The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 6: F-box only protein 5

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 9 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquitin ligase inhibitor activity GO:1990948
Stops, prevents or reduces the activity of a ubiquitin ligase.
7 Q0V967 (/ISS) Q28GK6 (/ISS) Q4V7W2 (/ISS) Q4V7W2 (/ISS) Q7TSG3 (/ISS) Q90Z80 (/ISS) Q90Z80 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
6 Q7TSG3 (/IPI) Q8AXF4 (/IPI) Q8CDI2 (/IPI) Q90Z80 (/IPI) Q90Z80 (/IPI) Q9UKT4 (/IPI)
Anaphase-promoting complex binding GO:0010997
Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.
1 Q9UKT4 (/IDA)
Anaphase-promoting complex binding GO:0010997
Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.
1 Q7TSG3 (/ISO)
Anaphase-promoting complex binding GO:0010997
Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.
1 Q7TSG3 (/ISS)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q9UKT4 (/IPI)
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
1 Q7TSG3 (/ISO)
Ubiquitin ligase inhibitor activity GO:1990948
Stops, prevents or reduces the activity of a ubiquitin ligase.
1 Q9UKT4 (/IDA)
Ubiquitin ligase inhibitor activity GO:1990948
Stops, prevents or reduces the activity of a ubiquitin ligase.
1 Q7TSG3 (/ISO)

There are 66 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Negative regulation of ubiquitin protein ligase activity GO:1904667
Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity.
5 Q0V967 (/ISS) Q28GK6 (/ISS) Q4V7W2 (/ISS) Q4V7W2 (/ISS) Q7TSG3 (/ISS)
Negative regulation of mitotic metaphase/anaphase transition GO:0045841
Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
3 Q90Z80 (/IDA) Q90Z80 (/IDA) Q9UKT4 (/IDA)
Negative regulation of mitotic metaphase/anaphase transition GO:0045841
Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
3 Q28GK6 (/ISS) Q4V7W2 (/ISS) Q4V7W2 (/ISS)
Mitotic cell cycle arrest GO:0071850
The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M).
3 Q28GK6 (/ISS) Q4V7W2 (/ISS) Q4V7W2 (/ISS)
Negative regulation of exit from meiosis GO:0106061
Any process that stops, prevents or reduces the frequency, rate or extent of exit from meiosis.
3 Q28GK6 (/ISS) Q4V7W2 (/ISS) Q4V7W2 (/ISS)
Negative regulation of ubiquitin protein ligase activity GO:1904667
Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity.
3 Q90Z80 (/IDA) Q90Z80 (/IDA) Q9UKT4 (/IDA)
Regulation of DNA replication GO:0006275
Any process that modulates the frequency, rate or extent of DNA replication.
2 Q28GK6 (/ISS) Q7TSG3 (/ISS)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
2 Q0V967 (/ISS) Q9UKT4 (/ISS)
Mitotic cell cycle arrest GO:0071850
The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M).
2 Q90Z80 (/IDA) Q90Z80 (/IDA)
Negative regulation of exit from meiosis GO:0106061
Any process that stops, prevents or reduces the frequency, rate or extent of exit from meiosis.
2 Q90Z80 (/IMP) Q90Z80 (/IMP)
Regulation of transcription involved in G1/S transition of mitotic cell cycle GO:0000083
Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle.
1 Q9UKT4 (/TAS)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
1 Q0V967 (/IMP)
Mitotic cytokinesis GO:0000281
A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells.
1 Q0V967 (/IMP)
Oocyte maturation GO:0001556
A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
1 Q7TSG3 (/IDA)
Oocyte maturation GO:0001556
A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization.
1 Q7TSG3 (/IMP)
Regulation of DNA replication GO:0006275
Any process that modulates the frequency, rate or extent of DNA replication.
1 Q9UKT4 (/IMP)
Regulation of DNA replication GO:0006275
Any process that modulates the frequency, rate or extent of DNA replication.
1 Q7TSG3 (/ISO)
Spindle assembly involved in female meiosis I GO:0007057
The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster.
1 Q7TSG3 (/IDA)
Regulation of mitotic cell cycle GO:0007346
Any process that modulates the rate or extent of progress through the mitotic cell cycle.
1 Q7TSG3 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q9UKT4 (/IMP)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q7TSG3 (/ISO)
Positive regulation of cell population proliferation GO:0008284
Any process that activates or increases the rate or extent of cell proliferation.
1 Q28GK6 (/ISS)
Positive regulation of G2/M transition of mitotic cell cycle GO:0010971
Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
1 Q9UKT4 (/IMP)
Positive regulation of G2/M transition of mitotic cell cycle GO:0010971
Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
1 Q7TSG3 (/ISO)
Positive regulation of G2/M transition of mitotic cell cycle GO:0010971
Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle.
1 Q7TSG3 (/ISS)
Vesicle organization GO:0016050
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.
1 Q7TSG3 (/IDA)
Hemopoiesis GO:0030097
The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates.
1 Q0V967 (/IMP)
Anaphase-promoting complex-dependent catabolic process GO:0031145
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.
1 Q9UKT4 (/TAS)
Negative regulation of DNA endoreduplication GO:0032876
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication.
1 Q9UKT4 (/IMP)
Negative regulation of DNA endoreduplication GO:0032876
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication.
1 Q7TSG3 (/ISO)
Negative regulation of DNA endoreduplication GO:0032876
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication.
1 Q7TSG3 (/ISS)
Regulation of meiotic nuclear division GO:0040020
Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.
1 Q7TSG3 (/IDA)
Regulation of meiotic nuclear division GO:0040020
Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.
1 Q8CDI2 (/IGI)
Negative regulation of protein catabolic process GO:0042177
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.
1 Q8CDI2 (/IMP)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
1 Q9UKT4 (/IMP)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
1 Q7TSG3 (/ISO)
Positive regulation of osteoblast differentiation GO:0045669
Any process that activates or increases the frequency, rate or extent of osteoblast differentiation.
1 Q7TSG3 (/ISS)
Negative regulation of meiotic nuclear division GO:0045835
Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
1 Q7TSG3 (/IDA)
Negative regulation of meiotic nuclear division GO:0045835
Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
1 Q8CDI2 (/IGI)
Negative regulation of meiotic nuclear division GO:0045835
Any process that stops, prevents, or reduces the frequency, rate or extent of meiosis.
1 Q8CDI2 (/IMP)
Negative regulation of mitotic nuclear division GO:0045839
Any process that stops, prevents or reduces the rate or extent of mitosis. Mitosis is the division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother.
1 Q0V967 (/IMP)
Negative regulation of mitotic metaphase/anaphase transition GO:0045841
Any process that stops, prevents, or reduces the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin.
1 Q7TSG3 (/ISO)
Microtubule polymerization GO:0046785
The addition of tubulin heterodimers to one or both ends of a microtubule.
1 Q7TSG3 (/IDA)
Spindle assembly GO:0051225
The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.
1 Q7TSG3 (/IDA)
Chromosome organization GO:0051276
A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome.
1 Q0V967 (/IMP)
Cell division GO:0051301
The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.
1 Q0V967 (/IMP)
Negative regulation of ubiquitin-protein transferase activity GO:0051444
Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity.
1 Q9UKT4 (/IDA)
Negative regulation of ubiquitin-protein transferase activity GO:0051444
Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity.
1 Q7TSG3 (/ISO)
Negative regulation of ubiquitin-protein transferase activity GO:0051444
Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin transferase activity.
1 Q7TSG3 (/ISS)
Regulation of cell cycle GO:0051726
Any process that modulates the rate or extent of progression through the cell cycle.
1 Q0V967 (/IMP)
Positive regulation of meiosis I GO:0060903
Any process that increases the rate, frequency, or extent of meiosis I, a cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells.
1 Q7TSG3 (/ISO)
Positive regulation of biomineral tissue development GO:0070169
Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
1 Q9UKT4 (/IMP)
Positive regulation of biomineral tissue development GO:0070169
Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
1 Q7TSG3 (/ISO)
Positive regulation of biomineral tissue development GO:0070169
Any process that activates or increases the frequency, rate or extent of biomineral tissue development, the formation of hard tissues that consist mainly of inorganic compounds.
1 Q7TSG3 (/ISS)
Regulation of mitotic cell cycle phase transition GO:1901990
Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition.
1 Q9UKT4 (/TAS)
Negative regulation of ubiquitin protein ligase activity GO:1904667
Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity.
1 Q9UKT4 (/IMP)
Negative regulation of ubiquitin protein ligase activity GO:1904667
Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin protein ligase activity.
1 Q7TSG3 (/ISO)
Positive regulation of mesenchymal stem cell migration GO:1905322
Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration.
1 Q9UKT4 (/IMP)
Positive regulation of mesenchymal stem cell migration GO:1905322
Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration.
1 Q7TSG3 (/ISO)
Positive regulation of mesenchymal stem cell migration GO:1905322
Any process that activates or increases the frequency, rate or extent of mesenchymal stem cell migration.
1 Q7TSG3 (/ISS)
Negative regulation of cellular senescence GO:2000773
Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.
1 Q9UKT4 (/IMP)
Negative regulation of cellular senescence GO:2000773
Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.
1 Q7TSG3 (/ISO)
Negative regulation of cellular senescence GO:2000773
Any process that stops, prevents or reduces the frequency, rate or extent of cellular senescence.
1 Q7TSG3 (/ISS)
Negative regulation of response to DNA damage stimulus GO:2001021
Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus.
1 Q9UKT4 (/IMP)
Negative regulation of response to DNA damage stimulus GO:2001021
Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus.
1 Q7TSG3 (/ISO)
Negative regulation of response to DNA damage stimulus GO:2001021
Any process that stops, prevents or reduces the frequency, rate or extent of response to DNA damage stimulus.
1 Q7TSG3 (/ISS)

There are 15 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
5 Q0V967 (/ISS) Q28GK6 (/ISS) Q4V7W2 (/ISS) Q4V7W2 (/ISS) Q7TSG3 (/ISS)
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
5 Q0V967 (/ISS) Q28GK6 (/ISS) Q4V7W2 (/ISS) Q4V7W2 (/ISS) Q7TSG3 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
4 Q8CDI2 (/IDA) Q90Z80 (/IDA) Q90Z80 (/IDA) Q9UKT4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q7TSG3 (/IDA) Q90Z80 (/IDA) Q90Z80 (/IDA) Q9UKT4 (/IDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 Q0V967 (/ISS) Q28GK6 (/ISS) Q4V7W2 (/ISS) Q4V7W2 (/ISS)
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
3 Q90Z80 (/IDA) Q90Z80 (/IDA) Q9UKT4 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q7TSG3 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9UKT4 (/IDA)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q7TSG3 (/ISO)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
1 Q9UKT4 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 Q7TSG3 (/ISO)
Spindle GO:0005819
The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart.
1 Q7TSG3 (/ISO)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q9UKT4 (/TAS)
Meiotic spindle GO:0072687
A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.
1 Q7TSG3 (/IDA)
Meiotic spindle GO:0072687
A spindle that forms as part of meiosis. Several proteins, such as budding yeast Spo21p, fission yeast Spo2 and Spo13, and C. elegans mei-1, localize specifically to the meiotic spindle and are absent from the mitotic spindle.
1 Q9UKT4 (/ISS)