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CATH Superfamily 2.60.40.1130

Rab geranylgeranyltransferase alpha-subunit, insert domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rab geranylgeranyltransferase alpha-subunit, insert domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 3 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Protein geranylgeranyltransferase type II. [EC: 2.5.1.60]
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl- protein + diphosphate.
  • This enzyme, along with EC 2.5.1.58 and EC 2.5.1.59, constitutes the protein prenyltransferase family of enzymes.
  • Attaches geranylgeranyl groups to two C-terminal cysteines in Ras- related GTPases of a single family, the Rab family (Ypt/Sec4 in lower eukaryotes) that terminate in XXCC, XCXC and CCXX motifs.
  • Reaction is entirely dependent on the Rab substrate being bound to Rab escort protein (REP).
  • Post-translational modification with the geranylgeranyl moiety is essential for Rab GTPases to be able to control the processes of membrane docking and fusion.
 7 A0A480PEZ2 A5A779 Q08602 Q5EA80 Q5NVK5 Q92696 Q9JHK4
Pullulanase. [EC: 3.2.1.41]
Hydrolysis of (1->6)-alpha-D-glucosidic linkages in pullulan, amylopectin and glycogen, and in the alpha- and beta-limit dextrins of amylopectin and glycogen.
  • Different from EC 3.2.1.142 in its action on glycogen, and its rate of hydrolysis of limit dextrins.
  • Its action on amylopectin is complete.
  • Maltose is the smallest sugar that it can release from an alpha- (1->6)-linkage.
  • Formerly EC 3.2.1.69.
 3 A0A341E8M6 P07206 P07811
Limit dextrinase. [EC: 3.2.1.142]
Hydrolysis of (1->6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan.
  • Plant enzymes with little or no action on glycogen.
  • Action on amylopectin is incomplete, but action on alpha-limit dextrins is complete.
  • Maltose is the smallest sugar it can release from an alpha-(1->6)- linkage.
 1 Q8GTR4