The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Rieske [2Fe-2S] iron-sulphur domain
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 1: Cytochrome b-c1 complex subunit Rieske, mitochondr...

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 12 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Ubiquinol-cytochrome-c reductase activity GO:0008121
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+.
17 Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS)
(7 more)
Glutathione-disulfide reductase activity GO:0004362
Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+.
5 Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM)
Ubiquinol-cytochrome-c reductase activity GO:0008121
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+.
5 Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM)
Metal ion binding GO:0046872
Interacting selectively and non-covalently with any metal ion.
4 Q94JS0 (/IDA) Q94JS0 (/IDA) Q9LYR2 (/IDA) Q9LYR2 (/IDA)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
2 P47985 (/IPI) Q9CR68 (/IPI)
Ubiquinol-cytochrome-c reductase activity GO:0008121
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+.
2 P49727 (/IGI) P49729 (/IGI)
Ubiquinol-cytochrome-c reductase activity GO:0008121
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+.
2 P08067 (/IMP) P08067 (/IMP)
Ubiquinol-cytochrome-c reductase activity GO:0008121
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+.
2 A0A1D8PJX3 (/NAS) A0A1D8PJX3 (/NAS)
2 iron, 2 sulfur cluster binding GO:0051537
Interacting selectively and non-covalently with a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands.
2 P49727 (/RCA) P49729 (/RCA)
Ubiquinol-cytochrome-c reductase activity GO:0008121
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+.
1 P20788 (/TAS)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 P20788 (/IDA)
Protein-containing complex binding GO:0044877
Interacting selectively and non-covalently with a macromolecular complex.
1 Q9CR68 (/ISO)

There are 20 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Oxidation-reduction process GO:0055114
A metabolic process that results in the removal or addition of one or more electrons to or from a substance, with or without the concomitant removal or addition of a proton or protons.
16 Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS)
(6 more)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
5 Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM)
Mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
2 P08067 (/IDA) P08067 (/IDA)
Mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
2 Q54NW9 (/ISS) Q9VQ29 (/ISS)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
2 P49727 (/IGI) P49729 (/IGI)
Aerobic respiration GO:0009060
The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor.
2 P08067 (/IMP) P08067 (/IMP)
Response to heat GO:0009408
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.
2 P49727 (/IGI) P49729 (/IGI)
Negative regulation of protein phosphorylation GO:0001933
Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein.
1 O44512 (/IMP)
Positive regulation of protein phosphorylation GO:0001934
Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein.
1 O44512 (/IMP)
Generation of precursor metabolites and energy GO:0006091
The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances.
1 C8VN54 (/RCA)
Mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
1 Q09154 (/IGI)
Mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
1 O44512 (/IMP)
Mitochondrial electron transport, ubiquinol to cytochrome c GO:0006122
The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III.
1 P47985 (/TAS)
Response to hormone GO:0009725
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.
1 P20788 (/IEP)
Positive regulation of gene expression GO:0010628
Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 O44512 (/IGI)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 O44512 (/IGI)
Negative regulation of gene expression GO:0010629
Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form.
1 O44512 (/IMP)
Response to drug GO:0042493
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease.
1 P20788 (/IEP)
Response to antibiotic GO:0046677
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms.
1 P20788 (/IEP)
Positive regulation of nematode larval development GO:0061063
Any process that increases the rate, frequency, or extent of nematode larval development, the process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew.
1 O44512 (/IGI)

There are 27 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
18 P13272 (/ISS) P13272 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS)
(8 more)
Mitochondrial respiratory chain complex III GO:0005750
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.
18 Q54NW9 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS) Q8IL75 (/ISS)
(8 more)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
14 P47985 (/IDA) P49727 (/IDA) P49729 (/IDA) Q38D40 (/IDA) Q38D40 (/IDA) Q38D40 (/IDA) Q38D40 (/IDA) Q38D40 (/IDA) Q94JS0 (/IDA) Q94JS0 (/IDA)
(4 more)
Mitochondrial respiratory chain complex III GO:0005750
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.
8 P08067 (/IDA) P08067 (/IDA) P20788 (/IDA) P47985 (/IDA) Q94JS0 (/IDA) Q94JS0 (/IDA) Q9LYR2 (/IDA) Q9LYR2 (/IDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
6 P08067 (/HDA) P08067 (/HDA) P47985 (/HDA) Q09154 (/HDA) Q9CR68 (/HDA) Q9VQ29 (/HDA)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
5 Q38D40 (/RCA) Q38D40 (/RCA) Q38D40 (/RCA) Q38D40 (/RCA) Q38D40 (/RCA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
5 Q38D40 (/RCA) Q38D40 (/RCA) Q38D40 (/RCA) Q38D40 (/RCA) Q38D40 (/RCA)
Kinetoplast GO:0020023
A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum.
5 Q38D40 (/IDA) Q38D40 (/IDA) Q38D40 (/IDA) Q38D40 (/IDA) Q38D40 (/IDA)
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
5 P20788 (/IDA) Q94JS0 (/IDA) Q94JS0 (/IDA) Q9LYR2 (/IDA) Q9LYR2 (/IDA)
Respiratory chain complex III GO:0045275
A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species.
5 Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM) Q38D40 (/ISM)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 P08067 (/IPI) P08067 (/IPI)
Mitochondrion GO:0005739
A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
2 E9AEX6 (/ISO) Q9CR68 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
2 P13272 (/ISS) P13272 (/ISS)
Plasma membrane GO:0005886
The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
2 A0A1D8PJX3 (/IDA) A0A1D8PJX3 (/IDA)
Membrane GO:0016020
A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
2 Q94JS0 (/IDA) Q94JS0 (/IDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q9CR68 (/HDA)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 Q09154 (/IGI)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 E9AEX6 (/ISO)
Mitochondrial inner membrane GO:0005743
The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
1 P47985 (/TAS)
Mitochondrial respiratory chain complex III GO:0005750
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.
1 Q09154 (/IGI)
Mitochondrial respiratory chain complex III GO:0005750
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1.
1 Q9CR68 (/ISO)
Mitochondrial respiratory chain complex IV GO:0005751
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
1 P47985 (/IDA)
Mitochondrial respiratory chain complex IV GO:0005751
A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2).
1 Q9CR68 (/ISO)
Mitochondrial membrane GO:0031966
Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope.
1 Q9CR68 (/ISO)
Myelin sheath GO:0043209
An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system.
1 Q9CR68 (/HDA)
Respiratory chain complex III GO:0045275
A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species.
1 P20788 (/TAS)