The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Immunoglobulins
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 103: Kirre like nephrin family adhesion molecule 3

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 O97174 (/IPI) Q08180 (/IPI) Q08180 (/IPI) Q6UWL6 (/IPI) Q6X936 (/IPI) Q7TSU7 (/IPI) Q7TSU7 (/IPI) Q80W68 (/IPI) Q8BR86 (/IPI) Q8IZU9 (/IPI)
(4 more)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
4 A4JYG2 (/IDA) Q6NY23 (/IDA) Q7TSU7 (/IDA) Q7TSU7 (/IDA)
Cell adhesion molecule binding GO:0050839
Interacting selectively and non-covalently with a cell adhesion molecule.
4 O97174 (/IPI) Q8MSN7 (/IPI) Q9N9Y9 (/IPI) Q9W4T9 (/IPI)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
3 A4JYG2 (/IPI) Q08180 (/IPI) Q08180 (/IPI)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
2 Q08180 (/IPI) Q08180 (/IPI)
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
1 Q96J84 (/IPI)
Myosin binding GO:0017022
Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments.
1 Q80W68 (/ISO)
PDZ domain binding GO:0030165
Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins.
1 Q8BR86 (/NAS)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q6UWL6 (/ISS)

There are 43 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
8 A0A0R4IT86 (/IMP) A0A2R8RKI9 (/IMP) A5JTW0 (/IMP) B0CM22 (/IMP) O97174 (/IMP) Q8MSN7 (/IMP) Q9N9Y9 (/IMP) Q9W4T9 (/IMP)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
6 O97174 (/IMP) Q08180 (/IMP) Q08180 (/IMP) Q8MSN7 (/IMP) Q9N9Y9 (/IMP) Q9W4T9 (/IMP)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
6 O97174 (/IGI) Q08180 (/IGI) Q08180 (/IGI) Q8MSN7 (/IGI) Q9N9Y9 (/IGI) Q9W4T9 (/IGI)
Myoblast fusion GO:0007520
A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
6 O97174 (/TAS) Q08180 (/TAS) Q08180 (/TAS) Q8MSN7 (/TAS) Q9N9Y9 (/TAS) Q9W4T9 (/TAS)
Regulation of striated muscle tissue development GO:0016202
Any process that modulates the frequency, rate or extent of striated muscle development.
6 O97174 (/IMP) Q08180 (/IMP) Q08180 (/IMP) Q8MSN7 (/IMP) Q9N9Y9 (/IMP) Q9W4T9 (/IMP)
Glomerular basement membrane development GO:0032836
The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.
6 A0A0R4IT86 (/IMP) A0A2R8RKI9 (/IMP) A5JTW0 (/IMP) B0CM22 (/IMP) B0V1H1 (/IMP) B3DHL7 (/IMP)
Pronephric duct development GO:0039022
The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney.
6 A0A0R4IT86 (/IMP) A0A2R8RKI9 (/IMP) A5JTW0 (/IMP) B0CM22 (/IMP) B0V1H1 (/IMP) B3DHL7 (/IMP)
Glomerular visceral epithelial cell development GO:0072015
The process whose specific outcome is the progression of a glomerular visceral epithelial cell over time, from its formation to the mature structure. A glomerular visceral epithelial cell is a specialized epithelial cell that contains \feet\ that interdigitate with the \feet\ of other glomerular epithelial cells.
6 A0A0R4IT86 (/IMP) A0A2R8RKI9 (/IMP) A5JTW0 (/IMP) B0CM22 (/IMP) B0V1H1 (/IMP) B3DHL7 (/IMP)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
4 O97174 (/IMP) Q8MSN7 (/IMP) Q9N9Y9 (/IMP) Q9W4T9 (/IMP)
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157
The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell.
4 O97174 (/IMP) Q8MSN7 (/IMP) Q9N9Y9 (/IMP) Q9W4T9 (/IMP)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
4 A0A0R4IT86 (/IMP) A0A2R8RKI9 (/IMP) A5JTW0 (/IMP) B0CM22 (/IMP)
Larval visceral muscle development GO:0007523
The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure.
4 O97174 (/IMP) Q8MSN7 (/IMP) Q9N9Y9 (/IMP) Q9W4T9 (/IMP)
Regulation of striated muscle tissue development GO:0016202
Any process that modulates the frequency, rate or extent of striated muscle development.
4 O97174 (/IGI) Q8MSN7 (/IGI) Q9N9Y9 (/IGI) Q9W4T9 (/IGI)
Filtration diaphragm assembly GO:0036058
The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph.
4 O97174 (/IMP) Q8MSN7 (/IMP) Q9N9Y9 (/IMP) Q9W4T9 (/IMP)
Nephrocyte diaphragm assembly GO:0036059
The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney.
4 O97174 (/IMP) Q8MSN7 (/IMP) Q9N9Y9 (/IMP) Q9W4T9 (/IMP)
Pronephric glomerulus development GO:0039021
The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.
4 A0A0R4IT86 (/IMP) A0A2R8RKI9 (/IMP) A5JTW0 (/IMP) B0CM22 (/IMP)
Garland nephrocyte differentiation GO:0061321
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a garland nephrocyte. A garland nephrocyte is an insect renal cell that filters hemolymph and forms a ring with other garland nephrocytes around the esophagus. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
4 O97174 (/IMP) Q8MSN7 (/IMP) Q9N9Y9 (/IMP) Q9W4T9 (/IMP)
Nephrocyte filtration GO:0097206
The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm.
4 O97174 (/IMP) Q8MSN7 (/IMP) Q9N9Y9 (/IMP) Q9W4T9 (/IMP)
Regulation of myoblast fusion GO:1901739
Any process that modulates the frequency, rate or extent of myoblast fusion.
4 O97174 (/IMP) Q8MSN7 (/IMP) Q9N9Y9 (/IMP) Q9W4T9 (/IMP)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
3 Q7TSU7 (/IGI) Q7TSU7 (/IGI) Q80W68 (/IGI)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
3 Q7TSU7 (/IGI) Q7TSU7 (/IGI) Q80W68 (/IGI)
Compound eye morphogenesis GO:0001745
The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster.
2 Q08180 (/IGI) Q08180 (/IGI)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
2 Q08180 (/TAS) Q08180 (/TAS)
Retinal cell programmed cell death GO:0046666
Programmed cell death that occurs in the developing retina.
2 Q08180 (/TAS) Q08180 (/TAS)
Compound eye retinal cell programmed cell death GO:0046667
Programmed cell death that occurs in the retina to remove excess cells between ommatidia, thus resulting in a hexagonal lattice, precise with respect to cell number and position surrounding each ommatidium.
2 Q08180 (/TAS) Q08180 (/TAS)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
2 Q08180 (/IMP) Q08180 (/IMP)
Neuron migration GO:0001764
The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature.
1 Q8BR86 (/IMP)
Inter-male aggressive behavior GO:0002121
Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious.
1 Q8BR86 (/IMP)
Cell adhesion GO:0007155
The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules.
1 Q6UWL6 (/NAS)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
1 Q8BR86 (/IDA)
Homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156
The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell.
1 Q8IZU9 (/ISS)
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
1 Q8BR86 (/IDA)
Synapse assembly GO:0007416
The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional).
1 Q8IZU9 (/ISS)
Excretion GO:0007588
The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds.
1 Q80W68 (/IMP)
Principal sensory nucleus of trigeminal nerve development GO:0021740
The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure.
1 Q8BR86 (/IMP)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 Q8BR86 (/IMP)
Hippocampus development GO:0021766
The progression of the hippocampus over time from its initial formation until its mature state.
1 Q8IZU9 (/ISS)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q8BR86 (/IDA)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q8IZU9 (/ISS)
Positive regulation of actin filament polymerization GO:0030838
Any process that activates or increases the frequency, rate or extent of actin polymerization.
1 Q80W68 (/IGI)
Neuron projection morphogenesis GO:0048812
The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
1 Q8BR86 (/IMP)
Glomerulus morphogenesis GO:0072102
The process in which the anatomical structures of the glomerulus are generated and organized. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.
1 Q8BR86 (/IMP)
Cell-cell adhesion GO:0098609
The attachment of one cell to another cell via adhesion molecules.
1 Q80W68 (/IDA)

There are 31 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
15 A0A0R4IT86 (/IDA) A0A2R8RKI9 (/IDA) A5JTW0 (/IDA) B0CM22 (/IDA) O97174 (/IDA) Q08180 (/IDA) Q08180 (/IDA) Q7TSU7 (/IDA) Q7TSU7 (/IDA) Q80W68 (/IDA)
(5 more)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
5 Q6X936 (/IDA) Q7TSU7 (/IDA) Q7TSU7 (/IDA) Q80W68 (/IDA) Q96J84 (/IDA)
Adherens junction GO:0005912
A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments.
4 O97174 (/IDA) Q8MSN7 (/IDA) Q9N9Y9 (/IDA) Q9W4T9 (/IDA)
Nephrocyte diaphragm GO:0005917
A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates.
4 O97174 (/IDA) Q8MSN7 (/IDA) Q9N9Y9 (/IDA) Q9W4T9 (/IDA)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 O97174 (/IDA) Q8MSN7 (/IDA) Q9N9Y9 (/IDA) Q9W4T9 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q08180 (/ISS) Q08180 (/ISS) Q6UWL6 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q6UWL6 (/TAS) Q8IZU9 (/TAS) Q96J84 (/TAS)
Cell-cell adherens junction GO:0005913
An adherens junction which connects a cell to another cell.
2 Q08180 (/IDA) Q08180 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
2 Q08180 (/TAS) Q08180 (/TAS)
Apical plasma membrane GO:0016324
The region of the plasma membrane located at the apical end of the cell.
2 Q08180 (/IDA) Q08180 (/IDA)
Slit diaphragm GO:0036057
A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.
2 Q7TSU7 (/IDA) Q7TSU7 (/IDA)
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
2 Q80W68 (/IDA) Q8BR86 (/IDA)
Apical part of cell GO:0045177
The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue.
2 Q08180 (/IDA) Q08180 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q8BR86 (/IDA)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 Q8IZU9 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 Q80W68 (/ISO)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q80W68 (/ISO)
Cell-cell junction GO:0005911
A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals.
1 Q6UWL6 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q8BR86 (/IDA)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q8IZU9 (/ISS)
Integral component of membrane GO:0016021
The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
1 Q6UWL6 (/NAS)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q8BR86 (/IDA)
Axon GO:0030424
The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter.
1 Q8IZU9 (/ISS)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q8BR86 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 Q8IZU9 (/ISS)
Cell projection membrane GO:0031253
The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.
1 Q6X936 (/IDA)
Cell projection membrane GO:0031253
The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection.
1 Q80W68 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q6X936 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 Q80W68 (/ISO)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q96J84 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
1 Q80W68 (/ISO)