The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"YVTN repeat-like/Quinoprotein amine dehydrogenase
".
FunFam 72: Regulatory-associated protein of MTOR, complex 1
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 21 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
4 | Q8K4Q0 (/IPI) Q8N122 (/IPI) Q8N122 (/IPI) Q8N122 (/IPI) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
4 | D3ZDU2 (/IPI) Q8N122 (/IPI) Q8N122 (/IPI) Q8N122 (/IPI) |
|
RNA polymerase III type 1 promoter DNA binding GO:0001030
Interacting selectively and non-covalently with a region of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
RNA polymerase III type 2 promoter DNA binding GO:0001031
Interacting selectively and non-covalently with a region of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
RNA polymerase III type 3 promoter DNA binding GO:0001032
Interacting selectively and non-covalently with a region of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
TFIIIC-class transcription factor complex binding GO:0001156
Interacting selectively and non-covalently with a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Protein serine/threonine kinase inhibitor activity GO:0030291
Stops, prevents or reduces the activity of a protein serine/threonine kinase.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Protein kinase activator activity GO:0030295
Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
3 | Q8N122 (/IPI) Q8N122 (/IPI) Q8N122 (/IPI) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
RNA polymerase III type 1 promoter DNA binding GO:0001030
Interacting selectively and non-covalently with a region of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition.
|
1 | Q8K4Q0 (/ISO) |
|
RNA polymerase III type 2 promoter DNA binding GO:0001031
Interacting selectively and non-covalently with a region of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs.
|
1 | Q8K4Q0 (/ISO) |
|
RNA polymerase III type 3 promoter DNA binding GO:0001032
Interacting selectively and non-covalently with a region of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae.
|
1 | Q8K4Q0 (/ISO) |
|
TFIIIC-class transcription factor complex binding GO:0001156
Interacting selectively and non-covalently with a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III.
|
1 | Q8K4Q0 (/ISO) |
|
Protein kinase binding GO:0019901
Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate.
|
1 | Q8K4Q0 (/ISO) |
|
Protein serine/threonine kinase inhibitor activity GO:0030291
Stops, prevents or reduces the activity of a protein serine/threonine kinase.
|
1 | Q8K4Q0 (/ISO) |
|
Protein kinase activator activity GO:0030295
Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein.
|
1 | Q8K4Q0 (/ISO) |
|
Protein binding, bridging GO:0030674
The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
|
1 | Q8K4Q0 (/ISO) |
|
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
|
1 | Q8K4Q0 (/ISO) |
|
14-3-3 protein binding GO:0071889
Interacting selectively and non-covalently with a 14-3-3 protein. A 14-3-3 protein is any of a large family of approximately 30kDa acidic proteins which exist primarily as homo- and heterodimers within all eukaryotic cells, and have been implicated in the modulation of distinct biological processes by binding to specific phosphorylated sites on diverse target proteins, thereby forcing conformational changes or influencing interactions between their targets and other molecules. Each 14-3-3 protein sequence can be roughly divided into three sections: a divergent amino terminus, the conserved core region and a divergent carboxy-terminus. The conserved middle core region of the 14-3-3s encodes an amphipathic groove that forms the main functional domain, a cradle for interacting with client proteins.
|
1 | Q8K4Q0 (/ISO) |
There are 42 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
|
3 | Q8N122 (/IMP) Q8N122 (/IMP) Q8N122 (/IMP) |
|
Cell cycle arrest GO:0007050
A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M).
|
3 | Q8N122 (/TAS) Q8N122 (/TAS) Q8N122 (/TAS) |
|
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
|
3 | Q8N122 (/IMP) Q8N122 (/IMP) Q8N122 (/IMP) |
|
Positive regulation of peptidyl-threonine phosphorylation GO:0010800
Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
3 | Q8N122 (/IMP) Q8N122 (/IMP) Q8N122 (/IMP) |
|
Regulation of macroautophagy GO:0016241
Any process that modulates the frequency, rate or extent of macroautophagy.
|
3 | Q8N122 (/TAS) Q8N122 (/TAS) Q8N122 (/TAS) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
3 | Q8N122 (/IMP) Q8N122 (/IMP) Q8N122 (/IMP) |
|
Cellular response to nutrient levels GO:0031669
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
3 | Q8N122 (/IMP) Q8N122 (/IMP) Q8N122 (/IMP) |
|
TOR signaling GO:0031929
A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
3 | Q8N122 (/IMP) Q8N122 (/IMP) Q8N122 (/IMP) |
|
TORC1 signaling GO:0038202
A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.
|
3 | Q8N122 (/IMP) Q8N122 (/IMP) Q8N122 (/IMP) |
|
Positive regulation of transcription by RNA polymerase III GO:0045945
Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III.
|
3 | Q8N122 (/IMP) Q8N122 (/IMP) Q8N122 (/IMP) |
|
Cellular response to amino acid stimulus GO:0071230
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
|
3 | Q8N122 (/IMP) Q8N122 (/IMP) Q8N122 (/IMP) |
|
Cellular response to leucine GO:0071233
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Regulation of cellular response to heat GO:1900034
Any process that modulates the frequency, rate or extent of cellular response to heat.
|
3 | Q8N122 (/TAS) Q8N122 (/TAS) Q8N122 (/TAS) |
|
Positive regulation of G1/S transition of mitotic cell cycle GO:1900087
Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
3 | Q8N122 (/IMP) Q8N122 (/IMP) Q8N122 (/IMP) |
|
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
|
1 | Q8K4Q0 (/ISO) |
|
Regulation of cell growth GO:0001558
Any process that modulates the frequency, rate, extent or direction of cell growth.
|
1 | Q8K4Q0 (/ISS) |
|
Regulation of protein phosphorylation GO:0001932
Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein.
|
1 | Q8K4Q0 (/IMP) |
|
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
|
1 | D3ZDU2 (/IMP) |
|
Positive regulation of endothelial cell proliferation GO:0001938
Any process that activates or increases the rate or extent of endothelial cell proliferation.
|
1 | Q8K4Q0 (/ISO) |
|
Regulation of cell size GO:0008361
Any process that modulates the size of a cell.
|
1 | Q8K4Q0 (/ISO) |
|
Positive regulation of peptidyl-threonine phosphorylation GO:0010800
Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
|
1 | Q8K4Q0 (/ISO) |
|
Positive regulation of cell growth GO:0030307
Any process that activates or increases the frequency, rate, extent or direction of cell growth.
|
1 | Q8K4Q0 (/ISO) |
|
Cellular response to nutrient levels GO:0031669
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.
|
1 | Q8K4Q0 (/ISO) |
|
TOR signaling GO:0031929
A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
|
1 | Q8K4Q0 (/ISO) |
|
TOR signaling GO:0031929
A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.
|
1 | Q8K4Q0 (/ISS) |
|
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
|
1 | Q8K4Q0 (/ISO) |
|
Positive regulation of TOR signaling GO:0032008
Any process that activates or increases the frequency, rate or extent of TOR signaling.
|
1 | Q8K4Q0 (/ISS) |
|
Positive regulation of peptidyl-serine phosphorylation GO:0033138
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.
|
1 | Q8K4Q0 (/ISO) |
|
TORC1 signaling GO:0038202
A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.
|
1 | Q8K4Q0 (/ISO) |
|
Regulation of phosphorylation GO:0042325
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
|
1 | D3ZDU2 (/IMP) |
|
Regulation of phosphorylation GO:0042325
Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule.
|
1 | Q8K4Q0 (/ISO) |
|
Positive regulation of transcription by RNA polymerase III GO:0045945
Any process that activates or increases the frequency, rate or extent of transcription mediated by RNA polymerase III.
|
1 | Q8K4Q0 (/ISO) |
|
Negative regulation of insulin secretion GO:0046676
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
|
1 | Q8K4Q0 (/IMP) |
|
Cellular response to amino acid stimulus GO:0071230
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
|
1 | Q8K4Q0 (/ISO) |
|
Cellular response to amino acid stimulus GO:0071230
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups.
|
1 | Q8K4Q0 (/ISS) |
|
Cellular response to leucine GO:0071233
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus.
|
1 | Q8K4Q0 (/ISO) |
|
Positive regulation of protein serine/threonine kinase activity GO:0071902
Any process that increases the rate, frequency, or extent of protein serine/threonine kinase activity.
|
1 | Q8K4Q0 (/ISO) |
|
Positive regulation of G1/S transition of mitotic cell cycle GO:1900087
Any signalling pathway that increases or activates a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
|
1 | Q8K4Q0 (/ISO) |
|
Positive regulation of asexual reproduction GO:1903666
Any process that activates or increases the frequency, rate or extent of asexual reproduction.
|
1 | Q55BR7 (/IMP) |
There are 21 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
3 | Q8N122 (/TAS) Q8N122 (/TAS) Q8N122 (/TAS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
3 | Q8N122 (/IMP) Q8N122 (/IMP) Q8N122 (/IMP) |
|
Lysosomal membrane GO:0005765
The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.
|
3 | Q8N122 (/HDA) Q8N122 (/HDA) Q8N122 (/HDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
3 | Q8N122 (/TAS) Q8N122 (/TAS) Q8N122 (/TAS) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
TORC1 complex GO:0031931
A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.
|
3 | Q8N122 (/IDA) Q8N122 (/IDA) Q8N122 (/IDA) |
|
Nucleoplasm GO:0005654
That part of the nuclear content other than the chromosomes or the nucleolus.
|
1 | Q8K4Q0 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8K4Q0 (/ISO) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q8K4Q0 (/ISS) |
|
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
1 | Q8K4Q0 (/ISO) |
|
Lysosome GO:0005764
A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.
|
1 | Q8K4Q0 (/ISS) |
|
Autophagosome GO:0005776
A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy.
|
1 | Q55BR7 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q8K4Q0 (/ISO) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
1 | Q8K4Q0 (/ISO) |
|
Cytoplasmic stress granule GO:0010494
A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress.
|
1 | Q8K4Q0 (/ISS) |
|
TORC1 complex GO:0031931
A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.
|
1 | Q8K4Q0 (/ISO) |
|
TORC1 complex GO:0031931
A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.
|
1 | Q8K4Q0 (/ISS) |