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CATH Superfamily 2.130.10.80

Galactose oxidase/kelch, beta-propeller

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Galactose oxidase/kelch, beta-propeller
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 2 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Galactose oxidase. [EC: 1.1.3.9]
D-galactose + O(2) = D-galacto-hexodialdose + H(2)O(2).
    		 4 A0A1I9FQV9 A0A2H3HJK8 I1S2N3 P0CS93
    Aldehyde oxidase. [EC: 1.2.3.1]
    An aldehyde + H(2)O + O(2) = a carboxylate + H(2)O(2).
    • The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides.
    • The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11).
    • Formerly EC 1.2.3.11.
    		 4 A0A178W3X1 Q01772 Q3HRQ2 Q9FYG4