The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Thrombospondin type-1 (TSP1) repeat
".
FunFam 24: Spondin-1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 4 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
|
3 | F1S981 (/RCA) Q8VCC9 (/RCA) Q9HCB6 (/RCA) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
2 | Q8VCC9 (/IPI) Q9HCB6 (/IPI) |
|
Extracellular matrix structural constituent GO:0005201
The action of a molecule that contributes to the structural integrity of the extracellular matrix.
|
1 | Q9HCB6 (/ISS) |
|
LBD domain binding GO:0050693
Interacting selectively and non-covalently with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket.
|
1 | Q8VCC9 (/IPI) |
There are 4 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Positive regulation of protein processing GO:0010954
Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage.
|
1 | Q8VCC9 (/IDA) |
|
Positive regulation of protein binding GO:0032092
Any process that activates or increases the frequency, rate or extent of protein binding.
|
1 | Q8VCC9 (/IDA) |
|
Negative regulation of amyloid-beta formation GO:1902430
Any process that stops, prevents or reduces the frequency, rate or extent of amyloid-beta formation.
|
1 | Q8VCC9 (/IDA) |
|
Positive regulation of amyloid precursor protein catabolic process GO:1902993
Any process that activates or increases the frequency, rate or extent of amyloid precursor protein catabolic process.
|
1 | Q8VCC9 (/IDA) |
There are 4 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
|
8 | A0A0B5JWB5 (/IDA) A0A2R8QEU8 (/IDA) A0A2R8QJ71 (/IDA) A0A2R8QPZ7 (/IDA) A2BFS0 (/IDA) B3DH64 (/IDA) F1R2Z9 (/IDA) O42114 (/IDA) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
1 | Q9HCB6 (/HDA) |
|
Endoplasmic reticulum lumen GO:0005788
The volume enclosed by the membranes of the endoplasmic reticulum.
|
1 | Q9HCB6 (/TAS) |
|
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
|
1 | Q8VCC9 (/HDA) |