The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:
"Cystine-knot cytokines
".
FunFam 44: Interleukin 17D
Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.
There are 6 GO terms relating to "molecular function"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
|
3 | A0A0B4J1G4 (/ISO) Q8K4C4 (/ISO) Q8K599 (/ISO) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
3 | A0A0B4J1G4 (/ISO) Q8K4C4 (/ISO) Q8K599 (/ISO) |
|
Receptor ligand activity GO:0048018
The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands).
|
3 | A0A0B4J1G4 (/ISO) Q8K4C4 (/ISO) Q8K599 (/ISO) |
|
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
|
2 | Q8TAD2 (/IDA) Q8TAD2 (/IDA) |
|
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
|
2 | Q8TAD2 (/IDA) Q8TAD2 (/IDA) |
|
Receptor ligand activity GO:0048018
The activity of a gene product that interacts with a receptor to effect a change in the activity of the receptor. Ligands may be produced by the same, or different, cell that expresses the receptor. Ligands may diffuse extracellularly from their point of origin to the receiving cell, or remain attached to an adjacent cell surface (e.g. Notch ligands).
|
2 | Q8TAD2 (/IDA) Q8TAD2 (/IDA) |
There are 13 GO terms relating to "biological process"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
3 | A0A0B4J1G4 (/ISO) Q8K4C4 (/ISO) Q8K599 (/ISO) |
|
Positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725
Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.
|
3 | A0A0B4J1G4 (/ISO) Q8K4C4 (/ISO) Q8K599 (/ISO) |
|
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
|
3 | A0A0B4J1G4 (/ISO) Q8K4C4 (/ISO) Q8K599 (/ISO) |
|
Positive regulation of interleukin-8 production GO:0032757
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
|
3 | A0A0B4J1G4 (/ISO) Q8K4C4 (/ISO) Q8K599 (/ISO) |
|
Positive regulation of cytokine production involved in inflammatory response GO:1900017
Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
|
3 | A0A0B4J1G4 (/ISO) Q8K4C4 (/ISO) Q8K599 (/ISO) |
|
Negative regulation of hemopoiesis GO:1903707
Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.
|
3 | A0A0B4J1G4 (/ISO) Q8K4C4 (/ISO) Q8K599 (/ISO) |
|
Inflammatory response GO:0006954
The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages.
|
2 | Q8TAD2 (/IDA) Q8TAD2 (/IDA) |
|
Positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725
Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.
|
2 | Q8TAD2 (/IDA) Q8TAD2 (/IDA) |
|
Positive regulation of interleukin-6 production GO:0032755
Any process that activates or increases the frequency, rate, or extent of interleukin-6 production.
|
2 | Q8TAD2 (/IDA) Q8TAD2 (/IDA) |
|
Positive regulation of interleukin-8 production GO:0032757
Any process that activates or increases the frequency, rate, or extent of interleukin-8 production.
|
2 | Q8TAD2 (/IDA) Q8TAD2 (/IDA) |
|
Positive regulation of cytokine production involved in inflammatory response GO:1900017
Any process that activates or increases the frequency, rate or extent of cytokine production involved in inflammatory response.
|
2 | Q8TAD2 (/IDA) Q8TAD2 (/IDA) |
|
Negative regulation of hemopoiesis GO:1903707
Any process that stops, prevents or reduces the frequency, rate or extent of hemopoiesis.
|
2 | Q8TAD2 (/IDA) Q8TAD2 (/IDA) |
|
Cellular response to lipopolysaccharide GO:0071222
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
|
1 | Q5TKT1 (/IDA) |
There are 2 GO terms relating to "cellular component"
The search results have been sorted with the annotations that are found most frequently at the top of the
list. The results can be filtered by typing text into the search box at the top of the table.
| GO Term | Annotations | Evidence |
|---|---|---|
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
3 | A0A0B4J1G4 (/ISO) Q8K4C4 (/ISO) Q8K599 (/ISO) |
|
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
|
2 | Q8TAD2 (/IDA) Q8TAD2 (/IDA) |