The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1062: OX-2 membrane glycoprotein

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O54901 (/IPI) P41217 (/IPI)
Protein binding involved in heterotypic cell-cell adhesion GO:0086080
Interacting selectively and non-covalently with any protein or protein complex contributing to the adhesion of two different types of cells.
1 P04218 (/IPI)
Protein binding involved in heterotypic cell-cell adhesion GO:0086080
Interacting selectively and non-covalently with any protein or protein complex contributing to the adhesion of two different types of cells.
1 O54901 (/ISO)
Protein binding involved in heterotypic cell-cell adhesion GO:0086080
Interacting selectively and non-covalently with any protein or protein complex contributing to the adhesion of two different types of cells.
1 P41217 (/ISS)
Glycosylated region protein binding GO:0140081
Interacting selectively and non-covalently with a glycosylated region of a protein.
1 P41217 (/TAS)

There are 44 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Heterotypic cell-cell adhesion GO:0034113
The attachment of a cell to a cell of a different type via adhesion molecules.
2 P04218 (/IGI) P41217 (/IGI)
Negative regulation of leukocyte activation GO:0002695
Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation.
1 P41217 (/TAS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 O54901 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P41217 (/ISS)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 P41217 (/IDA)
Negative regulation of NF-kappaB transcription factor activity GO:0032088
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
1 O54901 (/ISO)
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
1 P41217 (/IDA)
Positive regulation of CREB transcription factor activity GO:0032793
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.
1 O54901 (/ISO)
Heterotypic cell-cell adhesion GO:0034113
The attachment of a cell to a cell of a different type via adhesion molecules.
1 P04218 (/IPI)
Heterotypic cell-cell adhesion GO:0034113
The attachment of a cell to a cell of a different type via adhesion molecules.
1 O54901 (/ISO)
Heterotypic cell-cell adhesion GO:0034113
The attachment of a cell to a cell of a different type via adhesion molecules.
1 P41217 (/ISS)
Negative regulation of macrophage activation GO:0043031
Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.
1 O54901 (/IMP)
Negative regulation of macrophage activation GO:0043031
Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation.
1 P41217 (/ISS)
Regulation of immune response GO:0050776
Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus.
1 P41217 (/TAS)
Positive regulation of transforming growth factor beta production GO:0071636
Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta.
1 P41217 (/IGI)
Positive regulation of transforming growth factor beta production GO:0071636
Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta.
1 O54901 (/ISO)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 P04218 (/IGI)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 O54901 (/ISO)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 P41217 (/ISS)
Positive regulation of arginase activity GO:0150072
Any process that activates or increases the frequency, rate or extent of arginase activity.
1 P41217 (/IGI)
Positive regulation of arginase activity GO:0150072
Any process that activates or increases the frequency, rate or extent of arginase activity.
1 O54901 (/ISO)
Positive regulation of protein-glutamine gamma-glutamyltransferase activity GO:0150074
Any process that activates or increases the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity.
1 P41217 (/IGI)
Positive regulation of protein-glutamine gamma-glutamyltransferase activity GO:0150074
Any process that activates or increases the frequency, rate or extent of protein-glutamine gamma-glutamyltransferase activity.
1 O54901 (/ISO)
Regulation of neuroinflammatory response GO:0150077
Any process that modulates the frequency, rate or extent of neuroinflammatory response.
1 P04218 (/IGI)
Regulation of neuroinflammatory response GO:0150077
Any process that modulates the frequency, rate or extent of neuroinflammatory response.
1 O54901 (/ISO)
Regulation of neuroinflammatory response GO:0150077
Any process that modulates the frequency, rate or extent of neuroinflammatory response.
1 P41217 (/ISS)
Negative regulation of neuroinflammatory response GO:0150079
Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.
1 P04218 (/IGI)
Negative regulation of neuroinflammatory response GO:0150079
Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.
1 O54901 (/IMP)
Negative regulation of neuroinflammatory response GO:0150079
Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.
1 O54901 (/ISO)
Negative regulation of neuroinflammatory response GO:0150079
Any process that stops, prevents or reduces the frequency, rate or extent of neuroinflammatory response.
1 P41217 (/ISS)
Negative regulation of interleukin-6 secretion GO:1900165
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.
1 P04218 (/IGI)
Negative regulation of interleukin-6 secretion GO:1900165
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.
1 O54901 (/ISO)
Negative regulation of interleukin-6 secretion GO:1900165
Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-6 secretion.
1 P41217 (/ISS)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 P04218 (/IGI)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 O54901 (/ISO)
Negative regulation of neuron death GO:1901215
Any process that stops, prevents or reduces the frequency, rate or extent of neuron death.
1 P41217 (/ISS)
Negative regulation of matrix metallopeptidase secretion GO:1904465
Any process that stops, prevents or reduces the frequency, rate or extent of matrix metallopeptidase secretion.
1 P41217 (/IDA)
Negative regulation of matrix metallopeptidase secretion GO:1904465
Any process that stops, prevents or reduces the frequency, rate or extent of matrix metallopeptidase secretion.
1 O54901 (/ISO)
Negative regulation of macrophage migration GO:1905522
Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration.
1 P04218 (/IGI)
Negative regulation of macrophage migration GO:1905522
Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration.
1 O54901 (/ISO)
Negative regulation of macrophage migration GO:1905522
Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration.
1 P41217 (/ISS)
Negative regulation of T cell migration GO:2000405
Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration.
1 P04218 (/IGI)
Negative regulation of T cell migration GO:2000405
Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration.
1 O54901 (/ISO)
Negative regulation of T cell migration GO:2000405
Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration.
1 P41217 (/ISS)

There are 17 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
3 O54901 (/IDA) P04218 (/IDA) P41217 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
2 P04218 (/IDA) P41217 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 P41217 (/TAS)
Integral component of plasma membrane GO:0005887
The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 P41217 (/TAS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 O54901 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P41217 (/ISS)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
1 P41217 (/TAS)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 P41217 (/NAS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 P41217 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 O54901 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P04218 (/IDA)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 O54901 (/ISO)
Neuron projection GO:0043005
A prolongation or process extending from a nerve cell, e.g. an axon or dendrite.
1 P41217 (/ISS)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 O54901 (/ISO)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P41217 (/ISS)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 P41217 (/IDA)
Cell body GO:0044297
The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections.
1 O54901 (/ISO)