The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1739: Ig gamma-2A chain C region

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 2 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Antigen binding GO:0003823
Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen.
6 A0A0A6YY53 (/IDA) F6TQW2 (/IDA) P01865 (/IDA) P01867 (/IDA) P01868 (/IDA) P01869 (/IDA)
Immunoglobulin receptor binding GO:0034987
Interacting selectively and non-covalently with one or more specific sites on an immunoglobulin receptor molecule.
4 A0A075B5P5 (/IPI) P01863 (/IPI) P01869 (/IPI) P03987 (/IPI)

There are 19 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Humoral immune response mediated by circulating immunoglobulin GO:0002455
An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus.
6 A0A0A6YY53 (/IDA) F6TQW2 (/IDA) P01865 (/IDA) P01867 (/IDA) P01868 (/IDA) P01869 (/IDA)
Immunoglobulin mediated immune response GO:0016064
An immune response mediated by immunoglobulins, whether cell-bound or in solution.
6 A0A0A6YY53 (/IDA) F6TQW2 (/IDA) P01865 (/IDA) P01867 (/IDA) P01868 (/IDA) P01869 (/IDA)
Positive regulation of type IIa hypersensitivity GO:0001798
Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response.
4 P01865 (/IDA) P01867 (/IDA) P01868 (/IDA) P01869 (/IDA)
Positive regulation of type I hypersensitivity GO:0001812
Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response.
4 P01865 (/IDA) P01867 (/IDA) P01868 (/IDA) P01869 (/IDA)
Phagocytosis, recognition GO:0006910
The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell.
4 P01865 (/IDA) P01867 (/IDA) P01868 (/IDA) P01869 (/IDA)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
4 P01865 (/IDA) P01867 (/IDA) P01868 (/IDA) P01869 (/IDA)
Complement activation, classical pathway GO:0006958
Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
4 P01865 (/IDA) P01867 (/IDA) P01868 (/IDA) P01869 (/IDA)
Antibacterial humoral response GO:0019731
An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster.
4 A0A0A6YY53 (/IDA) F6TQW2 (/IDA) P01868 (/IDA) P01869 (/IDA)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
4 A0A0A6YY53 (/IDA) F6TQW2 (/IDA) P01868 (/IDA) P01869 (/IDA)
Positive regulation of phagocytosis GO:0050766
Any process that activates or increases the frequency, rate or extent of phagocytosis.
4 P01865 (/IDA) P01867 (/IDA) P01868 (/IDA) P01869 (/IDA)
Positive regulation of immune response GO:0050778
Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
4 P01865 (/IDA) P01867 (/IDA) P01868 (/IDA) P01869 (/IDA)
Antibody-dependent cellular cytotoxicity GO:0001788
Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells.
3 P01865 (/IDA) P01868 (/IDA) P01869 (/IDA)
Endosome to lysosome transport GO:0008333
The directed movement of substances from endosomes to lysosomes.
1 P01865 (/IDA)
Response to bacterium GO:0009617
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.
1 P01863 (/IEP)
Antigen processing and presentation GO:0019882
The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex.
1 P01865 (/IDA)
Regulation of proteolysis GO:0030162
Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein.
1 P01865 (/IDA)
Early endosome to late endosome transport GO:0045022
The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs.
1 P01865 (/IDA)
Positive regulation of endocytosis GO:0045807
Any process that activates or increases the frequency, rate or extent of endocytosis.
1 P01865 (/IDA)
Positive regulation of B cell activation GO:0050871
Any process that activates or increases the frequency, rate or extent of B cell activation.
1 P01865 (/IDA)

There are 4 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
7 A0A075B5P5 (/IDA) A0A0A6YY53 (/IDA) A0A1Y7VJN6 (/IDA) F6TQW2 (/IDA) P01867 (/IDA) P01868 (/IDA) P01869 (/IDA)
Immunoglobulin complex, circulating GO:0042571
An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component.
6 A0A0A6YY53 (/IDA) F6TQW2 (/IDA) P01865 (/IDA) P01867 (/IDA) P01868 (/IDA) P01869 (/IDA)
External side of plasma membrane GO:0009897
The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.
2 P01868 (/IDA) P01869 (/IDA)
Multivesicular body GO:0005771
A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.
1 P01865 (/IDA)