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CATH Superfamily 2.40.20.10

Plasminogen Kringle 4

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Plasminogen Kringle 4
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 6 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Plasmin. [EC: 3.4.21.7]
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
  • Formed from plasminogen by proteolysis which results in multiple forms of the active plasmin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.14.
 28 O18783 O18783 P00747 P00747 P00747 P06867 P06867 P06867 P06868 P06868
(18 more...)
T-plasminogen activator. [EC: 3.4.21.68]
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
  • From a wide variety of mammalian tissues, especially endothelial cells.
  • Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin.
  • Activity is considerably enhanced by fibrin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.31 and EC 3.4.99.26.
 18 A0A480NSF2 A0A480NSF2 P00750 P00750 P11214 P11214 P15638 P19637 P19637 P49150
(8 more...)
U-plasminogen activator. [EC: 3.4.21.73]
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
  • Formed from the inactive precursor by action of plasmin or plasma kallikrein.
  • Differs in structure from EC 3.4.21.68, and does not bind to fibrin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.21.31 and EC 3.4.99.26.
 11 A0A024QZM9 P00749 P04185 P06869 P15120 P16227 P29598 Q05589 Q0VBA8 Q5RF29
(1 more...)
Thrombin. [EC: 3.4.21.5]
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
  • More selective than trypsin and plasmin.
  • Belongs to peptidase family S1.
  • Formerly EC 3.4.4.13.
 10 P00734 P00734 P00735 P18292 P19221 Q19AZ8 Q19AZ8 Q3TJ94 Q5R537 Q5R537
Receptor protein-tyrosine kinase. [EC: 2.7.10.1]
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
  • The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans.
  • In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies.
  • Formerly EC 2.7.1.112.
 7 D9PTS3 G5EGK5 Q01974 Q24488 Q8AXY6 Q9V6K3 Q9Z138
Coagulation factor XIIa. [EC: 3.4.21.38]
Selective cleavage of Arg-|-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa.
  • Also activates plasma prekallikrein and plasminogen.
  • Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa.
  • Belongs to peptidase family S1.
 6 D3ZTE0 O97507 P00748 P98140 Q04962 Q80YC5