The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Histone-lysine N-methyltransferase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 16 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
6 Q32PH7 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q9H5I1 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 Q9EQQ0 (/IPI) Q9H5I1 (/IPI)
Transcription regulatory region sequence-specific DNA binding GO:0000976
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
1 Q9EQQ0 (/IDA)
RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977
Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II.
1 Q9EQQ0 (/IDA)
Chromatin binding GO:0003682
Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.
1 Q9EQQ0 (/IDA)
Methyltransferase activity GO:0008168
Catalysis of the transfer of a methyl group to an acceptor molecule.
1 Q9EQQ0 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q9H5I1 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 Q9EQQ0 (/ISO)
Protein methyltransferase activity GO:0008276
Catalysis of the transfer of a methyl group (CH3-) to a protein.
1 Q9EQQ0 (/IDA)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
1 Q9EQQ0 (/IDA)
Histone-lysine N-methyltransferase activity GO:0018024
Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives.
1 Q9EQQ0 (/IGI)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
1 Q9H5I1 (/IDA)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
1 Q9EQQ0 (/ISO)
Histone methyltransferase activity (H3-K9 specific) GO:0046974
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 9) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 9). This reaction is the addition of a methyl group onto lysine at position 9 of the histone H3 protein.
1 Q9EQQ0 (/ISS)
S-adenosyl-L-methionine binding GO:1904047
Interacting selectively and non-covalently with S-adenosyl-L-methionine.
1 Q9H5I1 (/IDA)
S-adenosyl-L-methionine binding GO:1904047
Interacting selectively and non-covalently with S-adenosyl-L-methionine.
1 Q9EQQ0 (/ISO)

There are 21 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Histone H3-K9 dimethylation GO:0036123
The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone.
6 Q32PH7 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q9H5I1 (/ISS)
Histone H3-K9 trimethylation GO:0036124
The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone.
6 Q32PH7 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q9H5I1 (/ISS)
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
6 Q32PH7 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q9H5I1 (/ISS)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
6 Q32PH7 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q4R3E0 (/ISS) Q9H5I1 (/ISS)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9H5I1 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 Q9EQQ0 (/ISO)
Chromatin assembly or disassembly GO:0006333
The formation or destruction of chromatin structures.
1 Q9H5I1 (/IMP)
Chromatin assembly or disassembly GO:0006333
The formation or destruction of chromatin structures.
1 Q9EQQ0 (/ISO)
Chromatin assembly or disassembly GO:0006333
The formation or destruction of chromatin structures.
1 Q9EQQ0 (/ISS)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 Q9H5I1 (/IDA)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 Q9EQQ0 (/ISO)
Chromatin remodeling GO:0006338
Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation.
1 Q9EQQ0 (/ISS)
Male meiotic nuclear division GO:0007140
A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
1 Q9EQQ0 (/IEP)
Histone lysine methylation GO:0034968
The modification of a histone by addition of one or more methyl groups to a lysine residue.
1 Q9EQQ0 (/IGI)
Histone H3-K9 dimethylation GO:0036123
The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone.
1 Q9EQQ0 (/IMP)
Histone H3-K9 trimethylation GO:0036124
The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone.
1 Q9EQQ0 (/IMP)
Negative regulation of circadian rhythm GO:0042754
Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior.
1 Q9EQQ0 (/IMP)
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
1 Q9EQQ0 (/IMP)
Histone H3-K9 methylation GO:0051567
The modification of histone H3 by addition of one or more methyl groups to lysine at position 9 of the histone.
1 Q9EQQ0 (/IGI)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q9H5I1 (/IDA)
Cellular response to hypoxia GO:0071456
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
1 Q9EQQ0 (/ISO)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 Q9H5I1 (/IDA)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 Q9EQQ0 (/ISO)
Chromatin GO:0000785
The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
1 Q9EQQ0 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q9EQQ0 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9H5I1 (/TAS)
Nuclear heterochromatin GO:0005720
A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin.
1 Q9EQQ0 (/IDA)