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CATH Superfamily 2.20.110.10

Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Histone-lysine N-methyltransferase. [EC: 2.1.1.43]
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
    		 30 A0A2I3HBF0 A0A2I3HBF0 A0A2I3HBF0 A0A2K5TYA5 A0A2K5TYA5 A0A2K5TYA5 A0A2K6E1K4 A0A2K6E1K4 A0A2K6E1K4 A0A2R8ZT30
    (20 more...)
    1-phosphatidylinositol-4-phosphate 5-kinase. [EC: 2.7.1.68]
    ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl- 1D-myo-inositol 4,5-bisphosphate.
    • This enzyme can also phosphorylate PtdIns3P in the 4-position, and PtdIns, PtdIns3P and PtdIns(3,4)P(2) in the 5-position in vitro, but to a lesser extent.
    • The last of these reactions occurs in vivo and is physiologically relevant.
    		 16 A0A178VQ77 A0A178W750 A0A178W978 A0A178WK69 A0A384KKN2 O48709 Q0WN55 Q56YP2 Q6EX42 Q8L796
    (6 more...)