The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 2143: B- and T-lymphocyte attenuator
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 2 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q7TSA3 (/IPI) Q7Z6A9 (/IPI) |
|
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
|
1 | Q7TSA3 (/IGI) |
There are 6 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Immune response-regulating cell surface receptor signaling pathway GO:0002768
A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response.
|
1 | Q7TSA3 (/IMP) |
|
Cell surface receptor signaling pathway GO:0007166
A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
|
1 | Q7TSA3 (/IDA) |
|
Negative regulation of B cell proliferation GO:0030889
Any process that stops, prevents or reduces the rate or extent of B cell proliferation.
|
1 | Q7TSA3 (/IMP) |
|
T cell costimulation GO:0031295
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.
|
1 | Q7Z6A9 (/TAS) |
|
Negative regulation of T cell proliferation GO:0042130
Any process that stops, prevents or reduces the rate or extent of T cell proliferation.
|
1 | Q7TSA3 (/IMP) |
|
Negative regulation of alpha-beta T cell proliferation GO:0046642
Any process that stops, prevents, or reduces the frequency, rate or extent of alpha-beta T cell proliferation.
|
1 | Q7TSA3 (/IMP) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
2 | Q7TSA3 (/TAS) Q7Z6A9 (/TAS) |
|
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
|
1 | Q7TSA3 (/IDA) |
|
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
|
1 | Q7TSA3 (/IDA) |