The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1045: Interleukin 6 receptor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P08887 (/IPI) P08887 (/IPI)
Enzyme binding GO:0019899
Interacting selectively and non-covalently with any enzyme.
2 P08887 (/IPI) P08887 (/IPI)
Interleukin-6 binding GO:0019981
Interacting selectively and non-covalently with interleukin-6.
2 P08887 (/IPI) P08887 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
2 P08887 (/IPI) P08887 (/IPI)
Ciliary neurotrophic factor binding GO:0070119
Interacting selectively and non-covalently with the cytokine ciliary neurotrophic factor.
2 P08887 (/IPI) P08887 (/IPI)

There are 23 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Hepatic immune response GO:0002384
An immune response taking place in the liver.
2 P08887 (/TAS) P08887 (/TAS)
Monocyte chemotaxis GO:0002548
The movement of a monocyte in response to an external stimulus.
2 P08887 (/IC) P08887 (/IC)
Positive regulation of leukocyte chemotaxis GO:0002690
Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis.
2 P08887 (/TAS) P08887 (/TAS)
Acute-phase response GO:0006953
An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals.
2 P08887 (/TAS) P08887 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P08887 (/IDA) P08887 (/IDA)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
2 P08887 (/IMP) P08887 (/IMP)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P08887 (/IDA) P08887 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P08887 (/TAS) P08887 (/TAS)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
2 P08887 (/IC) P08887 (/IC)
Endocrine pancreas development GO:0031018
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.
2 P08887 (/IMP) P08887 (/IMP)
Positive regulation of chemokine production GO:0032722
Any process that activates or increases the frequency, rate, or extent of chemokine production.
2 P08887 (/IDA) P08887 (/IDA)
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
2 P08887 (/IDA) P08887 (/IDA)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
2 P08887 (/IDA) P08887 (/IDA)
Positive regulation of tyrosine phosphorylation of STAT protein GO:0042531
Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein.
2 P08887 (/IMP) P08887 (/IMP)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
2 P08887 (/TAS) P08887 (/TAS)
Positive regulation of smooth muscle cell proliferation GO:0048661
Any process that activates or increases the rate or extent of smooth muscle cell proliferation.
2 P08887 (/IDA) P08887 (/IDA)
Positive regulation of peptidyl-tyrosine phosphorylation GO:0050731
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.
2 P08887 (/IDA) P08887 (/IDA)
Defense response to Gram-negative bacterium GO:0050829
Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism.
2 P08887 (/TAS) P08887 (/TAS)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P08887 (/IMP) P08887 (/IMP)
Interleukin-6-mediated signaling pathway GO:0070102
A series of molecular signals initiated by the binding of interleukin-6 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P08887 (/TAS) P08887 (/TAS)
Ciliary neurotrophic factor-mediated signaling pathway GO:0070120
A series of molecular signals initiated by the binding of a ciliary neurotrophic factor (CNTF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
2 P08887 (/IMP) P08887 (/IMP)
Positive regulation of glomerular mesangial cell proliferation GO:0072126
Any process that increases the frequency, rate or extent of glomerular mesangial cell proliferation.
2 P08887 (/IMP) P08887 (/IMP)
Extrinsic apoptotic signaling pathway GO:0097191
A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.
2 P08887 (/TAS) P08887 (/TAS)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P08887 (/IDA) P08887 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
2 P08887 (/TAS) P08887 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P08887 (/TAS) P08887 (/TAS)
Interleukin-6 receptor complex GO:0005896
A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130.
2 P08887 (/IDA) P08887 (/IDA)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 P08887 (/IDA) P08887 (/IDA)
Ciliary neurotrophic factor receptor complex GO:0070110
A protein complex that acts as a receptor for the cytokine ciliary neurotrophic factor (CNTF). In humans the receptor complex is a hexamer composed of two molecules each of CNTF and CNTFR and one molecule each of gp130 and LIFR.
2 P08887 (/IDA) P08887 (/IDA)