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CATH Superfamily 2.60.200.20

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 233: Aprataxin

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Adenosine-5'-diphospho-5'-(DNA) diphosphatase. [EC: 3.1.11.7]
(1) Adenosine-5'-diphospho-5'-(DNA) + H(2)O = AMP + phospho-5'-(DNA). (2) Adenosine-5'-diphospho-5'-(ribonucleotide)-(DNA) + H(2)O = AMP + 5'-phospho-(ribonucleotide)-(DNA).
  • Aprataxin is a DNA-binding protein involved in different types of DNA break repair.
  • The enzyme acts (among other activities) on abortive DNA ligation intermediates that contain an adenylate covalently linked to the 5'-phosphate DNA terminus.
  • It also acts when the adenylate is covalently linked to the 5'-phosphate of a ribonucleotide linked to a DNA strand, which is the result of abortive ligase activty on products of EC 3.1.26.4, an enzyme that cleaves RNA-DNA hybrids on the 5' side of the ribonucleotide found in the 5'-RNA-DNA-3' junction.
  • Aprataxin binds the adenylate group to a histidine residue within the active site, followed by its hydrolysis from the nucleic acid and eventual release, leaving a 5'-phosphate terminus that can be efficiently rejoined.
  • The enzyme also possesses the activities of EC 3.1.11.8 and EC 3.1.12.2.
 1 P61798
DNA-3'-diphospho-5'-guanosine diphosphatase. [EC: 3.1.12.2]
(DNA)-3'-diphospho-5'-guanosine + H(2)O = (DNA)-3'-phosphate + GMP.
  • Aprataxin is a DNA-binding protein that catalyzes (among other activities) the 3' decapping of DNA-ppG (formed by EC 6.5.1.8).
  • The enzyme binds the guanylate group to a histidine residue at its active site, forming a covalent enzyme-nucleotide phosphate intermediate, followed by the hydrolysis of the guanylate from the nucleic acid and its eventual release.
  • The enzyme also possesses the activity of EC 3.1.11.7 and EC 3.1.11.8.
 1 P61798