CATH Superfamily 2.20.70.10
The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.
FunFam 44: E3 ubiquitin-protein ligase SMURF2
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 11 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | A2A5Z6 (/IPI) Q9HAU4 (/IPI) Q9HAU4 (/IPI) Q9HAU4 (/IPI) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
4 | F1M3F2 (/IPI) Q9HAU4 (/IPI) Q9HAU4 (/IPI) Q9HAU4 (/IPI) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
4 | A2A5Z6 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
3 | Q9HAU4 (/IDA) Q9HAU4 (/IDA) Q9HAU4 (/IDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
3 | Q9HAU4 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
3 | Q9HAU4 (/IPI) Q9HAU4 (/IPI) Q9HAU4 (/IPI) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | A2A5Z6 (/ISO) |
|
Transforming growth factor beta receptor binding GO:0005160
Interacting selectively and non-covalently with the transforming growth factor beta receptor.
|
1 | F1M3F2 (/IPI) |
|
Transforming growth factor beta receptor binding GO:0005160
Interacting selectively and non-covalently with the transforming growth factor beta receptor.
|
1 | A2A5Z6 (/ISO) |
|
Identical protein binding GO:0042802
Interacting selectively and non-covalently with an identical protein or proteins.
|
1 | A2A5Z6 (/ISO) |
|
SMAD binding GO:0046332
Interacting selectively and non-covalently with a SMAD signaling protein.
|
1 | A2A5Z6 (/ISO) |
There are 17 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Negative regulation of transcription by RNA polymerase II GO:0000122
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II.
|
3 | Q9HAU4 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) |
|
Protein polyubiquitination GO:0000209
Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain.
|
3 | Q9HAU4 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
3 | Q9HAU4 (/IDA) Q9HAU4 (/IDA) Q9HAU4 (/IDA) |
|
Protein deubiquitination GO:0016579
The removal of one or more ubiquitin groups from a protein.
|
3 | Q9HAU4 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) |
|
Regulation of transforming growth factor beta receptor signaling pathway GO:0017015
Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway.
|
3 | Q9HAU4 (/NAS) Q9HAU4 (/NAS) Q9HAU4 (/NAS) |
|
BMP signaling pathway GO:0030509
A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
|
3 | Q9HAU4 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) |
|
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
|
3 | Q9HAU4 (/IDA) Q9HAU4 (/IDA) Q9HAU4 (/IDA) |
|
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
|
3 | Q9HAU4 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) |
|
Ubiquitin-dependent SMAD protein catabolic process GO:0030579
The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.
|
3 | Q9HAU4 (/IDA) Q9HAU4 (/IDA) Q9HAU4 (/IDA) |
|
Negative regulation of transcription, DNA-templated GO:0045892
Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
|
3 | Q9HAU4 (/NAS) Q9HAU4 (/NAS) Q9HAU4 (/NAS) |
|
Wnt signaling pathway, planar cell polarity pathway GO:0060071
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors including C-Jun N-terminal kinase (JNK) to modulate cytoskeletal elements and control cell polarity.
|
3 | Q9HAU4 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) |
|
Positive regulation of canonical Wnt signaling pathway GO:0090263
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
|
3 | Q9HAU4 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) |
|
Positive regulation of trophoblast cell migration GO:1901165
Any process that activates or increases the frequency, rate or extent of trophoblast cell migration.
|
3 | Q9HAU4 (/IDA) Q9HAU4 (/IDA) Q9HAU4 (/IDA) |
|
Ubiquitin-dependent protein catabolic process GO:0006511
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein.
|
1 | A2A5Z6 (/ISO) |
|
Negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway.
|
1 | A2A5Z6 (/ISO) |
|
Ubiquitin-dependent SMAD protein catabolic process GO:0030579
The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome.
|
1 | A2A5Z6 (/ISO) |
|
Positive regulation of trophoblast cell migration GO:1901165
Any process that activates or increases the frequency, rate or extent of trophoblast cell migration.
|
1 | A2A5Z6 (/ISO) |
There are 7 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
6 | J3QQM4 (/IDA) J3QQM4 (/IDA) J3QQM4 (/IDA) Q9HAU4 (/IDA) Q9HAU4 (/IDA) Q9HAU4 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
4 | A2A5Z6 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) |
|
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
3 | Q9HAU4 (/IDA) Q9HAU4 (/IDA) Q9HAU4 (/IDA) |
|
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
|
3 | Q9HAU4 (/NAS) Q9HAU4 (/NAS) Q9HAU4 (/NAS) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q9HAU4 (/TAS) Q9HAU4 (/TAS) Q9HAU4 (/TAS) |
|
Ubiquitin ligase complex GO:0000151
A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex.
|
1 | A2A5Z6 (/ISO) |
|
Nuclear speck GO:0016607
A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy.
|
1 | A2A5Z6 (/ISO) |