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CATH Superfamily 2.115.10.20

Glycosyl hydrolase domain; family 43

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Glycosyl hydrolase domain; family 43
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily EC Annotations

Note: the EC figure is not being displayed for this superfamily as there are more than 100 different EC terms.

There are 19 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
Beta-fructofuranosidase. [EC: 3.2.1.26]
Hydrolysis of terminal non-reducing beta-D-fructofuranoside residues in beta-D-fructofuranosides.
  • Substrates include sucrose.
  • Also catalyzes fructotransferase reactions.
 96 A0A0A6QH52 A0A0E0U7Q0 A0A0H3Q966 A0A0H7HPC8 A0A0K9TBX9 A0A0K9USA0 A0A0X1L0B3 A0A164UN16 A0A1B2B7X5 A0A1D3KIU9
(86 more...)
Arabinan endo-1,5-alpha-L-arabinosidase. [EC: 3.2.1.99]
Endohydrolysis of (1->5)-alpha-arabinofuranosidic linkages in (1->5)- arabinans.
  • Acts best on linear 1,5-alpha-L-arabinan.
  • Also acts on branched arabinan, but more slowly.
 61 A0A0J5PF32 A0A0T8PJB7 A0A162R4I3 A0A164WUU8 A0A1B2B7Z1 A0A1D8FKX2 A0A1S9D7N6 A0A229YAZ8 A0A254TR00 A0A254U0C0
(51 more...)
Non-reducing end alpha-L-arabinofuranosidase. [EC: 3.2.1.55]
Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.
  • Acts on alpha-L-arabinofuranosides, alpha-L-arabinans containing (1,3)- and/or (1,5)-linkages, arabinoxylans and arabinogalactans.
  • Some EC 3.2.1.23 and EC 3.2.1.38 enzymes also hydrolyze alpha-L- arabinosides.
  • cf. EC 3.2.1.185.
  • Formerly EC 3.2.1.79.
 47 A0A164XML2 A0A1B1YC13 A0A1B1YJ57 A0A1I4UDG1 A0A254U9U2 A0A2P2HVC1 A0A319AIC0 A0A370C2G3 A0A373GMI7 A0A378Y077
(37 more...)
Levansucrase. [EC: 2.4.1.10]
Sucrose + (6)-beta-D-fructofuranosyl-(2->)(n) alpha-D-glucopyranoside = glucose + (6)-beta-D-fructofuranosyl-(2->)(n+1) alpha-D-glucopyranoside.
  • Some other sugars can act as D-fructosyl acceptors.
 28 A0A0F3HMB8 A0A0T8PV47 A0A1D8FMD8 A0A2R4RQY0 A0A2R4S339 A0A2R9NV92 A0A2Z6PZ65 A0PFL2 A8S4C2 A9H664
(18 more...)
Xylan 1,4-beta-xylosidase. [EC: 3.2.1.37]
Hydrolysis of (1->4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.
  • Also hydrolyzes xylobiose.
  • Some other exoglycosidase activities have been found associated with this enzyme in sheep liver.
 25 A0A162SFQ4 A0A1B1YC13 A0A1B1YJ57 A0A1I4UDG1 A0A373GMI7 A0A3A6M959 A7M2P9 B2KZK6 C3QNM7 D7J7H6
(15 more...)
Fructan beta-fructosidase. [EC: 3.2.1.80]
Hydrolysis of terminal, non-reducing (2->1)- and (2->6)-linked beta-D- fructofuranose residues in fructans.
  • Hydrolyzes inulin and levan, and also sucrose.
 21 A0A164X0F8 A0A254U960 A0A319AAC9 A0A370C814 A0A401KQK6 A0A410R3B2 A2R0E0 A5DHM6 A8W7I5 B6CAT0
(11 more...)
4-O-beta-D-mannosyl-D-glucose phosphorylase. [EC: 2.4.1.281]
4-O-beta-D-mannopyranosyl-D-glucopyranose + phosphate = D-glucose + alpha-D-mannose 1-phosphate.
  • This enzyme forms part of a mannan catabolic pathway in the anaerobic bacterium Bacteroides fragilis NCTC 9343.
 16 A0A015TNE0 A0A015V9Z1 A0A015VHP4 A0A015XLJ7 A0A016CTN4 A0A016G253 A0A016GK89 A0A017NGY3 A0A0E2RVV3 A0A0E2TGE7
(6 more...)
Fructan beta-(2,1)-fructosidase. [EC: 3.2.1.153]
Hydrolysis of terminal, non-reducing (2->1)-linked beta-D-fructofuranose residues in fructans.
  • Possesses one of the activities of EC 3.2.1.80.
  • While the best substrates are the inulin-type fructans, such as 1-kestose (beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D-glucopyranoside) and 1,1-nystose (beta-D-fructofuranosyl- (2->1)-beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D- glucopyranoside), some (but not all) levan-type fructans can also be hydrolyzed, but more slowly (see EC 3.2.1.154).
  • Sucrose, while being a very poor substrate, can substantially inhibit enzyme activity in some cases.
 11 A0A446V3H0 A0A452XG83 B6DXP5 B6DZC8 B6DZD0 B6DZD1 B6DZD2 D2IGW7 Q70AT7 Q84LA1
(1 more...)
Inulinase. [EC: 3.2.1.7]
Endohydrolysis of (2->1)-beta-D-fructosidic linkages in inulin.
    		 10 A0A068FCL2 A0A370C679 A0A401KM89 A0A401L2X5 A5ABL2 B3GQU5 O74641 O74642 O94220 P28999
    2,6-beta-fructan 6-levanbiohydrolase. [EC: 3.2.1.64]
    Hydrolysis of (2->6)-beta-D-fructofuranan, to remove successive disaccharide residues as levanbiose, i.e. 6-(beta-D-fructofuranosyl)-D- fructose, from the end of the chain.
      		 6 A0A162QP87 A0A1D8FV84 A0A2X1X435 L8AVC4 O07003 P94469
      Inulosucrase. [EC: 2.4.1.9]
      Sucrose + ((2->1)-beta-D-fructosyl)(n) = glucose + ((2->1)-beta-D- fructosyl)(n+1).
      • Converts sucrose into inulin and D-glucose.
      • Some other sugars can act as D-fructosyl acceptors.
      		 2 D3WYV9 Q74K42
      1,4-beta-mannosyl-N-acetylglucosamine phosphorylase. [EC: 2.4.1.320]
      4-O-beta-D-mannopyranosyl-N-acetyl-D-glucosamine + phosphate = N-acetyl- D-glucosamine + alpha-D-mannose 1-phosphate.
      • The enzyme isolated from the anaerobic bacterium Bacteroides thetaiotaomicron is involved in the degradation of host-derived N-glycans.
      		 2 A0A174QT01 Q8A8Y4
      6(G)-fructosyltransferase. [EC: 2.4.1.243]
      (1-beta-D-fructofuranosyl-(2->1)-)(m+1) alpha-D-glucopyranoside + (1-beta-D-fructofuranosyl-(2->1)-)(n+1) alpha-D-glucopyranoside = (1-beta-D-fructofuranosyl-(2->1)-)(m) alpha-D-glucopyranoside + (1-beta- D-fructofuranosyl-(2->1)-)(n+1) beta-D-fructofuranosyl-(2->6)-alpha-D- glucopyranoside (m > 0, n >= 0).
      • This enzyme catalyzes the transfer of the terminal (2->1)-linked beta-D-fructosyl group of a mono- or oligosaccharide substituent on O-1 of the fructose residue of sucrose onto O-6 of its glucose residue.
      • For example, if 1-kestose (1(F)-(beta-D-fructofuranosyl)sucrose) is both the donor and recipient in the reaction shown above, i.e., if m = 1 and n = 1, then the products will be sucrose and 6(G)-di-beta-D- fructofuranosylsucrose.
      • In this notation, the superscripts F and G are used to specify whether the fructose or glucose residue of the sucrose carries the substituent; alternatively, this may be indicated by the presence and/or absence of primes.
      • Sucrose cannot be a donor substrate in the reaction (i.e. m cannot be zero) and inulin cannot act as an acceptor.
      • Side reactions catalyzed are transfer of a beta-D-fructosyl group between compounds of the structure 1(F)-(1-beta-D- fructofuranosyl)(m)-6(G)-(1-beta-D-fructofuranosyl)(n) sucrose, where m >= 0 and n = 1 for the donor, and m >= 0 and n >= 0 for the acceptor.
      		 2 P92916 Q5FC15
      Fructan beta-(2,6)-fructosidase. [EC: 3.2.1.154]
      Hydrolysis of terminal, non-reducing (2->6)-linked beta-D-fructofuranose residues in fructans.
      • Possesses one of the activities of EC 3.2.1.80.
      • While the best substrates are the levan-type fructans such as 6-kestotriose (beta-D-fructofuranosyl-(2->6)-beta-D-fructofuranosyl alpha-D-glucopyranoside) and 6,6-kestotetraose (beta-D- fructofuranosyl-(2->6)-beta-D-fructofuranosyl-(2->6)-beta-D- fructofuranosyl alpha-D-glucopyranoside), some (but not all) inulin- type fructans can also be hydrolyzed, but more slowly (cf. EC 3.2.1.153).
      • Sucrose, while being a very poor substrate, can substantially inhibit enzyme activity in some cases.
      		 2 Q2UXF7 Q70XE6
      Levanase. [EC: 3.2.1.65]
      Random hydrolysis of (2->6)-beta-D-fructofuranosidic linkages in (2->6)- beta-D-fructans (levans) containing more than 3 fructose units.
        		 1 O31411
        2,1-fructan:2,1-fructan 1-fructosyltransferase. [EC: 2.4.1.100]
        (Beta-D-fructosyl-(2->1)-)(m) + (beta-D-fructosyl-(2->1)-)(n) = (beta-D- fructosyl-(2->1)-)(m-1) + (beta-D-fructosyl-(2->1)-)(n+1).
          		 1 P92916
          Beta-1,4-mannooligosaccharide phosphorylase. [EC: 2.4.1.319]
          ((1->4)-beta-D-mannosyl)(n) + phosphate = ((1->4)-beta-D-mannosyl)(n-1) + alpha-D-mannose 1-phosphate.
          • The enzyme, isolated from the ruminal bacterium Ruminococcus albus, catalyzes the reversible phosphorolysis of beta-1,4- mannooligosaccharide with a minimum size of three monomers.
          		 1 E6UBR9
          Xylan 1,3-beta-xylosidase. [EC: 3.2.1.72]
          Hydrolysis of successive xylose residues from the non-reducing termini of (1->3)-beta-D-xylans.
            		 1 A9ZND1
            Sucrose:sucrose fructosyltransferase. [EC: 2.4.1.99]
            2 sucrose = D-glucose + beta-D-fructofuranosyl-(2->1)-beta-D- fructofuranosyl alpha-D-glucopyranoside.
              		 1 Q9FSV7