1
102
118 - - 92.4
103
116 - - 76.9
105
115
3D
2zkmX04 - 78.1
104
114 - - 72.8
106
113 - - 90.2
107
109 - - 77.4
112
106
3D
6fljA00 - 58.9
111
106
3D
5h4zB00 - 78.4
108
106 - - 90.0
109
105 - - 39.1
110
103 - - 52.2
113
101 - - 96.1
114
100 - - 89.1
115
97 - - 12.2
116
96 - - 70.3
118
94
3D
3l9bA00 - 54.0
117
93 - - 29.7
119
92 - - 86.9
120
91 - - 70.1
121
90 - - 71.7
122
89 - - 71.9
123
89 - - 46.1
133
88
3D
5lj5B12 - 98.2
124
86 - - 83.9
125
83 - - 73.1
128
82 - - 81.9
126
82 - - 34.6
127
82 - - 47.0
129
81 - - 74.5
131
81 - - 95.4
130
81 - - 76.0
132
80 - - 67.6
134
76 - - 37.4
137
76
3D
1rh8A00 - 75.4
136
75 - - 71.5
135
75 - - 80.7
138
73 - - 88.6
139
71 - - 75.1
141
65 - - 37.3
140
65 - - 85.6
142
64 - - 72.8
143
64 - - 59.1
144
62 - - 43.1
145
62
3D
1wfmA00 - 77.8
147
60 - - 72.3
146
60 - - 59.2
149
58 - - 95.8
148
58 - - 54.5
151
57 - - 79.9
150
57 - - 67.6
152
55 - - 77.8
153
54 - - 66.9
155
54 - - 88.0
154
54 - - 40.4
158
53 - - 88.1
157
53 - - 36.8
156
53 - - 79.8
159
53 - - 34.8
161
52 - - 67.5
160
52 - - 71.7
162
51 - - 71.0
163
50 - - 73.8
164
50 - - 43.4
165
49 - - 21.6
166
48 - - 74.7
167
46 - - 77.4
168
45 - - 92.3
169
Npl1
42 - - 75.0
170
41 - - 61.8
171
40 - - 69.4
173
40 - - 90.0
172
40 - - 55.4
174
39 - - 93.4
175
38 - - 39.0
177
37 - - 59.0
176
37 - - 92.8
178
36 - - 25.7
179
36 - - 86.8
181
35 - - 86.3
180
35 - - 75.4
182
35 - - 87.4
183
32 - - 93.5
184
31 - - 73.7
185
31 - - 18.5
186
29 - - 82.1
187
29 - - 71.2
188
29 - - 79.0
189
29
3D
4qamB00 - 54.1
191
27 - - 70.3
192
27 - - 60.8
190
27 - - 56.0
193
26 - - 72.7
194
26 - - 75.8
195
26 - - 17.0
196
25 - - 70.6
216
25
3D
5ug7A00 - 67.1
199
24 - - 85.3
198
24 - - 75.8
202
24 - - 95.2
200
24 - - 17.0
197
24 - - 73.6
201
24 - - 77.3
203
CaLB domain
23 - - 21.1
204
22 - - 20.1
207
21 - - 80.6
209
21 - - 92.6
205
21 - - 62.9
210
21 - - 94.8
206
21 - - 22.7
208
21 - - 85.2
222
20 - - 89.9
217
20 - - 89.4
214
20 - - 80.9
215
20 - - 8.5
212
20 - - 69.2
213
20 - - 45.1
211
20 - - 78.5
218
20 - - 77.6
221
20 - - 87.3
219
20 - - 95.6
220
20 - - 76.4
225
19 - - 10.0
224
19 - - 4.9
226
19 - - 79.5
223
19 - - 76.0
227
18 - - 4.1
229
18 - - 3.0
228
18 - - 21.8
230
18 - - 74.2
231
18 - - 92.0
232
17 - - 0.0
233
17 - - 14.0
236
17 - - 18.5
234
17 - - 19.5
237
17 - - 96.1
235
17 - - 24.4
238
16 - - 74.3
240
16 - - 27.5
239
16 - - 32.7
244
15 - - 60.5
242
CaLB domain
15 - - 30.3
243
15 - - 91.3
241
15 - - 83.3
263
14
3D
3fbkB00 - 90.7
248
14 - - 20.2
246
14 - - 41.8
247
14 - - 0.0
245
14 - - 14.6
252
13 - - 51.7
253
13 - - 12.0
258
13 - - 7.3
249
13 - - 75.7
256
13 - - 83.3
257
13 - - 45.5
254
13 - - 12.2
255
13 - - 71.4
250
13 - - 10.3
251
13 - - 2.9
262
12 - - 31.4
260
12 - - 63.9
264
12 - - 84.9
259
PIK-A
12 - - 18.4
265
12 - - 2.8
261
12 - - 50.6
272
11 - - 76.6
365
11
3D
5lj5B06 - 7.1
267
11 - - 11.3
273
11 - - 97.4
270
11 - - 5.8
271
11 - - 4.6
268
11 - - 15.1
269
11 - - 2.9
266
11 - - 65.1
278
10 - - 4.9
281
10 - - 70.3
279
10 - - 0.0
280
10 - - 9.5
288
10 - - 75.5
283
10 - - 8.9
282
10 - - 14.6
285
10 - - 50.3
284
10 - - 8.0
289
10 - - 89.0
290
DUF3451
10 - - 41.3
287
10 - - 66.5
274
10 - - 81.3
276
10 - - 9.8
286
10 - - 20.8
275
10 - - 49.7
291
10 - - 76.1
277
10 - - 65.5
294
9 - - 78.9
293
9 - - 74.7
297
9 - - 8.7
295
9 - - 71.4
300
9 - - 69.0
296
9 - - 22.4
301
9 - - 75.5
299
9 - - 12.8
302
9 - - 13.9
298
9 - - 2.7
303
9 - - 18.0
292
9 - - 44.7
304
9 - - 22.9
311
8 - - 1.0
326
8 - - 83.9
305
8 - - 1.7
319
8 - - 23.7
310
8 - - 11.3
318
8 - - 15.2
320
8 - - 15.5
321
8 - - 17.0
306
8 - - 61.0
308
8 - - 36.4
323
8 - - 70.8
307
8 - - 77.1
315
8 - - 13.5
317
8 - - 8.1
309
8 - - 85.9
322
8 - - 38.9
316
8 - - 15.6
314
8 - - 70.8
325
8 - - 23.5
313
8 - - 46.4
324
8 - - 11.8
312
8 - - 33.3
335
7 - - 2.2
344
7 - - 11.2
336
7 - - 3.4
329
7 - - 40.4
346
7 - - 83.5
334
7 - - 4.1
345
7 - - 5.7
337
7 - - 6.0
338
7 - - 1.1
328
7 - - 90.3
343
7 - - 4.5
340
7 - - 10.9
349
7 - - 95.1
330
7 - - 12.2
342
7 - - 1.6
341
7 - - 3.7
339
7 - - 6.1
333
PKN
7 - - 21.2
347
7 - - 35.5
331
7 - - 10.3
348
7 - - 88.5
332
7 - - 14.9
327
7 - - 5.7
350
6 - - 33.9
359
6 - - 52.8
351
6 - - 84.7
362
6 - - 16.4
364
6 - - 16.1
352
6 - - 85.0
366
6 - - 5.3
360
6 - - 0.7
353
6 - - 46.5
361
6 - - 78.8
367
6 - - 14.8
354
6 - - 4.9
355
6 - - 14.2
356
6 - - 15.0
363
6 - - 43.1
357
6 - - 16.8
358
6 - - 53.6
368
6 - - 48.3
395
5 - - 92.5
383
5 - - 41.5
382
5 - - 13.4
405
5 - - 68.6
392
5 - - 74.1
376
5 - - 29.4
371
5 - - 52.9
400
5 - - 67.3
385
5 - - 83.2
377
5 - - 28.4
397
5 - - 8.1
401
5 - - 76.5
394
5 - - 94.3
374
5 - - 0.0
384
5 - - 73.7
391
5 - - 0.0
375
5 - - 72.8
387
5 - - 9.6
399
5 - - 68.4
386
5 - - 75.2
372
5 - - 20.2
402
5 - - 69.4
396
5 - - 12.2
378
5 - - 40.4
389
5 - - 7.2
381
5 - - 7.9
373
5 - - 17.5
393
5 - - 48.1
404
5 - - 86.4
390
5 - - 12.2
388
5 - - 0.0
379
5 - - 17.0
370
5 - - 19.2
380
5 - - 11.7
369
5 - - 0.9
398
5 - - 21.9
403
5 - - 42.4
413
4 - - 41.9
425
4 - - 89.9
412
4 - - 26.2
419
4 - - 7.8
406
4 - - 3.0
408
4 - - 48.9
414
4 - - 39.2
407
4 - - 7.5
415
4 - - 45.4
416
4 - - 38.8
409
4 - - 70.1
420
4 - - 17.5
421
4 - - 12.5
423
4 - - 73.9
422
4 - - 10.0
410
4 - - 17.0
417
4 - - 11.4
424
4 - - 64.3
418
4 - - 13.1
411
4 - - 10.0
458
3 - - 0.0
468
3 - - 61.2
432
3 - - 72.9
461
3 - - 4.2
440
3 - - 71.1
467
3 - - 63.3
457
3 - - 1.0
431
3 - - 69.8
453
3 - - 0.0
427
3 - - 23.5
426
3 - - 7.9
462
3 - - 8.2
469
3 - - 67.3
439
3 - - 15.8
451
3 - - 0.0
430
3 - - 34.4
447
3 - - 0.0
438
3 - - 37.1
442
3 - - 0.8
465
3 - - 46.6
470
3 - - 63.3
437
3 - - 34.4
460
3 - - 4.5
452
3 - - 12.6
441
3 - - 41.9
428
3 - - 0.7
429
3 - - 15.2
466
3 - - 29.9
463
3 - - 46.0
444
3 - - 0.0
456
3 - - 0.0
449
3 - - 0.0
443
3 - - 6.1
436
3 - - 4.6
464
3 - - 40.7
435
3 - - 16.9
448
CaLB domain
3 - - 4.2
450
3 - - 10.3
454
3 - - 0.0
446
3 - - 15.0
434
3 - - 6.9
459
3 - - 0.8
455
3 - - 0.0
445
3 - - 3.7
433
3 - - 4.5
495
2 - - 0.8
486
2 - - 14.5
558
CaLB domain
2 - - 0.0
573
2 - - 15.4
506
2 - - 10.6
581
2 - - 36.4
588
2 - - 39.5
542
2 - - 0.0
526
2 - - 38.2
490
2 - - 5.0
532
2 - - 0.0
474
2 - - 10.0
563
2 - - 0.0
472
2 - - 0.0
505
2 - - 0.0
570
2 - - 2.8
559
2 - - 5.3
580
2 - - 31.6
523
2 - - 0.0
595
2 - - 46.1
507
2 - - 3.6
525
2 - - 43.4
498
2 - - 0.0
483
2 - - 0.0
533
2 - - 10.0
543
2 - - 9.4
565
2 - - 3.7
471
2 - - 4.8
562
2 - - 0.0
473
2 - - 0.0
560
2 - - 2.2
578
2 - - 20.5
540
2 - - 12.2
571
2 - - 0.0
594
2 - - 44.0
493
2 - - 10.0
519
2 - - 25.3
556
2 - - 0.0
549
2 - - 11.4
583
2 - - 40.5
591
2 - - 43.3
479
2 - - 15.1
576
2 - - 0.0
484
2 - - 29.7
561
2 - - 0.0
530
2 - - 1.3
527
2 - - 39.4
548
2 - - 0.0
579
2 - - 30.0
541
2 - - 0.0
496
2 - - 0.0
582
2 - - 37.9
557
2 - - 0.0
590
MKS
2 - - 41.9
500
2 - - 0.9
513
2 - - 22.5
489
2 - - 44.7
585
2 - - 12.6
518
2 - - 20.5
478
2 - - 33.8
531
2 - - 3.2
577
2 - - 0.0
512
2 - - 14.0
517
2 - - 24.1
569
2 - - 0.8
536
2 - - 0.0
508
2 - - 7.4
545
2 - - 3.0
574
2 - - 0.0
566
2 - - 5.7
477
2 - - 10.0
501
2 - - 0.0
539
2 - - 0.0
520
2 - - 24.5
584
2 - - 42.0
554
2 - - 14.2
552
2 - - 38.8
481
2 - - 12.5
546
2 - - 1.8
537
2 - - 4.0
529
2 - - 0.0
491
2 - - 0.0
509
2 - - 6.3
488
2 - - 40.1
568
2 - - 0.0
476
2 - - 10.6
575
2 - - 7.3
511
2 - - 2.2
502
2 - - 11.4
553
2 - - 43.1
555
2 - - 3.2
593
2 - - 40.5
587
2 - - 42.6
494
2 - - 2.3
487
2 - - 34.4
547
2 - - 7.4
482
2 - - 0.0
499
2 - - 0.9
528
2 - - 17.9
586
2 - - 41.5
480
2 - - 6.6
534
2 - - 3.8
475
2 - - 0.8
515
2 - - 25.6
510
2 - - 14.8
524
2 - - 39.8
564
2 - - 0.9
503
2 - - 1.0
544
2 - - 0.0
522
2 - - 26.8
516
2 - - 15.5
550
2 - - 33.6
592
2 - - 41.2
572
2 - - 0.0
485
2 - - 21.7
535
2 - - 2.5
567
2 - - 0.0
514
2 - - 21.2
589
2 - - 44.9
492
2 - - 0.0
538
2 - - 0.0
521
2 - - 25.9
497
2 - - 0.0
551
2 - - 39.0
504
2 - - 0.0
728
1 - - 0.0
825
1 - - 0.0
686
1 - - 0.0
690
1 - - 0.0
638
1 - - 0.0
661
1 - - 0.0
678
1 - - 0.0
652
1 - - 0.0
775
1 - - 0.0
700
1 - - 0.0
764
1 - - 0.0
606
1 - - 0.0
708
1 - - 0.0
710
1 - - 0.0
756
1 - - 0.0
659
1 - - 0.0
788
1 - - 0.0
782
1 - - 0.0
781
1 - - 0.0
649
1 - - 0.0
642
1 - - 0.0
776
1 - - 0.0
748
1 - - 0.0
711
1 - - 0.0
741
1 - - 0.0
729
1 - - 0.0
735
1 - - 0.0
600
1 - - 0.0
670
1 - - 0.0
625
1 - - 0.0
763
1 - - 0.0
675
1 - - 0.0
662
1 - - 0.0
716
1 - - 0.0
685
1 - - 0.0
813
1 - - 0.0
644
1 - - 0.0
791
1 - - 0.0
787
1 - - 0.0
769
1 - - 0.0
803
1 - - 0.0
691
1 - - 0.0
650
1 - - 0.0
790
1 - - 0.0
635
1 - - 0.0
709
1 - - 0.0
757
1 - - 0.0
603
1 - - 0.0
680
1 - - 0.0
820
1 - - 0.0
770
1 - - 0.0
641
1 - - 0.0
616
1 - - 0.0
777
1 - - 0.0
609
1 - - 0.0
726
1 - - 0.0
624
1 - - 0.0
814
1 - - 0.0
749
1 - - 0.0
613
1 - - 0.0
802
1 - - 0.0
798
1 - - 0.0
695
1 - - 0.0
758
1 - - 0.0
706
1 - - 0.0
784
1 - - 0.0
762
1 - - 0.0
633
1 - - 0.0
646
1 - - 0.0
810
1 - - 0.0
806
1 - - 0.0
717
1 - - 0.0
671
1 - - 0.0
663
1 - - 0.0
811
1 - - 0.0
819
1 - - 0.0
619
1 - - 0.0
621
1 - - 0.0
602
1 - - 0.0
612
1 - - 0.0
701
1 - - 0.0
731
1 - - 0.0
768
1 - - 0.0
761
1 - - 0.0
738
1 - - 0.0
623
1 - - 0.0
628
1 - - 0.0
733
1 - - 0.0
630
1 - - 0.0
608
1 - - 0.0
714
1 - - 0.0
823
1 - - 0.0
771
1 - - 0.0
654
1 - - 0.0
767
1 - - 0.0
805
1 - - 0.0
783
1 - - 0.0
789
1 - - 0.0
715
1 - - 0.0
778
1 - - 0.0
720
1 - - 0.0
605
1 - - 0.0
759
1 - - 0.0
694
1 - - 0.0
672
1 - - 0.0
751
1 - - 0.0
677
1 - - 0.0
664
1 - - 0.0
651
1 - - 0.0
632
1 - - 0.0
797
1 - - 0.0
645
1 - - 0.0
687
1 - - 0.0
826
1 - - 0.0
620
1 - - 0.0
730
1 - - 0.0
812
1 - - 0.0
732
1 - - 0.0
622
1 - - 0.0
740
1 - - 0.0
688
1 - - 0.0
750
1 - - 0.0
804
1 - - 0.0
779
1 - - 0.0
697
1 - - 0.0
707
1 - - 0.0
760
1 - - 0.0
721
1 - - 0.0
669
1 - - 0.0
643
1 - - 0.0
618
1 - - 0.0
722
1 - - 0.0
742
1 - - 0.0
796
1 - - 0.0
666
1 - - 0.0
660
1 - - 0.0
604
1 - - 0.0
766
1 - - 0.0
682
1 - - 0.0
626
1 - - 0.0
809
1 - - 0.0
736
1 - - 0.0
665
1 - - 0.0
648
1 - - 0.0
704
1 - - 0.0
681
1 - - 0.0
817
1 - - 0.0
673
1 - - 0.0
808
1 - - 0.0
636
1 - - 0.0
821
1 - - 0.0
696
1 - - 0.0
712
1 - - 0.0
655
1 - - 0.0
597
1 - - 0.0
739
1 - - 0.0
772
1 - - 0.0
653
1 - - 0.0
743
1 - - 0.0
723
1 - - 0.0
824
1 - - 0.0
629
1 - - 0.0
615
1 - - 0.0
699
1 - - 0.0
818
1 - - 0.0
795
1 - - 0.0
794
1 - - 0.0
674
1 - - 0.0
679
1 - - 0.0
647
1 - - 0.0
640
1 - - 0.0
705
1 - - 0.0
785
1 - - 0.0
599
1 - - 0.0
753
1 - - 0.0
656
1 - - 0.0
829
1 - - 0.0
596
1 - - 0.0
713
1 - - 0.0
631
1 - - 0.0
807
1 - - 0.0
634
1 - - 0.0
684
1 - - 0.0
734
1 - - 0.0
773
1 - - 0.0
746
1 - - 0.0
744
1 - - 0.0
724
1 - - 0.0
815
1 - - 0.0
692
1 - - 0.0
658
1 - - 0.0
614
1 - - 0.0
828
1 - - 0.0
689
1 - - 0.0
727
1 - - 0.0
801
1 - - 0.0
754
1 - - 0.0
698
1 - - 0.0
598
1 - - 0.0
780
1 - - 0.0
657
1 - - 0.0
667
1 - - 0.0
702
1 - - 0.0
793
1 - - 0.0
799
1 - - 0.0
737
1 - - 0.0
627
1 - - 0.0
637
1 - - 0.0
752
1 - - 0.0
683
1 - - 0.0
765
1 - - 0.0
800
1 - - 0.0
607
1 - - 0.0
816
1 - - 0.0
718
1 - - 0.0
617
1 - - 0.0
610
1 - - 0.0
725
1 - - 0.0
745
1 - - 0.0
611
1 - - 0.0
747
1 - - 0.0
786
1 - - 0.0
719
1 - - 0.0
827
1 - - 0.0
668
1 - - 0.0
774
1 - - 0.0
693
1 - - 0.0
755
1 - - 0.0
601
1 - - 0.0
822
1 - - 0.0
792
1 - - 0.0
639
1 - - 0.0
676
1 - - 0.0
703
1 - - 0.0