The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 19: C-C motif chemokine 27

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
10 Q9NRJ3 (/IPI) Q9NRJ3 (/IPI) Q9NRJ3 (/IPI) Q9NRJ3 (/IPI) Q9Y4X3 (/IPI) Q9Y4X3 (/IPI) Q9Y4X3 (/IPI) Q9Y4X3 (/IPI) Q9Y4X3 (/IPI) Q9Z1X0 (/IPI)
Chemokine activity GO:0008009
The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
9 Q9NRJ3 (/TAS) Q9NRJ3 (/TAS) Q9NRJ3 (/TAS) Q9NRJ3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS)
CCR3 chemokine receptor binding GO:0031728
Interacting selectively and non-covalently with a CCR3 chemokine receptor.
5 Q9Y4X3 (/IPI) Q9Y4X3 (/IPI) Q9Y4X3 (/IPI) Q9Y4X3 (/IPI) Q9Y4X3 (/IPI)
Chemokine activity GO:0008009
The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
4 Q9NRJ3 (/IDA) Q9NRJ3 (/IDA) Q9NRJ3 (/IDA) Q9NRJ3 (/IDA)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
1 Q9Z1X0 (/IDA)
Chemokine activity GO:0008009
The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
1 Q9JIL2 (/ISO)
Chemokine activity GO:0008009
The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.
1 Q9JIL2 (/ISS)

There are 13 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chemotaxis GO:0006935
The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
9 Q9NRJ3 (/TAS) Q9NRJ3 (/TAS) Q9NRJ3 (/TAS) Q9NRJ3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS)
G protein-coupled receptor signaling pathway GO:0007186
A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576).
9 Q9NRJ3 (/TAS) Q9NRJ3 (/TAS) Q9NRJ3 (/TAS) Q9NRJ3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS)
Immune response GO:0006955
Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat.
5 Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS)
Cell-cell signaling GO:0007267
Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions.
5 Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS)
Positive regulation of cell-matrix adhesion GO:0001954
Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
4 Q9NRJ3 (/IDA) Q9NRJ3 (/IDA) Q9NRJ3 (/IDA) Q9NRJ3 (/IDA)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
4 Q9NRJ3 (/IDA) Q9NRJ3 (/IDA) Q9NRJ3 (/IDA) Q9NRJ3 (/IDA)
Negative regulation of leukocyte tethering or rolling GO:1903237
Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling.
4 Q9NRJ3 (/IDA) Q9NRJ3 (/IDA) Q9NRJ3 (/IDA) Q9NRJ3 (/IDA)
Response to nutrient GO:0007584
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.
3 A0A0G2JTM5 (/IEP) G3V896 (/IEP) Q91Y39 (/IEP)
Positive regulation of cell-matrix adhesion GO:0001954
Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix.
1 Q9JIL2 (/ISO)
Positive regulation of cytosolic calcium ion concentration GO:0007204
Any process that increases the concentration of calcium ions in the cytosol.
1 Q9JIL2 (/IDA)
Cell chemotaxis GO:0060326
The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).
1 Q9JIL2 (/ISO)
Negative regulation of leukocyte tethering or rolling GO:1903237
Any process that stops, prevents or reduces the frequency, rate or extent of leukocyte tethering or rolling.
1 Q9JIL2 (/ISO)
Positive regulation of actin cytoskeleton reorganization GO:2000251
Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization.
1 Q9Z1X0 (/IDA)

There are 2 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
9 Q9NRJ3 (/TAS) Q9NRJ3 (/TAS) Q9NRJ3 (/TAS) Q9NRJ3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS) Q9Y4X3 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
4 Q9NRJ3 (/HDA) Q9NRJ3 (/HDA) Q9NRJ3 (/HDA) Q9NRJ3 (/HDA)