The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1076: Triggering receptor expressed on myeloid cells 2

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 31 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
3 Q99NH8 (/IPI) Q9NZC2 (/IPI) Q9NZC2 (/IPI)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
2 Q9NZC2 (/IPI) Q9NZC2 (/IPI)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
High-density lipoprotein particle binding GO:0008035
Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Lipid binding GO:0008289
Interacting selectively and non-covalently with a lipid.
2 Q9NZC2 (/TAS) Q9NZC2 (/TAS)
Low-density lipoprotein particle binding GO:0030169
Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Apolipoprotein binding GO:0034185
Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.
2 Q9NZC2 (/IPI) Q9NZC2 (/IPI)
Apolipoprotein A-I binding GO:0034186
Interacting selectively and non-covalently with apolipoprotein A-I.
2 Q9NZC2 (/IPI) Q9NZC2 (/IPI)
Very-low-density lipoprotein particle binding GO:0034189
Interacting selectively and non-covalently with a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
2 Q9NZC2 (/IPI) Q9NZC2 (/IPI)
Lipoprotein particle binding GO:0071813
Interacting selectively and non-covalently with a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
2 Q9NZC2 (/IPI) Q9NZC2 (/IPI)
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Lipopolysaccharide binding GO:0001530
Interacting selectively and non-covalently with lipopolysaccharide.
1 Q99NH8 (/IDA)
Amyloid-beta binding GO:0001540
Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
1 Q99NH8 (/ISO)
Transmembrane signaling receptor activity GO:0004888
Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction.
1 Q99NH8 (/ISS)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 Q99NH8 (/ISO)
Phospholipid binding GO:0005543
Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester.
1 Q99NH8 (/ISS)
High-density lipoprotein particle binding GO:0008035
Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE.
1 Q99NH8 (/ISO)
Low-density lipoprotein particle binding GO:0030169
Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm.
1 Q99NH8 (/ISO)
Apolipoprotein binding GO:0034185
Interacting selectively and non-covalently with an apolipoprotein, the protein component of a lipoprotein complex.
1 Q99NH8 (/ISO)
Apolipoprotein A-I binding GO:0034186
Interacting selectively and non-covalently with apolipoprotein A-I.
1 Q99NH8 (/ISO)
Very-low-density lipoprotein particle binding GO:0034189
Interacting selectively and non-covalently with a very-low-density lipoprotein particle, a triglyceride-rich lipoprotein particle that is typically composed of APOB100, APOE and APOCs and has a density of about 1.006 g/ml and a diameter of between 20-80 nm.
1 Q99NH8 (/ISO)
Signaling receptor activity GO:0038023
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
1 Q99NH8 (/IMP)
Peptidoglycan binding GO:0042834
Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
1 Q99NH8 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q99NH8 (/ISO)
Lipoteichoic acid binding GO:0070891
Interacting selectively and non-covalently with lipoteichoic acid.
1 Q99NH8 (/IDA)
Lipoprotein particle binding GO:0071813
Interacting selectively and non-covalently with a lipoprotein particle. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids.
1 Q99NH8 (/ISO)
Scaffold protein binding GO:0097110
Interacting selectively and non-covalently with a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.
1 Q99NH8 (/ISO)
Protein tyrosine kinase binding GO:1990782
Interacting selectively and non-covalently with protein tyrosine kinase.
1 Q99NH8 (/IPI)

There are 115 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of phagocytosis, engulfment GO:0060100
Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
3 Q99NH8 (/IMP) Q9NZC2 (/IMP) Q9NZC2 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
3 Q99NH8 (/IMP) Q9NZC2 (/IMP) Q9NZC2 (/IMP)
Positive regulation of microglial cell activation GO:1903980
Any process that activates or increases the frequency, rate or extent of microglial cell activation.
3 Q99NH8 (/IMP) Q9NZC2 (/IMP) Q9NZC2 (/IMP)
Microglial cell activation GO:0001774
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of antigen processing and presentation of peptide antigen via MHC class II GO:0002588
Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Humoral immune response GO:0006959
An immune response mediated through a body fluid.
2 Q9NZC2 (/TAS) Q9NZC2 (/TAS)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of mitochondrion organization GO:0010822
Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
2 Q9NZC2 (/IMP) Q9NZC2 (/IMP)
Regulation of TOR signaling GO:0032006
Any process that modulates the frequency, rate or extent of TOR signaling.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Regulation of interleukin-6 production GO:0032675
Any process that modulates the frequency, rate, or extent of interleukin-6 production.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of macrophage fusion GO:0034241
Any process that activates or increases the frequency, rate or extent of macrophage fusion.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
2 Q9NZC2 (/TAS) Q9NZC2 (/TAS)
Astrocyte activation GO:0048143
A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
2 Q9NZC2 (/IMP) Q9NZC2 (/IMP)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
2 Q9NZC2 (/TAS) Q9NZC2 (/TAS)
Positive regulation of calcium-mediated signaling GO:0050850
Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Positive regulation of chemotaxis GO:0050921
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Regulation of resting membrane potential GO:0060075
Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Regulation of macrophage inflammatory protein 1 alpha production GO:0071640
Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Dendritic cell differentiation GO:0097028
The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Import into cell GO:0098657
The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Regulation of plasma membrane bounded cell projection organization GO:0120035
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections.
2 Q9NZC2 (/IGI) Q9NZC2 (/IGI)
Regulation of plasma membrane bounded cell projection organization GO:0120035
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of amyloid-beta clearance GO:1900223
Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of engulfment of apoptotic cell GO:1901076
Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
2 Q9NZC2 (/IMP) Q9NZC2 (/IMP)
Positive regulation of proteasomal protein catabolic process GO:1901800
Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of inward rectifier potassium channel activity GO:1901980
Any process that activates or increases the frequency, rate or extent of inward rectifier potassium channel activity.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Regulation of intracellular signal transduction GO:1902531
Any process that modulates the frequency, rate or extent of intracellular signal transduction.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Positive regulation of C-C chemokine receptor CCR7 signaling pathway GO:1903082
Any process that activates or increases the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Negative regulation of autophagic cell death GO:1904093
Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of microglial cell migration GO:1904141
Any process that activates or increases the frequency, rate or extent of microglial cell migration.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of CAMKK-AMPK signaling cascade GO:1905291
Any process that activates or increases the frequency, rate or extent of CAMKK-AMPK signaling cascade.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Positive regulation of CD40 signaling pathway GO:2000350
Any process that activates or increases the frequency, rate or extent of signaling via the CD40 signaling pathway.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Positive regulation of ATP biosynthetic process GO:2001171
Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
2 Q9NZC2 (/ISS) Q9NZC2 (/ISS)
Microglial cell activation GO:0001774
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 Q99NH8 (/IGI)
Microglial cell activation GO:0001774
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 Q99NH8 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 Q99NH8 (/IGI)
Microglial cell activation involved in immune response GO:0002282
The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response.
1 Q99NH8 (/IMP)
Positive regulation of antigen processing and presentation of peptide antigen via MHC class II GO:0002588
Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II.
1 Q99NH8 (/ISO)
Response to ischemia GO:0002931
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply.
1 Q99NH8 (/IMP)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
1 Q99NH8 (/IDA)
Phagocytosis, engulfment GO:0006911
The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
1 Q99NH8 (/IMP)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q99NH8 (/IGI)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q99NH8 (/IMP)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q99NH8 (/IGI)
Negative regulation of autophagy GO:0010507
Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm.
1 Q99NH8 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q99NH8 (/IGI)
Positive regulation of mitochondrion organization GO:0010822
Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion.
1 Q99NH8 (/IMP)
Osteoclast differentiation GO:0030316
The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.
1 Q99NH8 (/ISO)
Lipopolysaccharide-mediated signaling pathway GO:0031663
A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.
1 Q99NH8 (/IC)
Regulation of TOR signaling GO:0032006
Any process that modulates the frequency, rate or extent of TOR signaling.
1 Q99NH8 (/IMP)
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
1 Q99NH8 (/IGI)
Detection of lipopolysaccharide GO:0032497
The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
1 Q99NH8 (/IDA)
Detection of peptidoglycan GO:0032499
The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule.
1 Q99NH8 (/IDA)
Regulation of interleukin-6 production GO:0032675
Any process that modulates the frequency, rate, or extent of interleukin-6 production.
1 Q99NH8 (/IGI)
Negative regulation of interleukin-1 beta production GO:0032691
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.
1 Q99NH8 (/IMP)
Negative regulation of tumor necrosis factor production GO:0032720
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
1 Q99NH8 (/IMP)
Positive regulation of interleukin-10 production GO:0032733
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.
1 Q99NH8 (/IMP)
Positive regulation of macrophage fusion GO:0034241
Any process that activates or increases the frequency, rate or extent of macrophage fusion.
1 Q99NH8 (/IMP)
Defense response to bacterium GO:0042742
Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism.
1 Q99NH8 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 Q99NH8 (/IMP)
Apoptotic cell clearance GO:0043277
The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte.
1 Q99NH8 (/IMP)
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
1 Q99NH8 (/IC)
Regulation of innate immune response GO:0045088
Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection.
1 Q99NH8 (/IMP)
Positive regulation of osteoclast differentiation GO:0045672
Any process that activates or increases the frequency, rate or extent of osteoclast differentiation.
1 Q99NH8 (/IMP)
Astrocyte activation GO:0048143
A change in morphology and behavior of an astrocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.
1 Q99NH8 (/IGI)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
1 Q99NH8 (/ISO)
Regulation of peptidyl-tyrosine phosphorylation GO:0050730
Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 Q99NH8 (/IGI)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
1 Q99NH8 (/ISO)
Positive regulation of calcium-mediated signaling GO:0050850
Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling.
1 Q99NH8 (/ISO)
Positive regulation of chemotaxis GO:0050921
Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient.
1 Q99NH8 (/IGI)
Regulation of resting membrane potential GO:0060075
Any process that modulates the establishment or extent of a resting potential, the electrical charge across the plasma membrane, with the interior of the cell negative with respect to the exterior. The resting potential is the membrane potential of a cell that is not stimulated to be depolarized or hyperpolarized.
1 Q99NH8 (/IMP)
Positive regulation of phagocytosis, engulfment GO:0060100
Any process that activates or increases the frequency, rate or extent of the internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis.
1 Q99NH8 (/ISO)
Microglial cell proliferation GO:0061518
The expansion of a microglial cell population by cell division.
1 Q99NH8 (/IMP)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q99NH8 (/ISO)
Positive regulation of ERK1 and ERK2 cascade GO:0070374
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the ERK1 and ERK2 cascade.
1 Q99NH8 (/ISS)
Detection of lipoteichoic acid GO:0070392
The series of events in which a lipoteichoic acid stimulus is received by a cell and converted into a molecular signal; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
1 Q99NH8 (/IDA)
Cellular response to lipoteichoic acid GO:0071223
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoteichoic acid stimulus; lipoteichoic acid is a major component of the cell wall of gram-positive bacteria and typically consists of a chain of glycerol-phosphate repeating units linked to a glycolipid anchor.
1 Q99NH8 (/IDA)
Cellular response to peptidoglycan GO:0071224
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.
1 Q99NH8 (/IDA)
Regulation of macrophage inflammatory protein 1 alpha production GO:0071640
Any process that modulates the frequency, rate, or extent of production of macrophage inflammatory protein 1 alpha.
1 Q99NH8 (/IGI)
Dendritic cell differentiation GO:0097028
The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.
1 Q99NH8 (/ISO)
Amyloid-beta clearance GO:0097242
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.
1 Q99NH8 (/IMP)
Import into cell GO:0098657
The directed movement of some substance from outside of a cell into a cell. This may occur via transport across the plasma membrane or via endocytosis.
1 Q99NH8 (/IGI)
Regulation of plasma membrane bounded cell projection organization GO:0120035
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections.
1 Q99NH8 (/IMP)
Regulation of plasma membrane bounded cell projection organization GO:0120035
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of plasma membrane bounded cell projections.
1 Q99NH8 (/ISO)
Complement-mediated synapse pruning GO:0150062
Synaptic pruning mediated by complement system signalling.
1 Q99NH8 (/IMP)
Neuroinflammatory response GO:0150076
The immediate defensive reaction by neural vertebrate tissue to infection or injury caused by chemical or physical agents.
1 Q99NH8 (/IMP)
Positive regulation of neuroinflammatory response GO:0150078
Any process that activates or increases the frequency, rate or extent of neuroinflammatory response.
1 Q99NH8 (/IMP)
Positive regulation of amyloid-beta clearance GO:1900223
Any process that activates or increases the frequency, rate or extent of amyloid-beta clearance.
1 Q99NH8 (/IMP)
Positive regulation of engulfment of apoptotic cell GO:1901076
Any process that activates or increases the frequency, rate or extent of engulfment of apoptotic cell.
1 Q99NH8 (/ISO)
Positive regulation of NIK/NF-kappaB signaling GO:1901224
Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
1 Q99NH8 (/IMP)
Positive regulation of proteasomal protein catabolic process GO:1901800
Any process that activates or increases the frequency, rate or extent of proteasomal protein catabolic process.
1 Q99NH8 (/IMP)
Positive regulation of inward rectifier potassium channel activity GO:1901980
Any process that activates or increases the frequency, rate or extent of inward rectifier potassium channel activity.
1 Q99NH8 (/IMP)
Regulation of intracellular signal transduction GO:1902531
Any process that modulates the frequency, rate or extent of intracellular signal transduction.
1 Q99NH8 (/IGI)
Positive regulation of protein localization to plasma membrane GO:1903078
Any process that activates or increases the frequency, rate or extent of protein localization to plasma membrane.
1 Q99NH8 (/ISO)
Positive regulation of C-C chemokine receptor CCR7 signaling pathway GO:1903082
Any process that activates or increases the frequency, rate or extent of C-C chemokine receptor CCR7 signaling pathway.
1 Q99NH8 (/ISO)
Positive regulation of microglial cell activation GO:1903980
Any process that activates or increases the frequency, rate or extent of microglial cell activation.
1 Q99NH8 (/ISO)
Negative regulation of autophagic cell death GO:1904093
Any process that stops, prevents or reduces the frequency, rate or extent of autophagic cell death.
1 Q99NH8 (/IGI)
Positive regulation of microglial cell migration GO:1904141
Any process that activates or increases the frequency, rate or extent of microglial cell migration.
1 Q99NH8 (/IGI)
Positive regulation of microglial cell migration GO:1904141
Any process that activates or increases the frequency, rate or extent of microglial cell migration.
1 Q99NH8 (/IMP)
Cellular response to amyloid-beta GO:1904646
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus.
1 Q99NH8 (/IGI)
Positive regulation of CAMKK-AMPK signaling cascade GO:1905291
Any process that activates or increases the frequency, rate or extent of CAMKK-AMPK signaling cascade.
1 Q99NH8 (/IGI)
Positive regulation of CD40 signaling pathway GO:2000350
Any process that activates or increases the frequency, rate or extent of signaling via the CD40 signaling pathway.
1 Q99NH8 (/ISO)
Positive regulation of ATP biosynthetic process GO:2001171
Any process that activates or increases the frequency, rate or extent of ATP biosynthetic process.
1 Q99NH8 (/IMP)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q99NH8 (/IMP) Q9NZC2 (/IMP) Q9NZC2 (/IMP)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 Q9NZC2 (/TAS) Q9NZC2 (/TAS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q9NZC2 (/IDA) Q9NZC2 (/IDA)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
2 Q9NZC2 (/IMP) Q9NZC2 (/IMP)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q99NH8 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q99NH8 (/ISS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q99NH8 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q99NH8 (/ISO)
Intrinsic component of plasma membrane GO:0031226
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.
1 Q99NH8 (/ISO)