The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"TolB, C-terminal domain
".
FunFam 50: E3 ubiquitin-protein ligase TRIM56
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
2 | E1BD59 (/ISS) Q9BRZ2 (/ISS) |
|
RNA binding GO:0003723
Interacting selectively and non-covalently with an RNA molecule or a portion thereof.
|
1 | Q9BRZ2 (/HDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q80VI1 (/IDA) |
|
Ubiquitin-protein transferase activity GO:0004842
Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
|
1 | Q9BRZ2 (/TAS) |
|
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
|
1 | Q80VI1 (/IPI) |
|
Ubiquitin protein ligase activity GO:0061630
Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
|
1 | Q80VI1 (/IDA) |
There are 12 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Interferon-beta production GO:0032608
The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
2 | E1BD59 (/ISS) Q9BRZ2 (/ISS) |
|
Response to type I interferon GO:0034340
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
2 | E1BD59 (/ISS) Q9BRZ2 (/ISS) |
|
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
2 | E1BD59 (/ISS) Q9BRZ2 (/ISS) |
|
Protein K63-linked ubiquitination GO:0070534
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
|
2 | E1BD59 (/ISS) Q9BRZ2 (/ISS) |
|
Regulation of type I interferon production GO:0032479
Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
1 | Q9BRZ2 (/TAS) |
|
Interferon-beta production GO:0032608
The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.
|
1 | Q80VI1 (/IMP) |
|
Response to type I interferon GO:0034340
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a type I interferon stimulus. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.
|
1 | Q80VI1 (/IDA) |
|
Innate immune response GO:0045087
Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens.
|
1 | Q80VI1 (/IDA) |
|
Negative regulation of viral entry into host cell GO:0046597
Any process that stops, prevents, or reduces the frequency, rate or extent of the entry of viral entry into a host cell.
|
1 | Q80VI1 (/IDA) |
|
Defense response to virus GO:0051607
Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
|
1 | Q80VI1 (/IMP) |
|
Protein K63-linked ubiquitination GO:0070534
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 63 of the ubiquitin monomers, is added to a protein. K63-linked ubiquitination does not target the substrate protein for degradation, but is involved in several pathways, notably as a signal to promote error-free DNA postreplication repair.
|
1 | Q80VI1 (/IDA) |
|
Negative regulation of viral release from host cell GO:1902187
Any process that stops, prevents or reduces the frequency, rate or extent of viral release from host cell.
|
1 | Q80VI1 (/IDA) |
There are 3 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
2 | E1BD59 (/ISS) Q9BRZ2 (/ISS) |
|
Cytoplasm GO:0005737
All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
|
1 | Q80VI1 (/IDA) |
|
Cytosol GO:0005829
The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
|
1 | Q9BRZ2 (/TAS) |