The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Jelly Rolls
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 3: Crp/Fnr family transcriptional regulator

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA binding GO:0003677
Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
16 P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) Q5SID7 (/IDA)
(6 more)
CAMP binding GO:0030552
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
16 P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) Q5SID7 (/IDA)
(6 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
11 A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA)
(1 more)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
11 A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP)
(1 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
11 A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA)
(1 more)
DNA-binding transcription activator activity GO:0001216
Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase.
11 A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP)
(1 more)
DNA-binding transcription factor activity GO:0003700
A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
10 P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) Q5SID7 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
9 P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI) P9WMH3 (/IPI)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
6 Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
6 Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
6 Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP)
DNA-binding transcription repressor activity GO:0001217
Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase.
6 Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 Q5SID7 (/IDA)
Sequence-specific DNA binding GO:0043565
Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
1 Q5SID7 (/IDA)
Transcription regulatory region DNA binding GO:0044212
Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors.
1 Q5SID7 (/IDA)

There are 6 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Regulation of transcription, DNA-templated GO:0006355
Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
15 P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) Q79VI7 (/IDA)
(5 more)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
10 P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) Q5SID7 (/IDA)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
9 P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA) P9WMH3 (/IDA)
Regulation of glyoxylate cycle GO:2000874
Any process that modulates the frequency, rate or extent of glyoxylate cycle.
6 Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
5 A0R5H1 (/EXP) A0R5H1 (/EXP) A0R5H1 (/EXP) A0R5H1 (/EXP) A0R5H1 (/EXP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 Q5SID7 (/IMP)

There are 5 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
11 A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) A0R5H1 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA) Q79VI7 (/IDA)
(1 more)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
11 A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) A0R5H1 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP) Q79VI7 (/IMP)
(1 more)
Cell wall GO:0005618
The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins.
9 P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
9 P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA) P9WMH3 (/HDA)
Protein-DNA complex GO:0032993
A macromolecular complex containing both protein and DNA molecules.
6 Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI) Q79VI7 (/IPI)