The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Integrin alpha, N-terminal
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 11: Glycosylphosphatidylinositol specific phospholipas...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 5 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Sodium channel regulator activity GO:0017080
Modulates the activity of a sodium channel.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Glycosylphosphatidylinositol phospholipase D activity GO:0004621
Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol.
2 P80108 (/IDA) Q8R2H5 (/IDA)
Glycosylphosphatidylinositol phospholipase D activity GO:0004621
Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol.
2 G1QNK4 (/ISS) G3R160 (/ISS)
Glycosylphosphatidylinositol phospholipase D activity GO:0004621
Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol.
2 P80108 (/TAS) Q8R2H5 (/TAS)
Phospholipase D activity GO:0004630
Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate.
1 P80108 (/IDA)

There are 52 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ossification GO:0001503
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Chondrocyte differentiation GO:0002062
The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Positive regulation of alkaline phosphatase activity GO:0010694
Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Positive regulation of triglyceride biosynthetic process GO:0010867
Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Negative regulation of triglyceride catabolic process GO:0010897
Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Positive regulation of glucose metabolic process GO:0010907
Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Positive regulation of high-density lipoprotein particle clearance GO:0010983
Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Phosphatidylcholine metabolic process GO:0046470
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Positive regulation of secretion GO:0051047
Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Transepithelial transport GO:0070633
The directed movement of a substance from one side of an epithelium to the other.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Complement receptor mediated signaling pathway GO:0002430
A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
GPI anchor release GO:0006507
The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Positive regulation of cytolysis GO:0045919
Any process that activates or increases the frequency, rate or extent of cytolysis.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Positive regulation of membrane protein ectodomain proteolysis GO:0051044
Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Cellular response to cholesterol GO:0071397
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Cellular response to triglyceride GO:0071401
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Cellular response to pH GO:0071467
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Regulation of cellular response to insulin stimulus GO:1900076
Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 P80108 (/IDA) Q8R2H5 (/IDA)
Cellular response to calcium ion GO:0071277
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus.
2 G1QNK4 (/ISS) G3R160 (/ISS)
Cell migration involved in sprouting angiogenesis GO:0002042
The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis.
1 P80108 (/IMP)
Complement receptor mediated signaling pathway GO:0002430
A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway.
1 P80108 (/IDA)
C-terminal protein lipidation GO:0006501
The covalent attachment of a lipid group to the carboxy-terminus of a protein.
1 P80108 (/TAS)
GPI anchor release GO:0006507
The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane.
1 P80108 (/IDA)
GPI anchor release GO:0006507
The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane.
1 P80108 (/IMP)
Negative regulation of cell population proliferation GO:0008285
Any process that stops, prevents or reduces the rate or extent of cell proliferation.
1 P80108 (/IDA)
Insulin receptor signaling pathway GO:0008286
The series of molecular signals generated as a consequence of the insulin receptor binding to insulin.
1 P80108 (/IDA)
Response to glucose GO:0009749
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus.
1 P80108 (/IDA)
Positive regulation of endothelial cell migration GO:0010595
Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium.
1 P80108 (/IMP)
Cellular response to insulin stimulus GO:0032869
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
1 P80108 (/IDA)
Cellular response to drug GO:0035690
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P80108 (/IDA)
Hematopoietic stem cell migration GO:0035701
The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.
1 P80108 (/TAS)
Positive regulation of apoptotic process GO:0043065
Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process.
1 P80108 (/IDA)
Positive regulation of cytolysis GO:0045919
Any process that activates or increases the frequency, rate or extent of cytolysis.
1 P80108 (/IDA)
Phosphatidylcholine metabolic process GO:0046470
The chemical reactions and pathways involving phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline. They are important constituents of cell membranes.
1 P80108 (/TAS)
Positive regulation of membrane protein ectodomain proteolysis GO:0051044
Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis.
1 P80108 (/IDA)
Cellular response to inorganic substance GO:0071241
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus.
1 Q8R2H5 (/IDA)
Cellular response to iron(II) ion GO:0071282
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus.
1 Q8R2H5 (/IDA)
Cellular response to cholesterol GO:0071397
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cholesterol stimulus.
1 P80108 (/IMP)
Cellular response to triglyceride GO:0071401
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a triglyceride stimulus.
1 P80108 (/IMP)
Cellular response to pH GO:0071467
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.
1 P80108 (/IDA)
Hematopoietic stem cell migration to bone marrow GO:0097241
The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.
1 P80108 (/TAS)
Regulation of cellular response to insulin stimulus GO:1900076
Any process that modulates the frequency, rate or extent of cellular response to insulin stimulus.
1 P80108 (/IDA)

There are 10 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Extracellular matrix GO:0031012
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.
4 G1QNK4 (/ISS) G3R160 (/ISS) P80108 (/ISS) Q8R2H5 (/ISS)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
3 G1QNK4 (/ISS) G3R160 (/ISS) Q8R2H5 (/ISS)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 P80108 (/IDA) Q8R2H5 (/IDA)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
2 G1QNK4 (/ISS) G3R160 (/ISS)
Extracellular region GO:0005576
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
1 P80108 (/TAS)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 P80108 (/IDA)
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
1 P80108 (/HDA)
Intracellular membrane-bounded organelle GO:0043231
Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
1 P80108 (/IDA)
Extracellular exosome GO:0070062
A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm.
1 P80108 (/HDA)