The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Immunoglobulins
".
FunFam 1326: Interleukin 1 receptor type 2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Interleukin-1 receptor activity GO:0004908
Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
|
2 | P27931 (/IPI) P27931 (/IPI) |
|
Interleukin-1 binding GO:0019966
Interacting selectively and non-covalently with interleukin-1.
|
2 | P27931 (/IPI) P27931 (/IPI) |
|
Interleukin-1 receptor activity GO:0004908
Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response.
|
1 | P27930 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | P27930 (/IPI) |
There are 7 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of protein processing GO:0010955
Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage.
|
2 | P27931 (/IMP) P27931 (/IMP) |
|
Negative regulation of interleukin-1 alpha secretion GO:0050712
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell.
|
2 | P27931 (/IMP) P27931 (/IMP) |
|
Negative regulation of cytokine production involved in inflammatory response GO:1900016
Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
|
2 | P27931 (/IMP) P27931 (/IMP) |
|
Negative regulation of interleukin-1-mediated signaling pathway GO:2000660
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway.
|
2 | P27931 (/IPI) P27931 (/IPI) |
|
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
|
1 | P27930 (/TAS) |
|
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P27930 (/TAS) |
|
Interleukin-1-mediated signaling pathway GO:0070498
A series of molecular signals initiated by the binding of interleukin-1 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
1 | P27930 (/TAS) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | P27931 (/IDA) P27931 (/IDA) |
|
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
|
1 | P27930 (/TAS) |