The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Integrin domains. Chain A, domain 2
".
FunFam 6: Integrin subunit alpha 11
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 7 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
1 | Q9UKX5 (/IMP) |
|
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
1 | P61622 (/ISO) |
|
Collagen binding GO:0005518
Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).
|
1 | Q9UKX5 (/TAS) |
|
Collagen receptor activity GO:0038064
Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | Q9UKX5 (/IMP) |
|
Collagen receptor activity GO:0038064
Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
|
1 | P61622 (/ISO) |
|
Collagen binding involved in cell-matrix adhesion GO:0098639
Any collagen binding that occurs as part of cell-matrix adhesion.
|
1 | Q9UKX5 (/IMP) |
|
Collagen binding involved in cell-matrix adhesion GO:0098639
Any collagen binding that occurs as part of cell-matrix adhesion.
|
1 | P61622 (/ISO) |
There are 15 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Substrate-dependent cell migration GO:0006929
The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.
|
2 | P61622 (/IMP) Q9UKX5 (/IMP) |
|
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
|
1 | Q9UKX5 (/HDA) |
|
Substrate-dependent cell migration GO:0006929
The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate.
|
1 | P61622 (/ISO) |
|
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
|
1 | Q9UKX5 (/TAS) |
|
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
1 | Q9UKX5 (/IMP) |
|
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
1 | P61622 (/ISO) |
|
Cell-matrix adhesion GO:0007160
The binding of a cell to the extracellular matrix via adhesion molecules.
|
1 | Q9UKX5 (/TAS) |
|
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q9UKX5 (/IMP) |
|
Integrin-mediated signaling pathway GO:0007229
A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P61622 (/ISO) |
|
Muscle organ development GO:0007517
The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work.
|
1 | Q9UKX5 (/TAS) |
|
Extracellular matrix organization GO:0030198
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix.
|
1 | Q9UKX5 (/TAS) |
|
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
|
1 | Q9UKX5 (/IMP) |
|
Cell adhesion mediated by integrin GO:0033627
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via an integrin, a heterodimeric adhesion receptor formed by the non-covalent association of particular alpha and beta subunits.
|
1 | P61622 (/ISO) |
|
Collagen-activated signaling pathway GO:0038065
A series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q9UKX5 (/IMP) |
|
Collagen-activated signaling pathway GO:0038065
A series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P61622 (/ISO) |
There are 8 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | Q9UKX5 (/TAS) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | Q9UKX5 (/HDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | Q9UKX5 (/IDA) |
|
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
|
1 | P61622 (/ISO) |
|
Integrin complex GO:0008305
A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands.
|
1 | Q9UKX5 (/TAS) |
|
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
|
1 | Q9UKX5 (/HDA) |
|
Integrin alpha11-beta1 complex GO:0034681
An integrin complex that comprises one alpha11 subunit and one beta1 subunit.
|
1 | Q9UKX5 (/IDA) |
|
Integrin alpha11-beta1 complex GO:0034681
An integrin complex that comprises one alpha11 subunit and one beta1 subunit.
|
1 | P61622 (/ISO) |