The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Jelly Rolls
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 88: Guanine nucleotide exchange factor

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
8 B7Z025 (/IDA) B7Z026 (/IDA) G5ECB8 (/IDA) G5ECE2 (/IDA) G5EDB9 (/IDA) G5EEE0 (/IDA) Q95V18 (/IDA) Q9VMF3 (/IDA)
Ras GTPase binding GO:0017016
Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases.
4 B7Z025 (/IPI) B7Z026 (/IPI) Q95V18 (/IPI) Q9VMF3 (/IPI)
Rap guanyl-nucleotide exchange factor activity GO:0017034
Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
4 B7Z025 (/ISS) B7Z026 (/ISS) Q95V18 (/ISS) Q9VMF3 (/ISS)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
1 Q95V18 (/TAS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
1 G5EDB9 (/IPI)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
MAPK cascade GO:0000165
An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
4 B7Z025 (/IGI) B7Z026 (/IGI) Q95V18 (/IGI) Q9VMF3 (/IGI)
Substrate-dependent cell migration, cell extension GO:0006930
The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell.
4 B7Z025 (/IMP) B7Z026 (/IMP) Q95V18 (/IMP) Q9VMF3 (/IMP)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
4 B7Z025 (/IGI) B7Z026 (/IGI) Q95V18 (/IGI) Q9VMF3 (/IGI)
Dorsal closure GO:0007391
The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally.
4 B7Z025 (/IMP) B7Z026 (/IMP) Q95V18 (/IMP) Q9VMF3 (/IMP)
Imaginal disc-derived wing morphogenesis GO:0007476
The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying.
4 B7Z025 (/IMP) B7Z026 (/IMP) Q95V18 (/IMP) Q9VMF3 (/IMP)
Imaginal disc-derived male genitalia development GO:0007485
The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster.
4 B7Z025 (/IMP) B7Z026 (/IMP) Q95V18 (/IMP) Q9VMF3 (/IMP)
Epidermis development GO:0008544
The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.
4 G5ECB8 (/IMP) G5ECE2 (/IMP) G5EDB9 (/IMP) G5EEE0 (/IMP)
Regulation of embryonic cell shape GO:0016476
Any process that modulates the surface configuration of an embryonic cell.
4 B7Z025 (/IMP) B7Z026 (/IMP) Q95V18 (/IMP) Q9VMF3 (/IMP)
Molting cycle, collagen and cuticulin-based cuticle GO:0018996
The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans.
4 G5ECB8 (/IMP) G5ECE2 (/IMP) G5EDB9 (/IMP) G5EEE0 (/IMP)
Germ-line stem cell population maintenance GO:0030718
Any process by which an organism or tissue maintains a population of germ-line stem cells.
4 B7Z025 (/IMP) B7Z026 (/IMP) Q95V18 (/IMP) Q9VMF3 (/IMP)
Adherens junction assembly GO:0034333
The aggregation, arrangement and bonding together of a set of components to form an adherens junction. An adherens junction is a cell junction at which the cytoplasmic face of the plasma membrane is attached to actin filaments.
4 B7Z025 (/IGI) B7Z026 (/IGI) Q95V18 (/IGI) Q9VMF3 (/IGI)
Hemocyte migration GO:0035099
The directed movement of a hemocyte within the embryo. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen. In Drosophila, embryonic hemocytes originate from the head mesoderm as a cluster of cells. The cluster splits into two and one group of cells crosses the amnioserosa. Both populations then spread toward the middle of the embryo and then disperse evenly throughout the embryo.
4 B7Z025 (/IMP) B7Z026 (/IMP) Q95V18 (/IMP) Q9VMF3 (/IMP)
Collagen and cuticulin-based cuticle development GO:0040002
Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans.
4 G5ECB8 (/IMP) G5ECE2 (/IMP) G5EDB9 (/IMP) G5EEE0 (/IMP)
Positive regulation of GTPase activity GO:0043547
Any process that activates or increases the activity of a GTPase.
4 B7Z025 (/ISS) B7Z026 (/ISS) Q95V18 (/ISS) Q9VMF3 (/ISS)
Regulation of compound eye photoreceptor development GO:0045314
Any process that modulates the frequency, rate or extent of compound eye photoreceptor development.
4 B7Z025 (/IMP) B7Z026 (/IMP) Q95V18 (/IMP) Q9VMF3 (/IMP)
Oogenesis GO:0048477
The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
4 B7Z025 (/IMP) B7Z026 (/IMP) Q95V18 (/IMP) Q9VMF3 (/IMP)
Compound eye development GO:0048749
The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye.
4 B7Z025 (/IMP) B7Z026 (/IMP) Q95V18 (/IMP) Q9VMF3 (/IMP)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Apicolateral plasma membrane GO:0016327
The apical end of the lateral plasma membrane of epithelial cells.
4 B7Z025 (/IDA) B7Z026 (/IDA) Q95V18 (/IDA) Q9VMF3 (/IDA)
Collagen and cuticulin-based cuticle extracellular matrix GO:0060102
A collagen and cuticulin-based noncellular, multilayered structure that is synthesized by an underlying ectodermal (hypodermal) cell layer. The cuticle serves essential functions in body morphology, locomotion, and environmental protection. An example of this component is found in Caenorhabditis elegans.
4 G5ECB8 (/IDA) G5ECE2 (/IDA) G5EDB9 (/IDA) G5EEE0 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q95V18 (/TAS)