The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cupin
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 4: Putative lysine-specific demethylase 3B

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 13 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q6PCM1 (/IPI) Q9Y4C1 (/IPI)
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
2 Q9VHC5 (/IMP) Q9Y4C1 (/IMP)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q6PCM1 (/IDA)
RNA polymerase II core promoter sequence-specific DNA binding GO:0000979
Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene.
1 Q6PCM1 (/IDA)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
1 Q6PCM1 (/IDA)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 Q9Y4C1 (/IMP)
Iron ion binding GO:0005506
Interacting selectively and non-covalently with iron (Fe) ions.
1 Q6PCM1 (/ISO)
Antioxidant activity GO:0016209
Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
1 M0RDF1 (/IDA)
Antioxidant activity GO:0016209
Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage.
1 Q6ZPY7 (/ISO)
Histone demethylase activity GO:0032452
Catalysis of the removal of a methyl group from a histone.
1 Q9VHC5 (/ISM)
Histone demethylase activity (H3-K9 specific) GO:0032454
Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein.
1 Q6PCM1 (/ISO)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
1 Q9Y4C1 (/IDA)
Androgen receptor binding GO:0050681
Interacting selectively and non-covalently with an androgen receptor.
1 Q6PCM1 (/ISO)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
4 A0A0G2K220 (/ISS) D3ZLJ9 (/ISS) Q63679 (/ISS) Q9Y4C1 (/ISS)
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
3 Q6PCM1 (/IMP) Q9VHC5 (/IMP) Q9Y4C1 (/IMP)
Response to hypoxia GO:0001666
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q63679 (/IEP)
Spermatogenesis GO:0007283
The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis.
1 Q6PCM1 (/IMP)
Spermatid nucleus elongation GO:0007290
The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation.
1 Q6PCM1 (/IMP)
Male gonad development GO:0008584
The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure.
1 Q63679 (/IEP)
Hormone-mediated signaling pathway GO:0009755
A series of molecular signals mediated by the detection of a hormone.
1 Q9Y4C1 (/IDA)
Hormone-mediated signaling pathway GO:0009755
A series of molecular signals mediated by the detection of a hormone.
1 Q6PCM1 (/ISO)
Regulation of gene expression GO:0010468
Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q6PCM1 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q63679 (/IMP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q6PCM1 (/ISO)
Histone demethylation GO:0016577
The modification of histones by removal of methyl groups.
1 Q9VHC5 (/ISM)
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
1 Q9Y4C1 (/IDA)
Androgen receptor signaling pathway GO:0030521
Any series of molecular signals generated as a consequence of an androgen binding to its receptor.
1 Q6PCM1 (/ISO)
Positive regulation of chromatin silencing GO:0031937
Any process that activates or increases the frequency, rate or extent of chromatin silencing.
1 Q9VHC5 (/IMP)
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
1 Q9Y4C1 (/IDA)
Histone H3-K9 demethylation GO:0033169
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.
1 Q6PCM1 (/ISO)
Histone H3-K9 dimethylation GO:0036123
The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone.
1 Q6PCM1 (/IDA)
Histone H3-K9 dimethylation GO:0036123
The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone.
1 Q6PCM1 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9Y4C1 (/IMP)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
1 Q6PCM1 (/ISO)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
1 Q6PCM1 (/IDA)
Formaldehyde biosynthetic process GO:0046293
The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde.
1 Q9Y4C1 (/IDA)
Formaldehyde biosynthetic process GO:0046293
The chemical reactions and pathways resulting in the formation of formaldehyde (methanal, H2C=O), the simplest aldehyde.
1 Q6PCM1 (/ISO)
Negative regulation of histone H3-K9 methylation GO:0051573
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 9 of histone H3.
1 Q6PCM1 (/IMP)
Response to cisplatin GO:0072718
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus.
1 M0RDF1 (/IMP)
Response to cisplatin GO:0072718
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cisplatin stimulus.
1 Q6ZPY7 (/ISO)
Positive regulation of cold-induced thermogenesis GO:0120162
Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
1 Q6PCM1 (/IMP)
Cellular response to leukemia inhibitory factor GO:1990830
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus.
1 Q6PCM1 (/IEP)
Regulation of stem cell population maintenance GO:2000036
Any process that modulates the frequency, rate or extent of stem cell population maintenance.
1 Q6PCM1 (/IGI)
Regulation of stem cell differentiation GO:2000736
Any process that modulates the frequency, rate or extent of stem cell differentiation.
1 Q6PCM1 (/IMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q6PCM1 (/IDA) Q9Y4C1 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q7LBC6 (/IDA) Q9Y4C1 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q6PCM1 (/ISO) Q6ZPY7 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q7LBC6 (/TAS) Q9Y4C1 (/TAS)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 Q9VHC5 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9VHC5 (/ISM)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q6PCM1 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q6PCM1 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
1 Q9Y4C1 (/HDA)