The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 842: Interferon receptor 1 isoform 4

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 8 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Type I interferon binding GO:0019962
Interacting selectively and non-covalently with a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.
8 P17181 (/ISS) P17181 (/ISS) Q04790 (/ISS) Q04790 (/ISS) Q28589 (/ISS) Q28589 (/ISS) Q764M8 (/ISS) Q764M8 (/ISS)
Type I interferon receptor activity GO:0004905
Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.
6 Q04790 (/ISS) Q04790 (/ISS) Q28589 (/ISS) Q28589 (/ISS) Q764M8 (/ISS) Q764M8 (/ISS)
Type I interferon receptor activity GO:0004905
Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.
4 P17181 (/IDA) P17181 (/IDA) P33896 (/IDA) P33896 (/IDA)
Interferon receptor activity GO:0004904
Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
2 P33896 (/IMP) P33896 (/IMP)
Type I interferon receptor activity GO:0004905
Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.
2 P33896 (/IMP) P33896 (/IMP)
Type I interferon receptor activity GO:0004905
Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.
2 P33896 (/ISO) P33896 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P17181 (/IPI) P17181 (/IPI)
Type I interferon binding GO:0019962
Interacting selectively and non-covalently with a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families.
2 P33896 (/IPI) P33896 (/IPI)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
8 P17181 (/ISS) P17181 (/ISS) Q04790 (/ISS) Q04790 (/ISS) Q28589 (/ISS) Q28589 (/ISS) Q764M8 (/ISS) Q764M8 (/ISS)
Cellular response to interferon-alpha GO:0035457
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
8 P17181 (/ISS) P17181 (/ISS) Q04790 (/ISS) Q04790 (/ISS) Q28589 (/ISS) Q28589 (/ISS) Q764M8 (/ISS) Q764M8 (/ISS)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
6 Q04790 (/ISS) Q04790 (/ISS) Q28589 (/ISS) Q28589 (/ISS) Q764M8 (/ISS) Q764M8 (/ISS)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
4 P17181 (/IDA) P17181 (/IDA) P33896 (/IDA) P33896 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
3 A0A0G2JXD8 (/IMP) D3ZDS9 (/IMP) D3ZDS9 (/IMP)
Receptor signaling pathway via JAK-STAT GO:0007259
Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
2 P17181 (/TAS) P17181 (/TAS)
Response to virus GO:0009615
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.
2 P17181 (/TAS) P17181 (/TAS)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P33896 (/ISO) P33896 (/ISO)
Response to lipopolysaccharide GO:0032496
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
2 P33896 (/IMP) P33896 (/IMP)
Positive regulation of interferon-beta production GO:0032728
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.
2 P33896 (/IMP) P33896 (/IMP)
Positive regulation of interferon-gamma production GO:0032729
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.
2 P33896 (/IGI) P33896 (/IGI)
Cellular response to interferon-alpha GO:0035457
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.
2 P33896 (/IMP) P33896 (/IMP)
T cell activation GO:0042110
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.
2 P33896 (/IGI) P33896 (/IGI)
Type I interferon biosynthetic process GO:0045351
The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2 P33896 (/IMP) P33896 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
2 P33896 (/IMP) P33896 (/IMP)
Positive regulation of interleukin-1 beta secretion GO:0050718
Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell.
2 P33896 (/IMP) P33896 (/IMP)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 P33896 (/IMP) P33896 (/IMP)
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
2 P33896 (/IMP) P33896 (/IMP)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2 P33896 (/IMP) P33896 (/IMP)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2 P33896 (/ISO) P33896 (/ISO)
Type I interferon signaling pathway GO:0060337
A series of molecular signals initiated by the binding of a type I interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
2 P17181 (/TAS) P17181 (/TAS)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
6 Q04790 (/ISS) Q04790 (/ISS) Q28589 (/ISS) Q28589 (/ISS) Q764M8 (/ISS) Q764M8 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P17181 (/TAS) P17181 (/TAS) P33896 (/TAS) P33896 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
4 P17181 (/IDA) P17181 (/IDA) P33896 (/IDA) P33896 (/IDA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P33896 (/ISO) P33896 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 P17181 (/TAS) P17181 (/TAS)