The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Integrin domains. Chain A, domain 2
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: Integrin alpha 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
2 D3ZMQ3 (/IMP) Q00651 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 D3ZMQ3 (/IPI) P13612 (/IPI)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
2 D3ZMQ3 (/IMP) P13612 (/IMP)
Fibronectin binding GO:0001968
Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids.
1 Q00651 (/ISO)
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
1 D3ZMQ3 (/IPI)
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
1 Q00651 (/ISO)
Coreceptor activity GO:0015026
Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity.
1 P13612 (/TAS)
Protein heterodimerization activity GO:0046982
Interacting selectively and non-covalently with a nonidentical protein to form a heterodimer.
1 P13612 (/TAS)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 P13612 (/IPI)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
1 Q00651 (/ISO)
Protein antigen binding GO:1990405
Interacting selectively and non-covalently with a protein antigen.
1 D3ZMQ3 (/IPI)
Protein antigen binding GO:1990405
Interacting selectively and non-covalently with a protein antigen.
1 Q00651 (/ISO)

There are 65 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Blood vessel remodeling GO:0001974
The reorganization or renovation of existing blood vessels.
1 Q00651 (/IMP)
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
1 D3ZMQ3 (/IMP)
Positive regulation of leukocyte migration GO:0002687
Any process that activates or increases the frequency, rate, or extent of leukocyte migration.
1 Q00651 (/ISO)
Cell-matrix adhesion involved in ameboidal cell migration GO:0003366
The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell.
1 P13612 (/IMP)
Cell-matrix adhesion involved in ameboidal cell migration GO:0003366
The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell.
1 Q00651 (/ISO)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q00651 (/IMP)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157
The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
1 Q00651 (/IMP)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
1 P13612 (/IDA)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
1 Q00651 (/IMP)
Leukocyte cell-cell adhesion GO:0007159
The attachment of a leukocyte to another cell via adhesion molecules.
1 Q00651 (/ISO)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
1 P13612 (/IMP)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
1 Q00651 (/ISO)
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
1 Q00651 (/TAS)
Heart development GO:0007507
The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood.
1 Q00651 (/IMP)
Cell migration GO:0016477
The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
1 Q00651 (/IMP)
B cell differentiation GO:0030183
The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
1 P13612 (/IC)
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
1 P13612 (/TAS)
Cell-cell adhesion mediated by integrin GO:0033631
The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
1 P13612 (/IGI)
Cell-cell adhesion mediated by integrin GO:0033631
The attachment of one cell to another cell via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
1 Q00651 (/ISO)
Heterotypic cell-cell adhesion GO:0034113
The attachment of a cell to a cell of a different type via adhesion molecules.
1 P13612 (/IGI)
Heterotypic cell-cell adhesion GO:0034113
The attachment of a cell to a cell of a different type via adhesion molecules.
1 P13612 (/IMP)
Heterotypic cell-cell adhesion GO:0034113
The attachment of a cell to a cell of a different type via adhesion molecules.
1 Q00651 (/ISO)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
1 P13612 (/IMP)
Substrate adhesion-dependent cell spreading GO:0034446
The morphogenetic process that results in flattening of a cell as a consequence of its adhesion to a substrate.
1 Q00651 (/ISO)
Endodermal cell differentiation GO:0035987
The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.
1 P13612 (/IEP)
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
1 P13612 (/IMP)
Receptor clustering GO:0043113
The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response.
1 Q00651 (/ISO)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
1 P13612 (/TAS)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
1 P13612 (/TAS)
Leukocyte tethering or rolling GO:0050901
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
1 P13612 (/IMP)
Leukocyte tethering or rolling GO:0050901
Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection).
1 Q00651 (/ISO)
Diapedesis GO:0050904
The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation.
1 D3ZMQ3 (/IMP)
Diapedesis GO:0050904
The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation.
1 Q00651 (/ISO)
Face development GO:0060324
The biological process whose specific outcome is the progression of a face from an initial condition to its mature state. The face is the ventral division of the head.
1 Q00651 (/IMP)
Axonogenesis involved in innervation GO:0060385
The neurite development process that generates a long process of a neuron, as it invades a target tissue.
1 D3ZMQ3 (/IMP)
Axonogenesis involved in innervation GO:0060385
The neurite development process that generates a long process of a neuron, as it invades a target tissue.
1 Q00651 (/ISO)
Mesenchyme development GO:0060485
The process whose specific outcome is the progression of a mesenchymal tissue over time, from its formation to the mature structure. A mesenchymal tissue is made up of loosely packed stellate cells.
1 Q00651 (/TAS)
Chorio-allantoic fusion GO:0060710
The cell-cell adhesion process in which the cells of the chorion fuse to the cells of the allantois.
1 Q00651 (/IMP)
Visceral serous pericardium development GO:0061032
The progression of the visceral serous pericardium from its formation to the mature structure. The visceral serous pericardium is the inner layer of the pericardium.
1 Q00651 (/TAS)
Cellular response to cytokine stimulus GO:0071345
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 D3ZMQ3 (/IEP)
T cell migration GO:0072678
The movement of a T cell within or between different tissues and organs of the body.
1 Q00651 (/IMP)
Negative regulation of protein homodimerization activity GO:0090074
Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
1 P13612 (/IDA)
Negative regulation of protein homodimerization activity GO:0090074
Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
1 Q00651 (/ISO)
Negative regulation of protein homodimerization activity GO:0090074
Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.
1 Q00651 (/ISS)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 Q00651 (/TAS)
Import into cell GO:0098657
The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
1 D3ZMQ3 (/IMP)
Import into cell GO:0098657
The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
1 Q00651 (/ISO)
Cell-cell adhesion in response to extracellular stimulus GO:0140039
The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus.
1 P13612 (/IGI)
Cell-cell adhesion in response to extracellular stimulus GO:0140039
The attachment of one cell to another cell via adhesion molecules as a result of an extracellular stimulus.
1 Q00651 (/ISO)
Positive regulation of leukocyte cell-cell adhesion GO:1903039
Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion.
1 D3ZMQ3 (/IMP)
Positive regulation of leukocyte cell-cell adhesion GO:1903039
Any process that activates or increases the frequency, rate or extent of leukocyte cell-cell adhesion.
1 Q00651 (/ISO)
Positive regulation of leukocyte tethering or rolling GO:1903238
Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling.
1 D3ZMQ3 (/IMP)
Positive regulation of leukocyte tethering or rolling GO:1903238
Any process that activates or increases the frequency, rate or extent of leukocyte tethering or rolling.
1 Q00651 (/ISO)
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
1 P13612 (/IGI)
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
1 Q00651 (/ISO)
Positive regulation of vascular endothelial cell proliferation GO:1905564
Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.
1 P13612 (/IMP)
Positive regulation of vascular endothelial cell proliferation GO:1905564
Any process that activates or increases the frequency, rate or extent of vascular endothelial cell proliferation.
1 Q00651 (/ISO)
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 D3ZMQ3 (/IMP)
Neuron projection extension GO:1990138
Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 Q00651 (/ISO)
Clathrin-dependent extracellular exosome endocytosis GO:1990771
The clathrin-mediated endocytosis of an extracellular exosome.
1 D3ZMQ3 (/IMP)
Clathrin-dependent extracellular exosome endocytosis GO:1990771
The clathrin-mediated endocytosis of an extracellular exosome.
1 Q00651 (/ISO)
Positive regulation of endothelial cell apoptotic process GO:2000353
Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.
1 P13612 (/IMP)
Positive regulation of endothelial cell apoptotic process GO:2000353
Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.
1 Q00651 (/ISO)
Positive regulation of T cell migration GO:2000406
Any process that activates or increases the frequency, rate or extent of T cell migration.
1 D3ZMQ3 (/IMP)
Positive regulation of T cell migration GO:2000406
Any process that activates or increases the frequency, rate or extent of T cell migration.
1 Q00651 (/ISO)

There are 20 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 D3ZMQ3 (/IDA) P13612 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 D3ZMQ3 (/IDA) P13612 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q00651 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P13612 (/TAS)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q00651 (/IDA)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
1 P13612 (/HDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
1 Q00651 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q00651 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q00651 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P13612 (/HDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 D3ZMQ3 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 Q00651 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P13612 (/TAS)
Integrin alpha4-beta7 complex GO:0034669
An integrin complex that comprises one alpha4 subunit and one beta7 subunit.
1 P13612 (/IDA)
Integrin alpha4-beta7 complex GO:0034669
An integrin complex that comprises one alpha4 subunit and one beta7 subunit.
1 Q00651 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 D3ZMQ3 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q00651 (/ISO)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P13612 (/HDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 D3ZMQ3 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 Q00651 (/ISO)