The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Clp1, DNA binding domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Protein CLP1 homolog 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 10 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Polydeoxyribonucleotide kinase activity GO:0051733
Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA.
45 A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS)
(35 more)
ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity GO:0051736
Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA.
45 A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS)
(35 more)
ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity GO:0051736
Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA.
19 P52874 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA)
(9 more)
ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity GO:0051736
Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA.
19 E7F3I6 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP)
(9 more)
ATP binding GO:0005524
Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
18 Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS)
(8 more)
Polydeoxyribonucleotide kinase activity GO:0051733
Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA.
18 Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA)
(8 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9SR06 (/IPI) Q9SR06 (/IPI)
Polydeoxyribonucleotide kinase activity GO:0051733
Catalysis of the reaction: NTP + 5'-dephospho-DNA = NDP + 5'-phospho-DNA.
2 Q99LI9 (/ISO) Q99LI9 (/ISO)
ATP-dependent polyribonucleotide 5'-hydroxyl-kinase activity GO:0051736
Catalysis of the reaction: ATP + 5'-dephospho-RNA = ADP + 5'-phospho-RNA.
2 Q99LI9 (/ISO) Q99LI9 (/ISO)
ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity GO:0046404
Catalysis of the reaction: ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.
1 Q10299 (/ISS)

There are 28 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
59 A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS)
(49 more)
Targeting of mRNA for destruction involved in RNA interference GO:0030423
The process in which small interfering RNAs target cognate mRNA molecules for degradation.
45 A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS)
(35 more)
SiRNA loading onto RISC involved in RNA interference GO:0035087
The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference.
45 A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS)
(35 more)
Cerebellar cortex development GO:0021695
The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
44 A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS)
(34 more)
Cerebellar cortex development GO:0021695
The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
20 Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP)
(10 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
18 Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS)
(8 more)
Termination of RNA polymerase II transcription GO:0006369
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.
18 Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS)
(8 more)
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
18 Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA)
(8 more)
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
18 Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP)
(8 more)
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
18 Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS)
(8 more)
Targeting of mRNA for destruction involved in RNA interference GO:0030423
The process in which small interfering RNAs target cognate mRNA molecules for degradation.
18 Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP) Q92989 (/IMP)
(8 more)
MRNA 3'-end processing GO:0031124
Any process involved in forming the mature 3' end of an mRNA molecule.
18 Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS)
(8 more)
SiRNA loading onto RISC involved in RNA interference GO:0035087
The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference.
18 Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA)
(8 more)
TRNA splicing, via endonucleolytic cleavage and ligation GO:0006388
Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons.
2 Q99LI9 (/ISO) Q99LI9 (/ISO)
MRNA processing GO:0006397
Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.
2 Q9SR06 (/IMP) Q9SR06 (/IMP)
Flower development GO:0009908
The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem.
2 Q9SR06 (/IMP) Q9SR06 (/IMP)
Vegetative to reproductive phase transition of meristem GO:0010228
The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence.
2 Q9SR06 (/IMP) Q9SR06 (/IMP)
Cerebellar cortex development GO:0021695
The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function.
2 Q99LI9 (/ISO) Q99LI9 (/ISO)
Targeting of mRNA for destruction involved in RNA interference GO:0030423
The process in which small interfering RNAs target cognate mRNA molecules for degradation.
2 Q99LI9 (/ISO) Q99LI9 (/ISO)
SiRNA loading onto RISC involved in RNA interference GO:0035087
The transfer of small interfering RNA molecules (siRNAs) from the Dicer family of enzymes that cleave the double-stranded RNA, onto the nuclease-containing RNA-initiated silencing complex (RISC), in the context of RNA interference.
2 Q99LI9 (/ISO) Q99LI9 (/ISO)
Phyllome development GO:0048827
The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants.
2 Q9SR06 (/IMP) Q9SR06 (/IMP)
MRNA polyadenylation GO:0006378
The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript.
1 Q10299 (/ISO)
MRNA cleavage GO:0006379
Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.
1 Q10299 (/ISO)
Brain development GO:0007420
The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.).
1 E7F3I6 (/IMP)
Spinal cord motor neuron differentiation GO:0021522
The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate.
1 E7F3I6 (/IMP)
Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
1 Q7K284 (/IGI)
Regulation of RNA splicing GO:0043484
Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA.
1 Q7K284 (/IMP)
Nucleotide phosphorylation GO:0046939
The process of introducing one or more phosphate groups into a nucleotide to produce a phosphorylated nucleoside.
1 P52874 (/IDA)

There are 14 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
TRNA-intron endonuclease complex GO:0000214
A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
58 A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS) A2VE01 (/ISS)
(48 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
23 E9PL17 (/IDA) E9PL17 (/IDA) E9PL17 (/IDA) E9PL17 (/IDA) E9PL17 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA)
(13 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
23 E9PL17 (/IDA) E9PL17 (/IDA) E9PL17 (/IDA) E9PL17 (/IDA) E9PL17 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA)
(13 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
20 Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA)
(10 more)
TRNA-intron endonuclease complex GO:0000214
A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
18 Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA) Q92989 (/IDA)
(8 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
18 Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS) Q92989 (/TAS)
(8 more)
TRNA-intron endonuclease complex GO:0000214
A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron.
2 Q99LI9 (/ISO) Q99LI9 (/ISO)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 Q99LI9 (/ISO) Q99LI9 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
2 Q99LI9 (/ISO) Q99LI9 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 Q99LI9 (/ISO) Q99LI9 (/ISO)
MRNA cleavage factor complex GO:0005849
Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules.
2 Q9SR06 (/IPI) Q9SR06 (/IPI)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q10299 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q10299 (/HDA)
MRNA cleavage factor complex GO:0005849
Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules.
1 Q10299 (/ISO)