The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Kelch-type beta propeller
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 25: Kelch-like family member 41

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 1 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
4 O60662 (/IPI) O60662 (/IPI) O60662 (/IPI) Q9ER30 (/IPI)

There are 26 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
4 O60662 (/ISS) O60662 (/ISS) O60662 (/ISS) Q9ER30 (/ISS)
Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
4 O60662 (/ISS) O60662 (/ISS) O60662 (/ISS) Q9ER30 (/ISS)
Regulation of myoblast differentiation GO:0045661
Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
4 O60662 (/ISS) O60662 (/ISS) O60662 (/ISS) Q9ER30 (/ISS)
Regulation of myoblast proliferation GO:2000291
Any process that modulates the frequency, rate or extent of myoblast proliferation.
4 O60662 (/ISS) O60662 (/ISS) O60662 (/ISS) Q9ER30 (/ISS)
Striated muscle contraction GO:0006941
A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope.
3 O60662 (/TAS) O60662 (/TAS) O60662 (/TAS)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
3 O60662 (/IDA) O60662 (/IDA) O60662 (/IDA)
Post-translational protein modification GO:0043687
The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome.
3 O60662 (/TAS) O60662 (/TAS) O60662 (/TAS)
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
3 E9QIN8 (/IMP) E9QJ30 (/IMP) F1QEG2 (/IMP)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
2 E9QIN8 (/IGI) F1QEG2 (/IGI)
Sarcomere organization GO:0045214
The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs.
2 E9QIN8 (/IMP) F1QEG2 (/IMP)
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
2 E9QIN8 (/IGI) F1QEG2 (/IGI)
Protein ubiquitination GO:0016567
The process in which one or more ubiquitin groups are added to a protein.
1 A2AUC9 (/ISO)
Myofibril assembly GO:0030239
Formation of myofibrils, the repeating units of striated muscle.
1 A2AUC9 (/IMP)
Regulation of lateral pseudopodium assembly GO:0031275
Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell.
1 Q9ER30 (/IMP)
Regulation of lateral pseudopodium assembly GO:0031275
Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell.
1 A2AUC9 (/ISO)
Positive regulation of protein ubiquitination GO:0031398
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.
1 E9QJ30 (/ISS)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
1 E9QJ30 (/ISS)
Skeletal muscle cell differentiation GO:0035914
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.
1 A2AUC9 (/IDA)
Swimming GO:0036268
Self-propelled movement of an organism from one location to another through water, often by means of active fin movement.
1 E9QJ30 (/IGI)
Regulation of myoblast differentiation GO:0045661
Any process that modulates the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers.
1 A2AUC9 (/IMP)
Skeletal muscle fiber development GO:0048741
The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast.
1 E9QJ30 (/ISS)
Muscle structure development GO:0061061
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
1 E9QJ30 (/IGI)
Muscle structure development GO:0061061
The progression of a muscle structure over time, from its formation to its mature state. Muscle structures are contractile cells, tissues or organs that are found in multicellular organisms.
1 E9QJ30 (/IMP)
Skeletal muscle fiber differentiation GO:0098528
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract.
1 E9QJ30 (/ISS)
Regulation of myoblast proliferation GO:2000291
Any process that modulates the frequency, rate or extent of myoblast proliferation.
1 A2AUC9 (/IMP)
Regulation of skeletal muscle cell differentiation GO:2001014
Any process that modulates the frequency, rate or extent of skeletal muscle cell differentiation.
1 A2AUC9 (/IMP)

There are 25 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
5 A2AUC9 (/IDA) O60662 (/IDA) O60662 (/IDA) O60662 (/IDA) Q9ER30 (/IDA)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
4 A2AUC9 (/IDA) O60662 (/IDA) O60662 (/IDA) O60662 (/IDA)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
4 O60662 (/ISS) O60662 (/ISS) O60662 (/ISS) Q9ER30 (/ISS)
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
4 O60662 (/ISS) O60662 (/ISS) O60662 (/ISS) Q9ER30 (/ISS)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
4 A2AUC9 (/IDA) O60662 (/IDA) O60662 (/IDA) O60662 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
3 O60662 (/IDA) O60662 (/IDA) O60662 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O60662 (/IDA) O60662 (/IDA) O60662 (/IDA)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
3 O60662 (/TAS) O60662 (/TAS) O60662 (/TAS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
3 O60662 (/IDA) O60662 (/IDA) O60662 (/IDA)
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
3 O60662 (/IDA) O60662 (/IDA) O60662 (/IDA)
Nucleus GO:0005634
A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
1 A2AUC9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 A2AUC9 (/ISO)
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
1 E9QJ30 (/ISS)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 A2AUC9 (/ISO)
Endoplasmic reticulum membrane GO:0005789
The lipid bilayer surrounding the endoplasmic reticulum.
1 Q9ER30 (/ISS)
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
1 A2AUC9 (/ISO)
Cytoskeleton GO:0005856
Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
1 A2AUC9 (/IDA)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
1 A2AUC9 (/ISO)
Pseudopodium GO:0031143
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.
1 Q9ER30 (/IDA)
Pseudopodium GO:0031143
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.
1 A2AUC9 (/ISO)
M band GO:0031430
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.
1 A2AUC9 (/IDA)
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
1 A2AUC9 (/ISO)
Cul3-RING ubiquitin ligase complex GO:0031463
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
1 E9QJ30 (/ISS)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
1 A2AUC9 (/ISO)
Sarcoplasmic reticulum membrane GO:0033017
The lipid bilayer surrounding the sarcoplasmic reticulum.
1 Q9ER30 (/ISS)