View in Gene3D

CATH Superfamily 2.160.20.60

Glutamate synthase, alpha subunit, C-terminal domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glutamate synthase, alpha subunit, C-terminal domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 4 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Formylmethanofuran dehydrogenase. [EC: 1.2.7.12]
Formylmethanofuran + H(2)O + 2 oxidized ferredoxin [iron-sulfur] cluster = CO(2) + methanofuran + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+).
  • The enzyme catalyzes a reversible reaction in methanogenic archaea, and is involved in methanogenesis from CO(2) as well as the oxidation of coenzyme M to CO(2).
  • The reaction is endergonic, and is driven by coupling with the soluble CoB-CoM heterodisulfide reductase via electron bifurcation.
  • Formerly EC 1.2.99.5.
 17 A0A0E3QQT1 A0A0E3QQT1 A0A1M4MT83 A0A223ZFU6 A0A371NEU4 O27002 O27600 O74031 P0CW42 P0CW43
(7 more...)
Glutamate synthase (NADPH). [EC: 1.4.1.13]
2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH.
  • The reaction takes place in the opposite direction.
  • The protein is composed of two subunits, alpha and beta.
  • The alpha subunit is composed of two domains, one hydrolyzing L-glutamine to NH(3) and L-glutamate (cf. EC 3.5.1.2), the other combining the produced NH(3) with 2-oxoglutarate to produce a second molecule of L-glutamate (cf. EC 1.4.1.4).
  • The beta subunit transfers electrons to the cosubstrate.
  • The NH(3) is channeled through a 31 A channel in the active protein.
  • In the absence of the beta subunit, coupling between the two domains of the alpha subunit is compromised and some ammonium can be produced.
  • In the intact alpha-beta complex, ammonia production only takes place as part of the overall reaction.
  • Formerly EC 2.6.1.53.
 17 A0A045GNB6 A0A094WIN3 A0A0E1M1Z9 A0A0E1SR53 A0A0H3LFY7 A0A164XVV7 A0A236RJL2 A0A402RMP7 A5U9I8 E1V8I1
(7 more...)
Glutamate synthase (ferredoxin). [EC: 1.4.7.1]
2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H(+).
  • The protein is composed of two domains, one hydrolyzing L-glutamine to NH(3) and L-glutamate (cf. EC 3.5.1.2), the other combining the produced NH(3) with 2-oxoglutarate to produce a second molecule of L-glutamate.
  • The NH(3) is channeled through a 24 A channel in the active protein.
  • No hydrolysis of glutamine takes place without ferredoxin and 2-oxoglutarate being bound to the protein.
 12 A0A178UNU3 O19906 P23225 P51375 P55037 P55038 Q06434 Q1XDB2 Q43155 Q69RJ0
(2 more...)
Glutamate synthase (NADH). [EC: 1.4.1.14]
2 L-glutamate + NAD(+) = L-glutamine + 2-oxoglutarate + NADH.
  • A flavoprotein (FMN).
  • The reaction takes place in the direction of L-glutamate production.
  • The protein is composed of two domains, one hydrolyzing L-glutamine to NH(3) and L-glutamate (cf. EC 3.5.1.2), the other combining the produced NH(3) with 2-oxoglutarate to produce a second molecule of L-glutamate (cf. EC 1.4.1.2).
 7 G2WBZ3 N1P7N3 Q03460 Q0DG35 Q0JKD0 Q12680 Q9LV03