The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 893: Transmembrane glycoprotein NMB

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
2 Q14956 (/IDA) Q99P91 (/IDA)
Integrin binding GO:0005178
Interacting selectively and non-covalently with an integrin.
1 Q99P91 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 Q14956 (/IPI)
Heparin binding GO:0008201
Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.
1 Q99P91 (/ISO)
Chemoattractant activity GO:0042056
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.
1 Q14956 (/NAS)
Syndecan binding GO:0045545
Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.
1 Q14956 (/IPI)
Syndecan binding GO:0045545
Interacting selectively and non-covalently with syndecan, an integral membrane proteoglycan (250-300 kDa) associated largely with epithelial cells.
1 Q99P91 (/ISO)
Receptor ligand activity GO:0048018
The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands).
1 Q14956 (/IMP)
Receptor ligand activity GO:0048018
The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands).
1 Q99P91 (/ISO)

There are 33 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
2 Q14956 (/IDA) Q99P91 (/IDA)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q14956 (/IC) Q99P91 (/IC)
Osteoblast differentiation GO:0001649
The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone.
1 Q6P7C7 (/IEP)
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
1 Q14956 (/IDA)
Negative regulation of cytokine production GO:0001818
Any process that stops, prevents, or reduces the rate of production of a cytokine.
1 Q99P91 (/ISO)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 Q99P91 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 Q99P91 (/ISO)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q99P91 (/IDA)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q14956 (/IMP)
Signal transduction GO:0007165
The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
1 Q99P91 (/ISO)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
1 Q14956 (/IMP)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
1 Q99P91 (/ISO)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 Q14956 (/TAS)
Bone mineralization GO:0030282
The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue.
1 Q6P7C7 (/IEP)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q14956 (/IDA)
Positive regulation of cell migration GO:0030335
Any process that activates or increases the frequency, rate or extent of cell migration.
1 Q99P91 (/ISO)
Positive regulation of protein autophosphorylation GO:0031954
Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues.
1 Q14956 (/IDA)
Positive regulation of protein autophosphorylation GO:0031954
Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues.
1 Q99P91 (/ISO)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
1 Q99P91 (/IMP)
Regulation of tissue remodeling GO:0034103
Any process that modulates the frequency, rate, or extent of tissue remodeling.
1 Q14956 (/IDA)
Regulation of tissue remodeling GO:0034103
Any process that modulates the frequency, rate, or extent of tissue remodeling.
1 Q99P91 (/IMP)
Regulation of tissue remodeling GO:0034103
Any process that modulates the frequency, rate, or extent of tissue remodeling.
1 Q99P91 (/ISO)
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
1 Q14956 (/IDA)
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
1 Q99P91 (/ISO)
Regulation of angiogenesis GO:0045765
Any process that modulates the frequency, rate or extent of angiogenesis.
1 Q14956 (/NAS)
Negative regulation of T cell activation GO:0050868
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.
1 Q14956 (/IMP)
Negative regulation of T cell activation GO:0050868
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation.
1 Q99P91 (/ISO)
Positive chemotaxis GO:0050918
The directed movement of a motile cell or organism towards a higher concentration of a chemical.
1 Q14956 (/NAS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q99P91 (/IDA)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 Q14956 (/IGI)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 Q99P91 (/ISO)
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
1 Q14956 (/IDA)
Negative regulation of G1/S transition of mitotic cell cycle GO:2000134
Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
1 Q99P91 (/ISO)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q14956 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q99P91 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q14956 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q99P91 (/ISO)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q14956 (/TAS)
Cytoplasmic vesicle GO:0031410
A vesicle found in the cytoplasm of a cell.
1 Q99P91 (/IDA)