The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 66: Peptidyl-prolyl cis-trans isomerase

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 6 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
5 P22696 (/IDA) P22696 (/IDA) Q59KZ2 (/IDA) Q59KZ2 (/IDA) Q59KZ2 (/IDA)
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
3 Q59KZ2 (/IGI) Q59KZ2 (/IGI) Q59KZ2 (/IGI)
RNA polymerase II complex binding GO:0000993
Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits.
2 P22696 (/IPI) P22696 (/IPI)
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
2 P22696 (/IMP) P22696 (/IMP)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P22696 (/IPI) P22696 (/IPI)
Peptidyl-prolyl cis-trans isomerase activity GO:0003755
Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
1 O74448 (/ISO)

There are 31 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cellular response to starvation GO:0009267
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment.
3 Q59KZ2 (/IMP) Q59KZ2 (/IMP) Q59KZ2 (/IMP)
Pathogenesis GO:0009405
The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism.
3 Q59KZ2 (/IMP) Q59KZ2 (/IMP) Q59KZ2 (/IMP)
Filamentous growth GO:0030447
The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.
3 Q59KZ2 (/IMP) Q59KZ2 (/IMP) Q59KZ2 (/IMP)
Cellular response to heat GO:0034605
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
3 Q59KZ2 (/IMP) Q59KZ2 (/IMP) Q59KZ2 (/IMP)
Filamentous growth of a population of unicellular organisms in response to heat GO:0036168
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature.
3 Q59KZ2 (/IMP) Q59KZ2 (/IMP) Q59KZ2 (/IMP)
Filamentous growth of a population of unicellular organisms in response to starvation GO:0036170
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.
3 Q59KZ2 (/IMP) Q59KZ2 (/IMP) Q59KZ2 (/IMP)
Filamentous growth of a population of unicellular organisms in response to biotic stimulus GO:0036180
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.
3 Q59KZ2 (/IMP) Q59KZ2 (/IMP) Q59KZ2 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P22696 (/IGI) P22696 (/IGI)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
2 P22696 (/IMP) P22696 (/IMP)
Protein peptidyl-prolyl isomerization GO:0000413
The modification of a protein by cis-trans isomerization of a proline residue.
2 P22696 (/IDA) P22696 (/IDA)
Protein peptidyl-prolyl isomerization GO:0000413
The modification of a protein by cis-trans isomerization of a proline residue.
2 P22696 (/IMP) P22696 (/IMP)
Termination of RNA polymerase II transcription GO:0006369
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.
2 P22696 (/IGI) P22696 (/IGI)
Termination of RNA polymerase II transcription GO:0006369
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.
2 P22696 (/IMP) P22696 (/IMP)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
2 C8V2B0 (/IMP) C8V2B0 (/IMP)
Negative regulation of histone deacetylation GO:0031064
Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones.
2 P22696 (/IMP) P22696 (/IMP)
Negative regulation of histone deacetylation GO:0031064
Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones.
2 P22696 (/IPI) P22696 (/IPI)
Positive regulation of protein dephosphorylation GO:0035307
Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.
2 P22696 (/IDA) P22696 (/IDA)
Positive regulation of protein dephosphorylation GO:0035307
Any process that activates or increases the frequency, rate or extent of removal of phosphate groups from a protein.
2 P22696 (/IMP) P22696 (/IMP)
Positive regulation of RNA polymerase II transcriptional preinitiation complex assembly GO:0045899
Any process that activates or increases the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly.
2 P22696 (/IGI) P22696 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P22696 (/IGI) P22696 (/IGI)
Positive regulation of transcription by RNA polymerase II GO:0045944
Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
2 P22696 (/IPI) P22696 (/IPI)
Histone H3-K4 trimethylation GO:0080182
The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.
2 P22696 (/IGI) P22696 (/IGI)
Histone H3-K4 trimethylation GO:0080182
The modification of histone H3 by addition of three methyl groups to lysine at position 4 of the histone.
2 P22696 (/IMP) P22696 (/IMP)
Regulation of phosphorylation of RNA polymerase II C-terminal domain GO:1901407
Any process that modulates the frequency, rate or extent of phosphorylation of RNA polymerase II C-terminal domain.
2 P22696 (/IDA) P22696 (/IDA)
Negative regulation of ubiquitin-dependent protein catabolic process GO:2000059
Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-dependent protein catabolic process
2 P22696 (/IMP) P22696 (/IMP)
Positive regulation of chromatin silencing at rDNA GO:2000749
Any process that activates or increases the frequency, rate or extent of chromatin silencing at rDNA.
2 P22696 (/IMP) P22696 (/IMP)
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
1 O74448 (/ISO)
Termination of RNA polymerase II transcription GO:0006369
The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed.
1 O74448 (/ISO)
Protein folding GO:0006457
The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure.
1 O74448 (/IC)
MRNA 3'-end processing GO:0031124
Any process involved in forming the mature 3' end of an mRNA molecule.
1 O74448 (/ISO)
Regulation of transcription elongation from RNA polymerase II promoter GO:0034243
Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.
1 O74448 (/ISO)

There are 3 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
2 P22696 (/IC) P22696 (/IC)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O74448 (/HDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 O74448 (/IDA)