The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
Cystine-knot cytokines
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.
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FunFam 22: Norrin

Please note: GO annotations are assigned to the full protein sequence rather than individual protein domains. Since a given protein can contain multiple domains, it is possible that some of the annotations below come from additional domains that occur in the same protein, but have been classified elsewhere in CATH.

There are 7 GO terms relating to "molecular function"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
18 P48744 (/IPI) P48744 (/IPI) P48744 (/IPI) P48744 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI)
(8 more)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
18 P48744 (/IDA) P48744 (/IDA) P48744 (/IDA) P48744 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA)
(8 more)
Protein binding GO:0005515
Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules).
14 Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI)
(4 more)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
14 Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI) Q00604 (/IPI)
(4 more)
Frizzled binding GO:0005109
Interacting selectively and non-covalently with a frizzled (fz) receptor.
4 P48744 (/ISO) P48744 (/ISO) P48744 (/ISO) P48744 (/ISO)
Cytokine activity GO:0005125
Functions to control the survival, growth, differentiation and effector function of tissues and cells.
4 P48744 (/ISO) P48744 (/ISO) P48744 (/ISO) P48744 (/ISO)
Protein homodimerization activity GO:0042803
Interacting selectively and non-covalently with an identical protein to form a homodimer.
4 P48744 (/ISO) P48744 (/ISO) P48744 (/ISO) P48744 (/ISO)

There are 14 GO terms relating to "biological process"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
18 P48744 (/IDA) P48744 (/IDA) P48744 (/IDA) P48744 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA)
(8 more)
Norrin signaling pathway GO:0110135
The series of molecular signals initiated by binding of the cysteine knot protein Norrin to a Frizzled 4 (Fzd4) family receptor on the surface of the target cell and ending with a change in cell state.
18 P48744 (/IDA) P48744 (/IDA) P48744 (/IDA) P48744 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA)
(8 more)
Vacuole organization GO:0007033
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole.
14 Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS)
(4 more)
Nervous system development GO:0007399
The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
14 Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS)
(4 more)
Visual perception GO:0007601
The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image.
14 Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS) Q00604 (/TAS)
(4 more)
Placenta development GO:0001890
The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin.
4 P48744 (/IMP) P48744 (/IMP) P48744 (/IMP) P48744 (/IMP)
Extracellular matrix-cell signaling GO:0035426
Any process that mediates the transfer of information between the extracellular matrix and a cell.
4 P48744 (/IDA) P48744 (/IDA) P48744 (/IDA) P48744 (/IDA)
Positive regulation of transcription, DNA-templated GO:0045893
Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription.
4 P48744 (/ISO) P48744 (/ISO) P48744 (/ISO) P48744 (/ISO)
Decidualization GO:0046697
The cellular and vascular changes occurring in the endometrium of the pregnant uterus just after the onset of blastocyst implantation. This process involves the proliferation and differentiation of the fibroblast-like endometrial stromal cells into large, polyploid decidual cells that eventually form the maternal component of the placenta.
4 D3ZEP2 (/IEP) D3ZEP2 (/IEP) D3ZEP2 (/IEP) D3ZEP2 (/IEP)
Positive regulation of DNA-binding transcription factor activity GO:0051091
Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription.
4 P48744 (/IDA) P48744 (/IDA) P48744 (/IDA) P48744 (/IDA)
Retina vasculature morphogenesis in camera-type eye GO:0061299
The process in which the vasculature of the retina is generated and organized.
4 P48744 (/IGI) P48744 (/IGI) P48744 (/IGI) P48744 (/IGI)
Norrin signaling pathway GO:0110135
The series of molecular signals initiated by binding of the cysteine knot protein Norrin to a Frizzled 4 (Fzd4) family receptor on the surface of the target cell and ending with a change in cell state.
4 P48744 (/ISO) P48744 (/ISO) P48744 (/ISO) P48744 (/ISO)
Retina vasculature development in camera-type eye GO:0061298
The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.
1 E7F073 (/IGI)
Retina vasculature development in camera-type eye GO:0061298
The process whose specific outcome is the progression of the vasculature of the retina over time, from its formation to the mature structure.
1 E7F073 (/IMP)

There are 6 GO terms relating to "cellular component"

The search results have been sorted with the annotations that are found most frequently at the top of the list. The results can be filtered by typing text into the search box at the top of the table.
GO Term Annotations Evidence
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
18 P48744 (/IDA) P48744 (/IDA) P48744 (/IDA) P48744 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA)
(8 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
14 Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA)
(4 more)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
14 Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA) Q00604 (/IDA)
(4 more)
Extracellular space GO:0005615
That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
4 P48744 (/ISO) P48744 (/ISO) P48744 (/ISO) P48744 (/ISO)
Cell surface GO:0009986
The external part of the cell wall and/or plasma membrane.
4 P48744 (/ISO) P48744 (/ISO) P48744 (/ISO) P48744 (/ISO)
Collagen-containing extracellular matrix GO:0062023
An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells.
4 P48744 (/ISO) P48744 (/ISO) P48744 (/ISO) P48744 (/ISO)