View in Gene3D

CATH Superfamily 2.102.10.10

Rieske [2Fe-2S] iron-sulphur domain

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rieske [2Fe-2S] iron-sulphur domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
« Back to all FunFams

FunFam 12: 3-ketosteroid-9-alpha-hydroxylase oxygenase subuni...

There are 1 EC terms in this cluster

Please note: EC annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

Note: The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.

EC Term Annotations Evidence
3-ketosteroid 9-alpha-monooxygenase. [EC: 1.14.15.30]
Androsta-1,4-diene-3,17-dione + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = 9-alpha-hydroxyandrosta-1,4-diene-3,17-dione + 2 oxidized ferredoxin [iron-sulfur] cluster + H(2)O.
  • The enzyme is involved in the cholesterol degradation pathway of several bacterial pathogens, such as Mycobacterium tuberculosis.
  • It forms a two-component system with a ferredoxin reductase (KshB).
  • The enzyme contains a Rieske-type iron-sulfur center and non-heme iron.
  • The product of the enzyme is unstable, and spontaneously converts to 3-hydroxy-9,10-seconandrost-1,3,5(10)-triene-9,17-dione.
  • Formerly EC 1.14.13.142.
 131 A0A045KFG6 A0A045KFG6 A0A045KFG6 A0A045KFG6 A0A045KFG6 A0A045KFG6 A0A045KFG6 A0A045KFG6 A0A045KFG6 A0A045KFG6
(121 more...)