The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cyclophilin-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Peptidyl-prolyl cis-trans isomerase A

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 11 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
402 P10111 (/ISS) P14851 (/ISS) P14851 (/ISS) P17742 (/ISS) P17742 (/ISS) P17742 (/ISS) P17742 (/ISS) P62935 (/ISS) P62935 (/ISS) P62935 (/ISS)
(392 more)
Cyclosporin A binding GO:0016018
Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.
401 P14851 (/ISS) P14851 (/ISS) P17742 (/ISS) P17742 (/ISS) P17742 (/ISS) P17742 (/ISS) P62935 (/ISS) P62935 (/ISS) P62935 (/ISS) P62935 (/ISS)
(391 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
71 P62937 (/IPI) P62937 (/IPI) P62937 (/IPI) P62937 (/IPI) P62937 (/IPI) P62937 (/IPI) P62937 (/IPI) P62937 (/IPI) P62937 (/IPI) P62937 (/IPI)
(61 more)
Cyclosporin A binding GO:0016018
Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.
36 P10111 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA)
(26 more)
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
35 P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA)
(25 more)
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
35 P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA)
(25 more)
Virion binding GO:0046790
Interacting selectively and non-covalently with a virion, either by binding to components of the capsid or the viral envelope.
35 P62937 (/NAS) P62937 (/NAS) P62937 (/NAS) P62937 (/NAS) P62937 (/NAS) P62937 (/NAS) P62937 (/NAS) P62937 (/NAS) P62937 (/NAS) P62937 (/NAS)
(25 more)
Unfolded protein binding GO:0051082
Interacting selectively and non-covalently with an unfolded protein.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
4 P17742 (/ISO) P17742 (/ISO) P17742 (/ISO) P17742 (/ISO)
Cyclosporin A binding GO:0016018
Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids.
4 P17742 (/ISO) P17742 (/ISO) P17742 (/ISO) P17742 (/ISO)
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
1 Q2Y080 (/IPI)

There are 27 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein peptidyl-prolyl isomerization GO:0000413
The modification of a protein by cis-trans isomerization of a proline residue.
402 P10111 (/ISS) P14851 (/ISS) P14851 (/ISS) P17742 (/ISS) P17742 (/ISS) P17742 (/ISS) P17742 (/ISS) P62935 (/ISS) P62935 (/ISS) P62935 (/ISS)
(392 more)
Regulation of viral genome replication GO:0045069
Any process that modulates the frequency, rate or extent of viral genome replication.
402 P10111 (/ISS) P14851 (/ISS) P14851 (/ISS) P17742 (/ISS) P17742 (/ISS) P17742 (/ISS) P17742 (/ISS) P62935 (/ISS) P62935 (/ISS) P62935 (/ISS)
(392 more)
Protein peptidyl-prolyl isomerization GO:0000413
The modification of a protein by cis-trans isomerization of a proline residue.
35 P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA)
(25 more)
RNA-dependent DNA biosynthetic process GO:0006278
A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Viral life cycle GO:0019058
A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Uncoating of virus GO:0019061
The process by which an incoming virus is disassembled in the host cell to release a replication-competent viral genome.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Fusion of virus membrane with host plasma membrane GO:0019064
Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Virion assembly GO:0019068
A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Viral release from host cell GO:0019076
The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Entry into host cell GO:0030260
The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Lipid droplet organization GO:0034389
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.
35 P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP)
(25 more)
Interleukin-12-mediated signaling pathway GO:0035722
A series of molecular signals initiated by the binding of interleukin-12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Neutrophil degranulation GO:0043312
The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Regulation of viral genome replication GO:0045069
Any process that modulates the frequency, rate or extent of viral genome replication.
35 P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP)
(25 more)
Regulation of viral genome replication GO:0045069
Any process that modulates the frequency, rate or extent of viral genome replication.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
35 P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP)
(25 more)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
35 P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP) P62937 (/IMP)
(25 more)
Leukocyte migration GO:0050900
The movement of a leukocyte within or between different tissues and organs of the body.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Establishment of integrated proviral latency GO:0075713
A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Protein peptidyl-prolyl isomerization GO:0000413
The modification of a protein by cis-trans isomerization of a proline residue.
4 P17742 (/ISO) P17742 (/ISO) P17742 (/ISO) P17742 (/ISO)
Neuron differentiation GO:0030182
The process in which a relatively unspecialized cell acquires specialized features of a neuron.
4 P17742 (/IMP) P17742 (/IMP) P17742 (/IMP) P17742 (/IMP)
Lipid droplet organization GO:0034389
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lipid particle.
4 P17742 (/ISO) P17742 (/ISO) P17742 (/ISO) P17742 (/ISO)
Regulation of viral genome replication GO:0045069
Any process that modulates the frequency, rate or extent of viral genome replication.
4 P17742 (/ISO) P17742 (/ISO) P17742 (/ISO) P17742 (/ISO)
Positive regulation of viral genome replication GO:0045070
Any process that activates or increases the frequency, rate or extent of viral genome replication.
4 P17742 (/ISO) P17742 (/ISO) P17742 (/ISO) P17742 (/ISO)
Positive regulation of protein secretion GO:0050714
Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell.
4 P17742 (/ISO) P17742 (/ISO) P17742 (/ISO) P17742 (/ISO)
Negative regulation of phosphoprotein phosphatase activity GO:0032515
Any process that stops or reduces the activity of a phosphoprotein phosphatase.
1 P10111 (/IDA)

There are 19 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
402 P10111 (/ISS) P14851 (/ISS) P14851 (/ISS) P17742 (/ISS) P17742 (/ISS) P17742 (/ISS) P17742 (/ISS) P62935 (/ISS) P62935 (/ISS) P62935 (/ISS)
(392 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
402 P10111 (/ISS) P14851 (/ISS) P14851 (/ISS) P17742 (/ISS) P17742 (/ISS) P17742 (/ISS) P17742 (/ISS) P62935 (/ISS) P62935 (/ISS) P62935 (/ISS)
(392 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
39 P17742 (/HDA) P17742 (/HDA) P17742 (/HDA) P17742 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA)
(29 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
36 P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA)
(26 more)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
35 P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA)
(25 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
35 P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA)
(25 more)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Focal adhesion GO:0005925
Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments.
35 P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA)
(25 more)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
35 P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA)
(25 more)
Vesicle GO:0031982
Any small, fluid-filled, spherical organelle enclosed by membrane.
35 P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA) P62937 (/HDA)
(25 more)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
35 P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA) P62937 (/IDA)
(25 more)
Secretory granule lumen GO:0034774
The volume enclosed by the membrane of a secretory granule.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Ficolin-1-rich granule lumen GO:1904813
Any membrane-enclosed lumen that is part of a ficolin-1-rich granule.
35 P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS) P62937 (/TAS)
(25 more)
Protein-containing complex GO:0032991
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
4 P17742 (/ISO) P17742 (/ISO) P17742 (/ISO) P17742 (/ISO)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
4 P17742 (/HDA) P17742 (/HDA) P17742 (/HDA) P17742 (/HDA)
Midbody GO:0030496
A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
2 P14851 (/IDA) P14851 (/IDA)
Cell GO:0005623
The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope.
1 D0EKR3 (/IDA)