The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Jelly Rolls
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 27: Protein kinase cAMP-dependent type II regulatory s...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 24 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 A9C3T0 (/IPI) C1PIG4 (/IPI) P00515 (/IPI) P12367 (/IPI) P12368 (/IPI) P12369 (/IPI) P13861 (/IPI) P13861 (/IPI) P31322 (/IPI) P31323 (/IPI)
(4 more)
CAMP-dependent protein kinase regulator activity GO:0008603
Modulation of the activity of the enzyme cAMP-dependent protein kinase.
7 P12368 (/IDA) P12369 (/IDA) P13861 (/IDA) P13861 (/IDA) P31323 (/IDA) P31323 (/IDA) P31324 (/IDA)
CAMP-dependent protein kinase inhibitor activity GO:0004862
Stops, prevents or reduces the activity of a cAMP-dependent protein kinase.
4 P13861 (/IDA) P13861 (/IDA) P31323 (/IDA) P31323 (/IDA)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
4 P13861 (/IDA) P13861 (/IDA) P31323 (/IDA) P31323 (/IDA)
Protein kinase A catalytic subunit binding GO:0034236
Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A.
4 P13861 (/IPI) P13861 (/IPI) P31323 (/IPI) P31323 (/IPI)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
3 P12368 (/IPI) P13861 (/IPI) P13861 (/IPI)
CAMP-dependent protein kinase inhibitor activity GO:0004862
Stops, prevents or reduces the activity of a cAMP-dependent protein kinase.
2 P12367 (/ISO) P31324 (/ISO)
CAMP-dependent protein kinase regulator activity GO:0008603
Modulation of the activity of the enzyme cAMP-dependent protein kinase.
2 P12367 (/ISO) P31324 (/ISO)
CAMP-dependent protein kinase regulator activity GO:0008603
Modulation of the activity of the enzyme cAMP-dependent protein kinase.
2 P13861 (/NAS) P13861 (/NAS)
CAMP-dependent protein kinase regulator activity GO:0008603
Modulation of the activity of the enzyme cAMP-dependent protein kinase.
2 P31323 (/TAS) P31323 (/TAS)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 P12368 (/IDA) P12369 (/IDA)
Protein domain specific binding GO:0019904
Interacting selectively and non-covalently with a specific domain of a protein.
2 P12367 (/ISO) P31324 (/ISO)
CAMP binding GO:0030552
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
2 P12368 (/IDA) P12369 (/IDA)
CAMP binding GO:0030552
Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate).
2 P12367 (/ISO) P31324 (/ISO)
Ubiquitin protein ligase binding GO:0031625
Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins.
2 P12367 (/ISO) P31324 (/ISO)
Protein kinase A catalytic subunit binding GO:0034236
Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A.
2 P12368 (/IC) P12369 (/IC)
Protein kinase A catalytic subunit binding GO:0034236
Interacting selectively and non-covalently with one or both of the catalytic subunits of protein kinase A.
2 P12367 (/ISO) P31324 (/ISO)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 P31324 (/IPI)
Beta-2 adrenergic receptor binding GO:0031698
Interacting selectively and non-covalently with a beta-2 adrenergic receptor.
1 P12368 (/IPI)
Beta-2 adrenergic receptor binding GO:0031698
Interacting selectively and non-covalently with a beta-2 adrenergic receptor.
1 P12367 (/ISO)
Small molecule binding GO:0036094
Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule.
1 P12368 (/IDA)
Small molecule binding GO:0036094
Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule.
1 P12367 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P12368 (/IDA)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
1 P12367 (/ISO)

There are 22 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Renal water homeostasis GO:0003091
Renal process involved in the maintenance of an internal steady state of water in the body.
4 P13861 (/TAS) P13861 (/TAS) P31323 (/TAS) P31323 (/TAS)
Blood coagulation GO:0007596
The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers.
4 P13861 (/TAS) P13861 (/TAS) P31323 (/TAS) P31323 (/TAS)
Activation of protein kinase A activity GO:0034199
Any process that initiates the activity of the inactive enzyme protein kinase A.
4 P13861 (/TAS) P13861 (/TAS) P31323 (/TAS) P31323 (/TAS)
Intracellular signal transduction GO:0035556
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
4 P13861 (/TAS) P13861 (/TAS) P31323 (/TAS) P31323 (/TAS)
Cellular response to glucagon stimulus GO:0071377
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucagon stimulus.
4 P13861 (/TAS) P13861 (/TAS) P31323 (/TAS) P31323 (/TAS)
Negative regulation of cAMP-dependent protein kinase activity GO:2000480
Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.
4 P13861 (/IDA) P13861 (/IDA) P31323 (/IDA) P31323 (/IDA)
G2/M transition of mitotic cell cycle GO:0000086
The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex.
2 P31323 (/TAS) P31323 (/TAS)
Regulation of G2/M transition of mitotic cell cycle GO:0010389
Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
2 P31323 (/TAS) P31323 (/TAS)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
2 P12368 (/IDA) P12369 (/IDA)
Regulation of protein kinase activity GO:0045859
Any process that modulates the frequency, rate or extent of protein kinase activity.
2 P12367 (/ISO) P31324 (/ISO)
Modulation of chemical synaptic transmission GO:0050804
Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission.
2 P12367 (/IMP) P31324 (/IMP)
Response to clozapine GO:0097338
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus.
2 P12368 (/IEP) P12369 (/IEP)
Ciliary basal body-plasma membrane docking GO:0097711
The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.
2 P31323 (/TAS) P31323 (/TAS)
Negative regulation of cAMP-dependent protein kinase activity GO:2000480
Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.
2 P12367 (/ISO) P31324 (/ISO)
Fatty acid metabolic process GO:0006631
The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
1 P31324 (/IMP)
Learning GO:0007612
Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience.
1 P31324 (/IMP)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P12368 (/IDA)
Protein heterooligomerization GO:0051291
The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
1 P12367 (/ISO)
Response to antipsychotic drug GO:0097332
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antipsychotic drug stimulus. Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.
1 P12369 (/IEP)
Regulation of meiotic cell cycle process involved in oocyte maturation GO:1903538
Any process that modulates the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
1 C1PIG4 (/IMP)
Positive regulation of meiotic cell cycle process involved in oocyte maturation GO:1904146
Any process that activates or increases the frequency, rate or extent of meiotic cell cycle process involved in oocyte maturation.
1 C1PIG4 (/IMP)
Negative regulation of cAMP-dependent protein kinase activity GO:2000480
Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity.
1 C1PIG4 (/IMP)

There are 46 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
6 P12368 (/IDA) P12369 (/IDA) P13861 (/IDA) P13861 (/IDA) P31323 (/IDA) P31323 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
5 P12367 (/TAS) P13861 (/TAS) P13861 (/TAS) P31323 (/TAS) P31323 (/TAS)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
4 P13861 (/IDA) P13861 (/IDA) P31323 (/IDA) P31323 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
4 P13861 (/IDA) P13861 (/IDA) P31323 (/IDA) P31323 (/IDA)
CAMP-dependent protein kinase complex GO:0005952
An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.
4 P12368 (/IDA) P12369 (/IDA) P13861 (/IDA) P13861 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 P13861 (/HDA) P13861 (/HDA) P31323 (/HDA) P31323 (/HDA)
Ciliary base GO:0097546
Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
4 P13861 (/TAS) P13861 (/TAS) P31323 (/TAS) P31323 (/TAS)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
3 P12368 (/IDA) P13861 (/IDA) P13861 (/IDA)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
3 P12369 (/ISS) P31323 (/ISS) P31323 (/ISS)
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
3 P12369 (/ISS) P31323 (/ISS) P31323 (/ISS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P12367 (/ISO) P31324 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 P13861 (/TAS) P13861 (/TAS)
Centrosome GO:0005813
A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle.
2 P12367 (/ISO) P31324 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P12367 (/ISO) P31324 (/ISO)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 P13861 (/TAS) P13861 (/TAS)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
2 P13861 (/HDA) P13861 (/HDA)
CAMP-dependent protein kinase complex GO:0005952
An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer.
2 P12367 (/ISO) P31324 (/ISO)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P13861 (/HDA) P13861 (/HDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 P13861 (/TAS) P13861 (/TAS)
Nucleotide-activated protein kinase complex GO:0031588
A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
2 P13861 (/IDA) P13861 (/IDA)
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
2 P13861 (/IDA) P13861 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 P12368 (/IDA) P12369 (/IDA)
Perinuclear region of cytoplasm GO:0048471
Cytoplasm situated near, or occurring around, the nucleus.
2 P12367 (/ISO) P31324 (/ISO)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
2 P12369 (/IDA) P31324 (/IDA)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
2 P12367 (/IMP) P31324 (/IMP)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 C1PIG4 (/IMP)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 P12368 (/IDA)
T-tubule GO:0030315
Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane.
1 P12367 (/ISO)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P12369 (/IDA)
Dendrite GO:0030425
A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body.
1 P31324 (/ISO)
Nucleotide-activated protein kinase complex GO:0031588
A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).
1 P12367 (/ISO)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
1 P12367 (/ISO)
Germinal vesicle GO:0042585
The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity.
1 C1PIG4 (/IMP)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P12369 (/IDA)
Neuronal cell body GO:0043025
The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
1 P31324 (/ISO)
Dendritic spine GO:0043197
A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \thin\, \stubby\, \mushroom\, and \branched\, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity.
1 P31324 (/IDA)
Dendritic shaft GO:0043198
Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines.
1 P31324 (/IDA)
Plasma membrane raft GO:0044853
A membrane raft that is part of the plasma membrane.
1 P12367 (/ISO)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 P12369 (/IDA)
Membrane raft GO:0045121
Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions.
1 P31324 (/ISO)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 P12367 (/EXP)
Synapse GO:0045202
The junction between a nerve fiber of one neuron and another neuron, muscle fiber or glial cell. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
1 P12367 (/IDA)
Ciliary base GO:0097546
Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.
1 P31324 (/IDA)
Postsynapse GO:0098794
The part of a synapse that is part of the post-synaptic cell.
1 P31324 (/ISO)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P12367 (/EXP)
Glutamatergic synapse GO:0098978
A synapse that uses glutamate as a neurotransmitter.
1 P12367 (/IDA)