The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 9: DNA-directed RNA polymerase subunit

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 3 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
DNA-directed 5'-3' RNA polymerase activity GO:0003899
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
Zinc ion binding GO:0008270
Interacting selectively and non-covalently with zinc (Zn) ions.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
DNA-directed 5'-3' RNA polymerase activity GO:0003899
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
7 P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P36958 (/ISS)

There are 17 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
148 P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P60898 (/ISS) P60898 (/ISS) P60898 (/ISS)
(138 more)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
140 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(130 more)
MRNA splicing, via spliceosome GO:0000398
The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
Transcription-coupled nucleotide-excision repair GO:0006283
The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
Transcription, DNA-templated GO:0006351
The cellular synthesis of RNA on a template of DNA.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
70 P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA)
(60 more)
Transcription by RNA polymerase II GO:0006366
The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs).
70 P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO)
(60 more)
Transcription initiation from RNA polymerase II promoter GO:0006367
Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
Transcription elongation from RNA polymerase II promoter GO:0006368
The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
7-methylguanosine mRNA capping GO:0006370
Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
Fibroblast growth factor receptor signaling pathway GO:0008543
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
RNA metabolic process GO:0016070
The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
Somatic stem cell population maintenance GO:0035019
Any process by which an organism retains a population of somatic stem cells, undifferentiated cells in the embryo or adult which can undergo unlimited division and give rise to cell types of the body other than those of the germ-line.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
SnRNA transcription by RNA polymerase II GO:0042795
The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
Positive regulation of viral transcription GO:0050434
Any process that activates or increases the frequency, rate or extent of viral transcription.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
Regulation of gene silencing by miRNA GO:0060964
Any process that modulates the rate, frequency, or extent of the downregulation of gene expression through the action of microRNAs (miRNAs), endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate gene expression by either of two posttranscriptional mechanisms: RNA (often mRNA) cleavage or mRNA translational repression.
70 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(60 more)
Mitotic cell cycle GO:0000278
Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
7 P36958 (/HMP) P36958 (/HMP) P36958 (/HMP) P36958 (/HMP) P36958 (/HMP) P36958 (/HMP) P36958 (/HMP)

There are 9 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
RNA polymerase II, core complex GO:0005665
RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
148 P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P36958 (/ISS) P60898 (/ISS) P60898 (/ISS) P60898 (/ISS)
(138 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
141 P60898 (/ISS) P60898 (/ISS) P60898 (/ISS) P60898 (/ISS) P60898 (/ISS) P60898 (/ISS) P60898 (/ISS) P60898 (/ISS) P60898 (/ISS) P60898 (/ISS)
(131 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
140 P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS) P36954 (/TAS)
(130 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
77 P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA)
(67 more)
RNA polymerase II, core complex GO:0005665
RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
77 P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA)
(67 more)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
70 P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO)
(60 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
70 P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA) P36954 (/IDA)
(60 more)
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
70 P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO)
(60 more)
RNA polymerase II, core complex GO:0005665
RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template.
70 P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO) P60898 (/ISO)
(60 more)