The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 16: Metalloproteinase inhibitor 1

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 15 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
25 O02722 (/ISS) P12032 (/ISS) P20414 (/ISS) P20414 (/ISS) P20614 (/ISS) P30120 (/ISS) P35624 (/ISS) P49061 (/ISS) P49061 (/ISS) P49061 (/ISS)
(15 more)
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
25 O02722 (/ISS) P12032 (/ISS) P20414 (/ISS) P20414 (/ISS) P20614 (/ISS) P30120 (/ISS) P35624 (/ISS) P49061 (/ISS) P49061 (/ISS) P49061 (/ISS)
(15 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
8 P01033 (/IPI) P01033 (/IPI) P01033 (/IPI) P01033 (/IPI) P01033 (/IPI) P01033 (/IPI) P01033 (/IPI) P30120 (/IPI)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
7 P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA)
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
7 P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
7 P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA)
Peptidase inhibitor activity GO:0030414
Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
7 P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
2 P20414 (/ISS) P20414 (/ISS)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 P30120 (/IPI)
Protease binding GO:0002020
Interacting selectively and non-covalently with any protease or peptidase.
1 P12032 (/ISO)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
1 P12032 (/ISO)
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
1 P12032 (/ISO)
Metalloendopeptidase inhibitor activity GO:0008191
Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity.
1 P30120 (/TAS)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
1 P12032 (/ISO)
Peptidase inhibitor activity GO:0030414
Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds.
1 P12032 (/ISO)

There are 34 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
25 O02722 (/ISS) P12032 (/ISS) P20414 (/ISS) P20414 (/ISS) P20614 (/ISS) P30120 (/ISS) P35624 (/ISS) P49061 (/ISS) P49061 (/ISS) P49061 (/ISS)
(15 more)
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
25 O02722 (/ISS) P12032 (/ISS) P20414 (/ISS) P20414 (/ISS) P20614 (/ISS) P30120 (/ISS) P35624 (/ISS) P49061 (/ISS) P49061 (/ISS) P49061 (/ISS)
(15 more)
Negative regulation of catalytic activity GO:0043086
Any process that stops or reduces the activity of an enzyme.
25 O02722 (/ISS) P12032 (/ISS) P20414 (/ISS) P20414 (/ISS) P20614 (/ISS) P30120 (/ISS) P35624 (/ISS) P49061 (/ISS) P49061 (/ISS) P49061 (/ISS)
(15 more)
Regulation of integrin-mediated signaling pathway GO:2001044
Any process that modulates the frequency, rate or extent of integrin-mediated signaling pathway.
25 O02722 (/ISS) P12032 (/ISS) P20414 (/ISS) P20414 (/ISS) P20614 (/ISS) P30120 (/ISS) P35624 (/ISS) P49061 (/ISS) P49061 (/ISS) P49061 (/ISS)
(15 more)
Platelet degranulation GO:0002576
The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet.
7 P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
7 P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA)
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
7 P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA)
Cytokine-mediated signaling pathway GO:0019221
A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
7 P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS)
Extracellular matrix disassembly GO:0022617
A process that results in the breakdown of the extracellular matrix.
7 P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS)
Negative regulation of catalytic activity GO:0043086
Any process that stops or reduces the activity of an enzyme.
7 P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
7 P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS)
Cellular protein metabolic process GO:0044267
The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification.
7 P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS)
Negative regulation of membrane protein ectodomain proteolysis GO:0051045
Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.
7 P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA)
Negative regulation of trophoblast cell migration GO:1901164
Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration.
7 P01033 (/IMP) P01033 (/IMP) P01033 (/IMP) P01033 (/IMP) P01033 (/IMP) P01033 (/IMP) P01033 (/IMP)
Negative regulation of metallopeptidase activity GO:1905049
Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity.
7 P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA)
Regulation of integrin-mediated signaling pathway GO:2001044
Any process that modulates the frequency, rate or extent of integrin-mediated signaling pathway.
7 P01033 (/IMP) P01033 (/IMP) P01033 (/IMP) P01033 (/IMP) P01033 (/IMP) P01033 (/IMP) P01033 (/IMP)
Cell activation GO:0001775
A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
1 P30120 (/IMP)
Cell activation GO:0001775
A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand.
1 P12032 (/ISO)
Connective tissue replacement involved in inflammatory response wound healing GO:0002248
The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response.
1 P12032 (/IDA)
Aging GO:0007568
A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700).
1 P30120 (/IEP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 P12032 (/ISO)
Response to organic substance GO:0010033
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus.
1 P30120 (/IEP)
Negative regulation of endopeptidase activity GO:0010951
Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins.
1 P12032 (/ISO)
Response to cytokine GO:0034097
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
1 P30120 (/IEP)
Wound healing GO:0042060
The series of events that restore integrity to a damaged tissue, following an injury.
1 P30120 (/IEP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P30120 (/IMP)
Negative regulation of apoptotic process GO:0043066
Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
1 P12032 (/ISO)
Negative regulation of catalytic activity GO:0043086
Any process that stops or reduces the activity of an enzyme.
1 P12032 (/ISO)
Response to peptide hormone GO:0043434
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals.
1 P30120 (/IEP)
Negative regulation of membrane protein ectodomain proteolysis GO:0051045
Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis.
1 P12032 (/ISO)
Cartilage development GO:0051216
The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate.
1 P30120 (/IEP)
Negative regulation of trophoblast cell migration GO:1901164
Any process that stops, prevents or reduces the frequency, rate or extent of trophoblast cell migration.
1 P12032 (/ISO)
Negative regulation of metallopeptidase activity GO:1905049
Any process that stops, prevents or reduces the frequency, rate or extent of metallopeptidase activity.
1 P12032 (/ISO)
Regulation of integrin-mediated signaling pathway GO:2001044
Any process that modulates the frequency, rate or extent of integrin-mediated signaling pathway.
1 P12032 (/ISO)

There are 12 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
25 O02722 (/ISS) P12032 (/ISS) P20414 (/ISS) P20414 (/ISS) P20614 (/ISS) P30120 (/ISS) P35624 (/ISS) P49061 (/ISS) P49061 (/ISS) P49061 (/ISS)
(15 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
7 P01033 (/NAS) P01033 (/NAS) P01033 (/NAS) P01033 (/NAS) P01033 (/NAS) P01033 (/NAS) P01033 (/NAS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
7 P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
7 P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA) P01033 (/IDA)
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
7 P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS)
Platelet alpha granule lumen GO:0031093
The volume enclosed by the membrane of the platelet alpha granule.
7 P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS) P01033 (/TAS)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
7 P01033 (/HDA) P01033 (/HDA) P01033 (/HDA) P01033 (/HDA) P01033 (/HDA) P01033 (/HDA) P01033 (/HDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
2 P12032 (/IDA) P30120 (/IDA)
Basement membrane GO:0005604
A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers.
1 P12032 (/ISO)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P12032 (/HDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
1 P12032 (/ISO)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
1 P12032 (/IDA)