The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Acid Proteases
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 48: Napsin A aspartic peptidase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2 O09043 (/IMP) O09043 (/IMP)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
2 O09043 (/ISO) O09043 (/ISO)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 O09043 (/IPI) O09043 (/IPI)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
2 O09043 (/ISO) O09043 (/ISO)
Endopeptidase activity GO:0004175
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
1 O96009 (/IDA)
Aspartic-type endopeptidase activity GO:0004190
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
1 O96009 (/NAS)
Peptidase activity GO:0008233
Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
1 O96009 (/IDA)

There are 9 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Membrane protein proteolysis GO:0033619
The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Surfactant homeostasis GO:0043129
Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Membrane protein proteolysis GO:0033619
The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
2 O09043 (/IMP) O09043 (/IMP)
Membrane protein proteolysis GO:0033619
The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
2 O09043 (/ISO) O09043 (/ISO)
Surfactant homeostasis GO:0043129
Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.
2 O09043 (/ISO) O09043 (/ISO)
Proteolysis GO:0006508
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
1 O96009 (/NAS)
Membrane protein proteolysis GO:0033619
The proteolytic cleavage of a transmembrane protein leading to the release of its intracellular or ecto-domains.
1 O96009 (/IDA)
Surfactant homeostasis GO:0043129
Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli.
1 O96009 (/IDA)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
1 O96009 (/TAS)

There are 11 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Alveolar lamellar body GO:0097208
A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
12 E1BJW6 (/ISS) F1PWW2 (/ISS) F1RH37 (/ISS) F6TB54 (/ISS) F6ZTE4 (/ISS) F7EYE2 (/ISS) G1M3R7 (/ISS) G1R0R7 (/ISS) G3QK89 (/ISS) G7PYE3 (/ISS)
(2 more)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
3 O09043 (/IDA) O09043 (/IDA) O96009 (/IDA)
Alveolar lamellar body GO:0097208
A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
3 O09043 (/IDA) O09043 (/IDA) O96009 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 O09043 (/ISO) O09043 (/ISO)
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
2 O09043 (/ISO) O09043 (/ISO)
Alveolar lamellar body GO:0097208
A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.
2 O09043 (/ISO) O09043 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 O96009 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 O96009 (/HDA)
Multivesicular body lumen GO:0097486
The volume enclosed by the outermost membrane of a multivesicular body.
1 O96009 (/TAS)