The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 2: Translationally-controlled tumor protein homolog

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 4 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Calcium ion binding GO:0005509
Interacting selectively and non-covalently with calcium ions (Ca2+).
6 Q293Y0 (/ISS) Q293Y0 (/ISS) Q6XIN1 (/ISS) Q9VGS2 (/ISS) Q9VGS2 (/ISS) Q9VGS2 (/ISS)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 Q10344 (/IPI) Q9VGS2 (/IPI) Q9VGS2 (/IPI) Q9VGS2 (/IPI)
Guanyl-nucleotide exchange factor activity GO:0005085
Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase.
3 Q9VGS2 (/IDA) Q9VGS2 (/IDA) Q9VGS2 (/IDA)
Guanyl nucleotide exchange factor inhibitor activity GO:1990624
Stops, prevents or reduces the activity of a guanyl nucleotide exchange factor.
1 Q10344 (/ISO)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
7 P35691 (/IMP) P35691 (/IMP) P35691 (/IMP) P35691 (/IMP) P35691 (/IMP) P35691 (/IMP) P35691 (/IMP)
Negative regulation of microtubule depolymerization GO:0007026
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
7 P35691 (/IMP) P35691 (/IMP) P35691 (/IMP) P35691 (/IMP) P35691 (/IMP) P35691 (/IMP) P35691 (/IMP)
Cellular response to oxidative stress GO:0034599
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
7 P35691 (/IMP) P35691 (/IMP) P35691 (/IMP) P35691 (/IMP) P35691 (/IMP) P35691 (/IMP) P35691 (/IMP)
Double-strand break repair GO:0006302
The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.
3 Q9VGS2 (/IMP) Q9VGS2 (/IMP) Q9VGS2 (/IMP)
Mitotic G2 DNA damage checkpoint GO:0007095
A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.
3 Q9VGS2 (/IMP) Q9VGS2 (/IMP) Q9VGS2 (/IMP)
Intra-S DNA damage checkpoint GO:0031573
A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
3 Q9VGS2 (/IMP) Q9VGS2 (/IMP) Q9VGS2 (/IMP)
Positive regulation of histone phosphorylation GO:0033129
Any process that activates or increases the frequency, rate or extent of the addition of one or more phosphate groups to a histone protein.
3 Q9VGS2 (/IDA) Q9VGS2 (/IDA) Q9VGS2 (/IDA)
Positive regulation of multicellular organism growth GO:0040018
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.
3 Q9VGS2 (/IMP) Q9VGS2 (/IMP) Q9VGS2 (/IMP)
Positive regulation of cell size GO:0045793
Any process that increases cell size.
3 Q9VGS2 (/IMP) Q9VGS2 (/IMP) Q9VGS2 (/IMP)
Cellular response to gamma radiation GO:0071480
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum.
3 Q9VGS2 (/IMP) Q9VGS2 (/IMP) Q9VGS2 (/IMP)
Regulation of stem cell differentiation GO:2000736
Any process that modulates the frequency, rate or extent of stem cell differentiation.
3 Q9VGS2 (/IMP) Q9VGS2 (/IMP) Q9VGS2 (/IMP)
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
2 A1KXP4 (/ISS) D0MQ50 (/ISS)
Negative regulation of microtubule depolymerization GO:0007026
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.
2 A1KXP4 (/ISS) D0MQ50 (/ISS)
Cytoplasmic translation GO:0002181
The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.
1 Q10344 (/ISO)

There are 13 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
7 P35691 (/HDA) P35691 (/HDA) P35691 (/HDA) P35691 (/HDA) P35691 (/HDA) P35691 (/HDA) P35691 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
7 P35691 (/IDA) P35691 (/IDA) P35691 (/IDA) P35691 (/IDA) P35691 (/IDA) P35691 (/IDA) P35691 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
7 P35691 (/IDA) P35691 (/IDA) P35691 (/IDA) P35691 (/IDA) P35691 (/IDA) P35691 (/IDA) P35691 (/IDA)
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
7 P35691 (/IDA) P35691 (/IDA) P35691 (/IDA) P35691 (/IDA) P35691 (/IDA) P35691 (/IDA) P35691 (/IDA)
Cytoplasmic microtubule GO:0005881
Any microtubule in the cytoplasm of a cell.
6 Q293Y0 (/ISS) Q293Y0 (/ISS) Q6XIN1 (/ISS) Q9VGS2 (/ISS) Q9VGS2 (/ISS) Q9VGS2 (/ISS)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 Q9VGS2 (/IDA) Q9VGS2 (/IDA) Q9VGS2 (/IDA)
Polytene chromosome GO:0005700
A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible.
3 Q9VGS2 (/IDA) Q9VGS2 (/IDA) Q9VGS2 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 Q9VGS2 (/HDA) Q9VGS2 (/HDA) Q9VGS2 (/HDA)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
2 Q293Y0 (/ISS) Q293Y0 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
2 A1KXP4 (/ISS) D0MQ50 (/ISS)
Fungal biofilm matrix GO:0062040
An extracellular matrix lying external to fungal cells. The fungal biofilm matrix consists of polysaccharides, proteins, lipids, and nucleic acids. Fungal biofilms mediate adherence to host tissues, and provide protection from host immune defenses.
2 Q5A860 (/IDA) Q5A860 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 Q10344 (/HDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 Q10344 (/HDA)