The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Nitrite reductase NirS

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Hydroxylamine reductase. [EC: 1.7.99.1]
NH(3) + H(2)O + acceptor = hydroxylamine + reduced acceptor.
  • Reduced pyocyanine, methylene blue and flavins act as donors for the reduction of hydroxylamine.
  • May be identical to EC 1.7.2.1.
49 A0A0C7D2E8 A0A0C7D2E8 A0A0C7D2E8 A0A0C7D2E8 A0A0C7D2E8 A0A0C7D2E8 A0A0C7D2E8 A0A1F0IXV3 A0A1F0IXV3 A0A1F0IXV3
(39 more...)
Nitrite reductase (NO-forming). [EC: 1.7.2.1]
Nitric oxide + H(2)O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H(+).
  • The reaction is catalyzed by two types of enzymes, found in the perimplasm of denitrifying bacteria.
  • One type comprises proteins containing multiple copper centers, the other a heme protein, cytochrome cd1.
  • Acceptors include c-type cytochromes such as cytochrome c-550 or cytochrome c-551 from Paracoccus denitrificans or Pseudomonas aeruginosa, and small blue copper proteins such as azurin and pseudoazurin.
  • Cytochrome cd1 also has oxidase and hydroxylamine reductase activities.
  • May also catalyze the reaction of EC 1.7.99.1 since this is a well- known activity of cytochrome cd1.
  • Formerly EC 1.6.6.5, EC 1.7.99.3 and EC 1.9.3.2.
49 A0A0C7D2E8 A0A0C7D2E8 A0A0C7D2E8 A0A0C7D2E8 A0A0C7D2E8 A0A0C7D2E8 A0A0C7D2E8 A0A1F0IXV3 A0A1F0IXV3 A0A1F0IXV3
(39 more...)