The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 352: Cell adhesion molecule-related/down-regulated by o...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 A4JYD4 (/IPI) F1QGR0 (/IPI) O35158 (/IPI) Q32MD9 (/IPI) Q4KMG0 (/IPI) Q6AZB0 (/IPI) Q8UVD6 (/IPI) Q9BWV1 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 A4JYD4 (/IDA) F1QGR0 (/IDA) Q8UVD6 (/IDA)

There are 40 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
4 A4JYD4 (/IMP) F1QGR0 (/IMP) Q6AZB0 (/IMP) Q8UVD6 (/IMP)
Regulation of smoothened signaling pathway GO:0008589
Any process that modulates the frequency, rate or extent of smoothened signaling.
3 A4JYD4 (/IMP) F1QGR0 (/IMP) Q8UVD6 (/IMP)
Retinal ganglion cell axon guidance GO:0031290
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.
3 A4JYD4 (/IMP) F1QGR0 (/IMP) Q8UVD6 (/IMP)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
2 O35158 (/IDA) Q6AZB0 (/IDA)
Regulation of striated muscle tissue development GO:0016202
Any process that modulates the frequency, rate or extent of striated muscle development.
2 Q32MD9 (/ISO) Q6AZB0 (/ISO)
Negative regulation of smoothened signaling pathway GO:0045879
Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling.
2 A0A0B5JK41 (/IMP) Q1L8D0 (/IMP)
Positive regulation of muscle cell differentiation GO:0051149
Any process that activates or increases the frequency, rate or extent of muscle cell differentiation.
2 Q4KMG0 (/TAS) Q9BWV1 (/TAS)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
2 Q32MD9 (/TAS) Q6AZB0 (/TAS)
Cell fate specification GO:0001708
The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.
1 Q32MD9 (/IGI)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 Q32MD9 (/IDA)
Lens development in camera-type eye GO:0002088
The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus.
1 Q32MD9 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 O35158 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q32MD9 (/ISO)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q4KMG0 (/TAS)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
1 Q32MD9 (/IGI)
Smoothened signaling pathway GO:0007224
A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
1 Q32MD9 (/ISO)
Axon guidance GO:0007411
The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.
1 Q6AZB0 (/ISO)
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 Q32MD9 (/IMP)
Anterior/posterior pattern specification GO:0009952
The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.
1 Q32MD9 (/IMP)
Embryonic body morphogenesis GO:0010172
The process in which the anatomical structures of the embryonic soma are generated and organized.
1 Q32MD9 (/IGI)
Embryonic body morphogenesis GO:0010172
The process in which the anatomical structures of the embryonic soma are generated and organized.
1 Q32MD9 (/IMP)
Skeletal muscle satellite cell differentiation GO:0014816
The process in which a relatively unspecialized cell acquires specialized features of a satellite cell.
1 Q32MD9 (/IMP)
Cerebral cortex development GO:0021987
The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon.
1 Q32MD9 (/IMP)
Cell projection organization GO:0030030
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon.
1 Q6AZB0 (/IMP)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 Q32MD9 (/IGI)
Positive regulation of MAPK cascade GO:0043410
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade.
1 Q32MD9 (/IMP)
Regulation of protein heterodimerization activity GO:0043497
Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer.
1 Q32MD9 (/IDA)
Positive regulation of myoblast differentiation GO:0045663
Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 Q6AZB0 (/IMP)
Positive regulation of myoblast differentiation GO:0045663
Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 Q9BWV1 (/ISS)
Positive regulation of myoblast differentiation GO:0045663
Any process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 Q32MD9 (/TAS)
Regulation of neuron differentiation GO:0045664
Any process that modulates the frequency, rate or extent of neuron differentiation.
1 Q32MD9 (/IMP)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
1 Q32MD9 (/IDA)
Positive regulation of neuron differentiation GO:0045666
Any process that activates or increases the frequency, rate or extent of neuron differentiation.
1 Q32MD9 (/IMP)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q32MD9 (/IGI)
Embryonic morphogenesis GO:0048598
The process in which anatomical structures are generated and organized during the embryonic phase. The embryonic phase begins with zygote formation. The end of the embryonic phase is organism-specific. For example, it would be at birth for mammals, larval hatching for insects and seed dormancy in plants.
1 Q32MD9 (/IGI)
Positive regulation of skeletal muscle tissue development GO:0048643
Any process that activates, maintains or increases the rate of skeletal muscle tissue development.
1 Q32MD9 (/IMP)
Positive regulation of small GTPase mediated signal transduction GO:0051057
Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction.
1 Q32MD9 (/IMP)
Striated muscle cell differentiation GO:0051146
The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle.
1 Q32MD9 (/IGI)
Embryonic retina morphogenesis in camera-type eye GO:0060059
The process in which the anatomical structure of the retina is generated and organized in a camera-type eye during the embryonic life stage.
1 Q32MD9 (/IMP)
Positive regulation of neural precursor cell proliferation GO:2000179
Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation.
1 Q32MD9 (/IMP)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q4KMG0 (/TAS) Q6AZB0 (/TAS) Q9BWV1 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
2 Q32MD9 (/TAS) Q6AZB0 (/TAS)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9BWV1 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q6AZB0 (/ISO)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q6AZB0 (/ISA)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q32MD9 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 O35158 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 Q32MD9 (/ISO)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q6AZB0 (/IDA)
Growth cone GO:0030426
The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic.
1 Q6AZB0 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 Q6AZB0 (/IDA)
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
1 D4A0Z7 (/IDA)
Axonal growth cone GO:0044295
The migrating motile tip of a growing nerve cell axon.
1 Q6AZB0 (/ISO)